BRD-K37687095_AZD-8330_A375_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

356 genes differentially expressed following the BRD-K37687095_AZD-8330_A375_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
AHNAK2 AHNAK nucleoprotein 2
ANXA4 annexin A4
AQP1 aquaporin 1 (Colton blood group)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BBS1 Bardet-Biedl syndrome 1
BCAM basal cell adhesion molecule (Lutheran blood group)
BEX4 brain expressed, X-linked 4
BST2 bone marrow stromal cell antigen 2
BTG2 BTG family, member 2
C14ORF159 chromosome 14 open reading frame 159
C1R complement component 1, r subcomponent
C1RL complement component 1, r subcomponent-like
C1S complement component 1, s subcomponent
C3 complement component 3
C9ORF3 chromosome 9 open reading frame 3
CAPN1 calpain 1, (mu/I) large subunit
CCPG1 cell cycle progression 1
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CEP70 centrosomal protein 70kDa
CES2 carboxylesterase 2
CFB complement factor B
CFD complement factor D (adipsin)
CFLAR CASP8 and FADD-like apoptosis regulator
CLCA4 chloride channel accessory 4
COL11A1 collagen, type XI, alpha 1
COL9A2 collagen, type IX, alpha 2
CPB1 carboxypeptidase B1 (tissue)
CRABP2 cellular retinoic acid binding protein 2
CRYAB crystallin, alpha B
CTSA cathepsin A
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
DDR1 discoidin domain receptor tyrosine kinase 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DHRS3 dehydrogenase/reductase (SDR family) member 3
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EFNA1 ephrin-A1
EFS embryonal Fyn-associated substrate
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB4 erb-b2 receptor tyrosine kinase 4
F11R F11 receptor
FAM134B family with sequence similarity 134, member B
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOSL2 FOS-like antigen 2
FTH1 ferritin, heavy polypeptide 1
FXYD3 FXYD domain containing ion transport regulator 3
GBP2 guanylate binding protein 2, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
GMPR guanosine monophosphate reductase
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GPRC5B G protein-coupled receptor, class C, group 5, member B
GSDMB gasdermin B
GSN gelsolin
GSTA1 glutathione S-transferase alpha 1
GSTA4 glutathione S-transferase alpha 4
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HILPDA hypoxia inducible lipid droplet-associated
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-E major histocompatibility complex, class I, E
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HOOK2 hook microtubule-tethering protein 2
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
IRF9 interferon regulatory factor 9
ISYNA1 inositol-3-phosphate synthase 1
ITM2B integral membrane protein 2B
JUN jun proto-oncogene
JUP junction plakoglobin
LAMP2 lysosomal-associated membrane protein 2
LIMK2 LIM domain kinase 2
LMOD1 leiomodin 1 (smooth muscle)
LPAR6 lysophosphatidic acid receptor 6
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGED2 melanoma antigen family D2
MAN1A1 mannosidase, alpha, class 1A, member 1
MATN2 matrilin 2
MDK midkine (neurite growth-promoting factor 2)
MECOM MDS1 and EVI1 complex locus
MEF2C myocyte enhancer factor 2C
METTL7A methyltransferase like 7A
MN1 meningioma (disrupted in balanced translocation) 1
MTMR11 myotubularin related protein 11
MTSS1 metastasis suppressor 1
MUC1 mucin 1, cell surface associated
MVP major vault protein
MXRA5 matrix-remodelling associated 5
MYLK myosin light chain kinase
NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
NEFH neurofilament, heavy polypeptide
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NMU neuromedin U
NOV nephroblastoma overexpressed
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
OPLAH 5-oxoprolinase (ATP-hydrolysing)
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
OSR2 odd-skipped related transciption factor 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFD platelet derived growth factor D
PEG3 paternally expressed 3
PGAP3 post-GPI attachment to proteins 3
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PIR pirin (iron-binding nuclear protein)
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRAME preferentially expressed antigen in melanoma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
PYCARD PYD and CARD domain containing
QPRT quinolinate phosphoribosyltransferase
RABGAP1L RAB GTPase activating protein 1-like
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
ROGDI rogdi homolog (Drosophila)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCRG1 stimulator of chondrogenesis 1
SERINC5 serine incorporator 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC35E3 solute carrier family 35, member E3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SOD2 superoxide dismutase 2, mitochondrial
SOX2 SRY (sex determining region Y)-box 2
SPATA20 spermatogenesis associated 20
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPON2 spondin 2, extracellular matrix protein
SPTSSA serine palmitoyltransferase, small subunit A
SSPN sarcospan
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYNPO synaptopodin
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TM7SF2 transmembrane 7 superfamily member 2
TMEM35 transmembrane protein 35
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX3 TOX high mobility group box family member 3
TP53I3 tumor protein p53 inducible protein 3
TP63 tumor protein p63
TPP1 tripeptidyl peptidase I
TPPP3 tubulin polymerization-promoting protein family member 3
TRIM2 tripartite motif containing 2
TRIM22 tripartite motif containing 22
TSPAN31 tetraspanin 31
TUBB2B tubulin, beta 2B class IIb
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAV3 vav 3 guanine nucleotide exchange factor
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC1 WAP four-disulfide core domain 1
WFDC2 WAP four-disulfide core domain 2
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
AMD1 adenosylmethionine decarboxylase 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA3 annexin A3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BOP1 block of proliferation 1
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCND1 cyclin D1
CD24 CD24 molecule
CD3EAP CD3e molecule, epsilon associated protein
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CIT citron rho-interacting serine/threonine kinase
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
COL4A2 collagen, type IV, alpha 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CST1 cystatin SN
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DBF4 DBF4 zinc finger
DCBLD2 discoidin, CUB and LCCL domain containing 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ECT2 epithelial cell transforming 2
EFHD2 EF-hand domain family, member D2
EIF4E eukaryotic translation initiation factor 4E
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO1 enolase 1, (alpha)
EPHA2 EPH receptor A2
ETV1 ets variant 1
ETV4 ets variant 4
ETV5 ets variant 5
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCI Fanconi anemia, complementation group I
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GDF15 growth differentiation factor 15
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSPT1 G1 to S phase transition 1
GTPBP4 GTP binding protein 4
GTSE1 G-2 and S-phase expressed 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
H2AFZ H2A histone family, member Z
HES1 hes family bHLH transcription factor 1
HJURP Holliday junction recognition protein
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HMGB2 high mobility group box 2
HSPA8 heat shock 70kDa protein 8
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
ITGB5 integrin, beta 5
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF23 kinesin family member 23
KRT18 keratin 18, type I
LIF leukemia inhibitory factor
LIG1 ligase I, DNA, ATP-dependent
LMNB2 lamin B2
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MALL mal, T-cell differentiation protein-like
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYO10 myosin X
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NET1 neuroepithelial cell transforming 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFIB nuclear factor I/B
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PDLIM5 PDZ and LIM domain 5
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNP purine nucleoside phosphorylase
PRC1 protein regulator of cytokinesis 1
RACGAP1 Rac GTPase activating protein 1
RAD51 RAD51 recombinase
RAD51C RAD51 paralog C
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFWD3 ring finger and WD repeat domain 3
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SFN stratifin
SFRP1 secreted frizzled-related protein 1
SHCBP1 SHC SH2-domain binding protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC43A3 solute carrier family 43, member 3
SMC4 structural maintenance of chromosomes 4
SPATS2L spermatogenesis associated, serine-rich 2-like
SPC25 SPC25, NDC80 kinetochore complex component
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRM spermidine synthase
SRSF2 serine/arginine-rich splicing factor 2
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
STK17A serine/threonine kinase 17a
STX1A syntaxin 1A (brain)
TACC3 transforming, acidic coiled-coil containing protein 3
TCL1A T-cell leukemia/lymphoma 1A
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TMPO thymopoietin
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRA2B transformer 2 beta homolog (Drosophila)
TRIP13 thyroid hormone receptor interactor 13
TTK TTK protein kinase
TYMS thymidylate synthetase
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UPP1 uridine phosphorylase 1
VRK1 vaccinia related kinase 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZWINT ZW10 interacting kinetochore protein