BRD-K37687095_AZD-8330_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

329 genes differentially expressed following the BRD-K37687095_AZD-8330_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABHD4 abhydrolase domain containing 4
ABLIM1 actin binding LIM protein 1
ACKR3 atypical chemokine receptor 3
ACTG2 actin, gamma 2, smooth muscle, enteric
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
AHNAK2 AHNAK nucleoprotein 2
ANGPT1 angiopoietin 1
ANXA4 annexin A4
AQP1 aquaporin 1 (Colton blood group)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BEX1 brain expressed, X-linked 1
BEX4 brain expressed, X-linked 4
BTG1 B-cell translocation gene 1, anti-proliferative
C1R complement component 1, r subcomponent
C1RL complement component 1, r subcomponent-like
C1S complement component 1, s subcomponent
CAPN1 calpain 1, (mu/I) large subunit
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFB complement factor B
CFD complement factor D (adipsin)
CLU clusterin
COL11A1 collagen, type XI, alpha 1
COL14A1 collagen, type XIV, alpha 1
COL18A1 collagen, type XVIII, alpha 1
COL1A2 collagen, type I, alpha 2
COL21A1 collagen, type XXI, alpha 1
CPQ carboxypeptidase Q
CRABP2 cellular retinoic acid binding protein 2
CRYAB crystallin, alpha B
CTSA cathepsin A
CXCL12 chemokine (C-X-C motif) ligand 12
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCN decorin
DDR1 discoidin domain receptor tyrosine kinase 1
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DEPTOR DEP domain containing MTOR-interacting protein
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EFNA1 ephrin-A1
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM134B family with sequence similarity 134, member B
FAM63A family with sequence similarity 63, member A
FBLN2 fibulin 2
FCGBP Fc fragment of IgG binding protein
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FXYD3 FXYD domain containing ion transport regulator 3
GJA1 gap junction protein, alpha 1, 43kDa
GOLGA8H golgin A8 family, member H
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GSDMB gasdermin B
GSN gelsolin
GSTA1 glutathione S-transferase alpha 1
GSTA4 glutathione S-transferase alpha 4
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HOOK2 hook microtubule-tethering protein 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA2 heat shock 70kDa protein 2
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
JUN jun proto-oncogene
JUP junction plakoglobin
KIZ kizuna centrosomal protein
KLHL24 kelch-like family member 24
KRT19 keratin 19, type I
LAGE3 L antigen family, member 3
LIMK2 LIM domain kinase 2
LMBRD1 LMBR1 domain containing 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGED2 melanoma antigen family D2
MATN2 matrilin 2
MEF2C myocyte enhancer factor 2C
MN1 meningioma (disrupted in balanced translocation) 1
MTSS1 metastasis suppressor 1
MUC1 mucin 1, cell surface associated
MVP major vault protein
MYL9 myosin, light chain 9, regulatory
MYLK myosin light chain kinase
NDRG1 N-myc downstream regulated 1
NEFH neurofilament, heavy polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NMRK1 nicotinamide riboside kinase 1
NOV nephroblastoma overexpressed
NRCAM neuronal cell adhesion molecule
NSG1 neuron specific gene family member 1
NUPR1 nuclear protein, transcriptional regulator, 1
OBSL1 obscurin-like 1
ORAI3 ORAI calcium release-activated calcium modulator 3
OSBPL9 oxysterol binding protein-like 9
OSR2 odd-skipped related transciption factor 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFD platelet derived growth factor D
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIR pirin (iron-binding nuclear protein)
PLP1 proteolipid protein 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPAP2A phosphatidic acid phosphatase type 2A
PROS1 protein S (alpha)
PRUNE2 prune homolog 2 (Drosophila)
PTN pleiotrophin
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PYCARD PYD and CARD domain containing
RABAC1 Rab acceptor 1 (prenylated)
RABGAP1L RAB GTPase activating protein 1-like
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBKS ribokinase
RBP1 retinol binding protein 1, cellular
REEP1 receptor accessory protein 1
RGS1 regulator of G-protein signaling 1
RHOQ ras homolog family member Q
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCRG1 stimulator of chondrogenesis 1
SECISBP2L SECIS binding protein 2-like
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC22A18 solute carrier family 22, member 18
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOX2 SRY (sex determining region Y)-box 2
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
SPON2 spondin 2, extracellular matrix protein
SSPN sarcospan
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STK38 serine/threonine kinase 38
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SYNE2 spectrin repeat containing, nuclear envelope 2
SYNPO synaptopodin
TAGLN transgelin
TOX thymocyte selection-associated high mobility group box
TP53I3 tumor protein p53 inducible protein 3
TP53TG1 TP53 target 1 (non-protein coding)
TRDV3 T cell receptor delta variable 3
TRIM2 tripartite motif containing 2
TRIM22 tripartite motif containing 22
TSPAN31 tetraspanin 31
TTC39A tetratricopeptide repeat domain 39A
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAV3 vav 3 guanine nucleotide exchange factor
VCAN versican
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC1 WAP four-disulfide core domain 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
ACTN1 actinin, alpha 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMD1 adenosylmethionine decarboxylase 1
ANO1 anoctamin 1, calcium activated chloride channel
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA3 annexin A3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AREG amphiregulin
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BOP1 block of proliferation 1
BRCA1 breast cancer 1, early onset
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CCND1 cyclin D1
CD24 CD24 molecule
CD3EAP CD3e molecule, epsilon associated protein
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CEP55 centrosomal protein 55kDa
CIT citron rho-interacting serine/threonine kinase
CKS1B CDC28 protein kinase regulatory subunit 1B
COL4A2 collagen, type IV, alpha 2
COL6A1 collagen, type VI, alpha 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DBF4 DBF4 zinc finger
DCBLD2 discoidin, CUB and LCCL domain containing 2
DEPDC1 DEP domain containing 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ECT2 epithelial cell transforming 2
EFHD2 EF-hand domain family, member D2
EIF4E eukaryotic translation initiation factor 4E
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO1 enolase 1, (alpha)
EPHA2 EPH receptor A2
EREG epiregulin
ETV1 ets variant 1
ETV4 ets variant 4
ETV5 ets variant 5
EXO1 exonuclease 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FBP1 fructose-1,6-bisphosphatase 1
FEN1 flap structure-specific endonuclease 1
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GAL galanin/GMAP prepropeptide
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GTSE1 G-2 and S-phase expressed 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HJURP Holliday junction recognition protein
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HMGB2 high mobility group box 2
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
IL13RA2 interleukin 13 receptor, alpha 2
ITGB5 integrin, beta 5
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KRT18 keratin 18, type I
KRT7 keratin 7, type II
LIF leukemia inhibitory factor
LMNB2 lamin B2
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM7 minichromosome maintenance complex component 7
MGLL monoglyceride lipase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MICB MHC class I polypeptide-related sequence B
MKI67 marker of proliferation Ki-67
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYO10 myosin X
NCAPG non-SMC condensin I complex, subunit G
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NET1 neuroepithelial cell transforming 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP56 NOP56 ribonucleoprotein
NRGN neurogranin (protein kinase C substrate, RC3)
NT5E 5'-nucleotidase, ecto (CD73)
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PFKP phosphofructokinase, platelet
PGC progastricsin (pepsinogen C)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
PLEK2 pleckstrin 2
PLK1 polo-like kinase 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNP purine nucleoside phosphorylase
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPAT phosphoribosyl pyrophosphate amidotransferase
RACGAP1 Rac GTPase activating protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RGS4 regulator of G-protein signaling 4
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SFRP1 secreted frizzled-related protein 1
SHCBP1 SHC SH2-domain binding protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMAGP small cell adhesion glycoprotein
SMC4 structural maintenance of chromosomes 4
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRM spermidine synthase
SRSF7 serine/arginine-rich splicing factor 7
STC1 stanniocalcin 1
STX1A syntaxin 1A (brain)
TACC3 transforming, acidic coiled-coil containing protein 3
TCL1A T-cell leukemia/lymphoma 1A
TGM2 transglutaminase 2
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM2 transmembrane protein 2
TMPO thymopoietin
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UCK2 uridine-cytidine kinase 2
UPP1 uridine phosphorylase 1
WSB2 WD repeat and SOCS box containing 2
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein