BRD-K37687095_AZD-8330_A549_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

241 genes differentially expressed following the BRD-K37687095_AZD-8330_A549_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABAT 4-aminobutyrate aminotransferase
ABLIM1 actin binding LIM protein 1
ACKR3 atypical chemokine receptor 3
AHCYL2 adenosylhomocysteinase-like 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP9A ATPase, class II, type 9A
BCL3 B-cell CLL/lymphoma 3
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CA12 carbonic anhydrase XII
CFB complement factor B
CFD complement factor D (adipsin)
COL1A1 collagen, type I, alpha 1
COL5A1 collagen, type V, alpha 1
CRIP1 cysteine-rich protein 1 (intestinal)
CRYAB crystallin, alpha B
CTTN cortactin
CX3CL1 chemokine (C-X3-C motif) ligand 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDAH2 dimethylarginine dimethylaminohydrolase 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
EFHD1 EF-hand domain family, member D1
EFNA1 ephrin-A1
EGFL6 EGF-like-domain, multiple 6
F11R F11 receptor
FAM134B family with sequence similarity 134, member B
FOLR1 folate receptor 1 (adult)
FOXO1 forkhead box O1
FOXO4 forkhead box O4
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLUL glutamate-ammonia ligase
GSN gelsolin
HLA-B major histocompatibility complex, class I, B
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
IL32 interleukin 32
IRF6 interferon regulatory factor 6
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KIFAP3 kinesin-associated protein 3
KLF6 Kruppel-like factor 6
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LAMA3 laminin, alpha 3
LOX lysyl oxidase
LTBP1 latent transforming growth factor beta binding protein 1
LTBP2 latent transforming growth factor beta binding protein 2
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP7 microtubule-associated protein 7
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MATN2 matrilin 2
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MT1M metallothionein 1M
MT1X metallothionein 1X
MYLK myosin light chain kinase
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NDRG1 N-myc downstream regulated 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NREP neuronal regeneration related protein
OSR2 odd-skipped related transciption factor 2
PALLD palladin, cytoskeletal associated protein
PCSK5 proprotein convertase subtilisin/kexin type 5
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFD platelet derived growth factor D
PHYH phytanoyl-CoA 2-hydroxylase
PIEZO2 piezo-type mechanosensitive ion channel component 2
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
POSTN periostin, osteoblast specific factor
PSD3 pleckstrin and Sec7 domain containing 3
PXDN peroxidasin
PYCARD PYD and CARD domain containing
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB40B RAB40B, member RAS oncogene family
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RCAN1 regulator of calcineurin 1
RUNX1 runt-related transcription factor 1
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFXN3 sideroflexin 3
SIK1 salt-inducible kinase 1
SNAI2 snail family zinc finger 2
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPON2 spondin 2, extracellular matrix protein
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SYBU syntabulin (syntaxin-interacting)
SYNGR3 synaptogyrin 3
SYNM synemin, intermediate filament protein
SYNPO synaptopodin
TAGLN2 transgelin 2
TBXA2R thromboxane A2 receptor
TPM2 tropomyosin 2 (beta)
TRIM29 tripartite motif containing 29
TSKU tsukushi, small leucine rich proteoglycan
TTC3 tetratricopeptide repeat domain 3
TTC39A tetratricopeptide repeat domain 39A
TXNIP thioredoxin interacting protein
VAMP8 vesicle-associated membrane protein 8
VAT1 vesicle amine transport 1
VAV3 vav 3 guanine nucleotide exchange factor
VTCN1 V-set domain containing T cell activation inhibitor 1
WDTC1 WD and tetratricopeptide repeats 1
WFDC1 WAP four-disulfide core domain 1
YPEL5 yippee-like 5 (Drosophila)
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA1 annexin A1
ARHGAP29 Rho GTPase activating protein 29
ASRGL1 asparaginase like 1
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
C7 complement component 7
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCND1 cyclin D1
CD1E CD1e molecule
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK1 cyclin-dependent kinase 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CENPA centromere protein A
CRISP3 cysteine-rich secretory protein 3
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ECT2 epithelial cell transforming 2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
EREG epiregulin
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ETV1 ets variant 1
ETV5 ets variant 5
EXO1 exonuclease 1
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FEN1 flap structure-specific endonuclease 1
FGF13 fibroblast growth factor 13
FGL2 fibrinogen-like 2
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GDF15 growth differentiation factor 15
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GSAP gamma-secretase activating protein
H2AFX H2A histone family, member X
HJURP Holliday junction recognition protein
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IER5 immediate early response 5
IGFBP4 insulin-like growth factor binding protein 4
KIF18B kinesin family member 18B
KLK11 kallikrein-related peptidase 11
LDB2 LIM domain binding 2
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MLPH melanophilin
MMP9 matrix metallopeptidase 9
MRPS2 mitochondrial ribosomal protein S2
NAV3 neuron navigator 3
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NPTX1 neuronal pentraxin I
NRGN neurogranin (protein kinase C substrate, RC3)
NRN1 neuritin 1
NT5E 5'-nucleotidase, ecto (CD73)
NTS neurotensin
ODC1 ornithine decarboxylase 1
PAEP progestagen-associated endometrial protein
PFKM phosphofructokinase, muscle
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RAD51C RAD51 paralog C
RAP1GAP RAP1 GTPase activating protein
RFC3 replication factor C (activator 1) 3, 38kDa
RGS2 regulator of G-protein signaling 2
RHOBTB3 Rho-related BTB domain containing 3
RPIA ribose 5-phosphate isomerase A
RRM2 ribonucleotide reductase M2
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae)
SPC25 SPC25, NDC80 kinetochore complex component
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRM spermidine synthase
SRSF7 serine/arginine-rich splicing factor 7
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX1A syntaxin 1A (brain)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCF4 transcription factor 4
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TROAP trophinin associated protein
TSPAN4 tetraspanin 4
TSPAN5 tetraspanin 5
TSPAN8 tetraspanin 8
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein