BRD-K37687095_AZD-8330_A375_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

361 genes differentially expressed following the BRD-K37687095_AZD-8330_A375_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABAT 4-aminobutyrate aminotransferase
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABLIM1 actin binding LIM protein 1
ACKR3 atypical chemokine receptor 3
ACTG2 actin, gamma 2, smooth muscle, enteric
ADIRF adipogenesis regulatory factor
AHNAK2 AHNAK nucleoprotein 2
ANGPT1 angiopoietin 1
ANKRD6 ankyrin repeat domain 6
ANXA4 annexin A4
AQP1 aquaporin 1 (Colton blood group)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARMCX2 armadillo repeat containing, X-linked 2
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
ATRAID all-trans retinoic acid-induced differentiation factor
AUH AU RNA binding protein/enoyl-CoA hydratase
BEX4 brain expressed, X-linked 4
BST2 bone marrow stromal cell antigen 2
BTG2 BTG family, member 2
C1R complement component 1, r subcomponent
C1RL complement component 1, r subcomponent-like
C3 complement component 3
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAV2 caveolin 2
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC92 coiled-coil domain containing 92
CCND2 cyclin D2
CD200 CD200 molecule
CFB complement factor B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
CPQ carboxypeptidase Q
CRYAB crystallin, alpha B
CX3CR1 chemokine (C-X3-C motif) receptor 1
DCN decorin
DDR1 discoidin domain receptor tyrosine kinase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DHRS1 dehydrogenase/reductase (SDR family) member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EFNA1 ephrin-A1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
F11R F11 receptor
F13A1 coagulation factor XIII, A1 polypeptide
FAM63A family with sequence similarity 63, member A
FCGBP Fc fragment of IgG binding protein
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FILIP1L filamin A interacting protein 1-like
FKBP1B FK506 binding protein 1B, 12.6 kDa
GAS1 growth arrest-specific 1
GATA6 GATA binding protein 6
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GOLGA8H golgin A8 family, member H
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GPRC5B G protein-coupled receptor, class C, group 5, member B
GSDMB gasdermin B
GSN gelsolin
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-E major histocompatibility complex, class I, E
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP5 insulin-like growth factor binding protein 5
IRF9 interferon regulatory factor 9
ISYNA1 inositol-3-phosphate synthase 1
ITM2B integral membrane protein 2B
JUN jun proto-oncogene
KDM5D lysine (K)-specific demethylase 5D
KLHL24 kelch-like family member 24
LAMP2 lysosomal-associated membrane protein 2
LIMK2 LIM domain kinase 2
LMBRD1 LMBR1 domain containing 1
LMOD1 leiomodin 1 (smooth muscle)
LOX lysyl oxidase
LUM lumican
LXN latexin
LY96 lymphocyte antigen 96
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGED2 melanoma antigen family D2
MAOA monoamine oxidase A
MATN2 matrilin 2
MEF2C myocyte enhancer factor 2C
MEIS2 Meis homeobox 2
METRN meteorin, glial cell differentiation regulator
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MN1 meningioma (disrupted in balanced translocation) 1
MTSS1 metastasis suppressor 1
MVP major vault protein
MXRA5 matrix-remodelling associated 5
MYL9 myosin, light chain 9, regulatory
MYLK myosin light chain kinase
NCAM1 neural cell adhesion molecule 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOV nephroblastoma overexpressed
NRCAM neuronal cell adhesion molecule
NSG1 neuron specific gene family member 1
NUPR1 nuclear protein, transcriptional regulator, 1
OBSL1 obscurin-like 1
OGN osteoglycin
OLFML2A olfactomedin-like 2A
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
OSBPL9 oxysterol binding protein-like 9
OSR2 odd-skipped related transciption factor 2
OXTR oxytocin receptor
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCP4 Purkinje cell protein 4
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFD platelet derived growth factor D
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLEKHA5 pleckstrin homology domain containing, family A member 5
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLI polymerase (DNA directed) iota
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGIS prostaglandin I2 (prostacyclin) synthase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
PYCARD PYD and CARD domain containing
QPCT glutaminyl-peptide cyclotransferase
RABAC1 Rab acceptor 1 (prenylated)
RABGAP1L RAB GTPase activating protein 1-like
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS1 regulator of G-protein signaling 1
RHOQ ras homolog family member Q
RTN2 reticulon 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCRG1 stimulator of chondrogenesis 1
SELENBP1 selenium binding protein 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC22A18 solute carrier family 22, member 18
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SNAI2 snail family zinc finger 2
SOD2 superoxide dismutase 2, mitochondrial
SOX2 SRY (sex determining region Y)-box 2
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
SPON2 spondin 2, extracellular matrix protein
SPTSSA serine palmitoyltransferase, small subunit A
SSPN sarcospan
ST5 suppression of tumorigenicity 5
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STON1 stonin 1
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SYNE2 spectrin repeat containing, nuclear envelope 2
TAGLN transgelin
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS2 thrombospondin 2
TLE4 transducin-like enhancer of split 4
TM7SF2 transmembrane 7 superfamily member 2
TMOD1 tropomodulin 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX thymocyte selection-associated high mobility group box
TP63 tumor protein p63
TPD52L1 tumor protein D52-like 1
TPM2 tropomyosin 2 (beta)
TPP1 tripeptidyl peptidase I
TRIM2 tripartite motif containing 2
TRIM22 tripartite motif containing 22
TRPS1 trichorhinophalangeal syndrome I
TSPAN31 tetraspanin 31
TTC39A tetratricopeptide repeat domain 39A
TYROBP TYRO protein tyrosine kinase binding protein
UBXN4 UBX domain protein 4
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAV3 vav 3 guanine nucleotide exchange factor
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
VTCN1 V-set domain containing T cell activation inhibitor 1
VWA5A von Willebrand factor A domain containing 5A
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMD1 adenosylmethionine decarboxylase 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA3 annexin A3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BOP1 block of proliferation 1
BRCA1 breast cancer 1, early onset
CCDC86 coiled-coil domain containing 86
CCNA2 cyclin A2
CCND1 cyclin D1
CD24 CD24 molecule
CD3EAP CD3e molecule, epsilon associated protein
CDC20 cell division cycle 20
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPN centromere protein N
CEP55 centrosomal protein 55kDa
CIT citron rho-interacting serine/threonine kinase
COL4A2 collagen, type IV, alpha 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CST1 cystatin SN
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DBF4 DBF4 zinc finger
DCBLD2 discoidin, CUB and LCCL domain containing 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNMBP dynamin binding protein
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
ECT2 epithelial cell transforming 2
EFHD2 EF-hand domain family, member D2
EIF4E eukaryotic translation initiation factor 4E
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO1 enolase 1, (alpha)
EPHA2 EPH receptor A2
EREG epiregulin
ETV1 ets variant 1
ETV4 ets variant 4
ETV5 ets variant 5
EXO1 exonuclease 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FEN1 flap structure-specific endonuclease 1
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GDF15 growth differentiation factor 15
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GTSE1 G-2 and S-phase expressed 1
HES1 hes family bHLH transcription factor 1
HJURP Holliday junction recognition protein
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HMGB2 high mobility group box 2
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
ITGB5 integrin, beta 5
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
LIF leukemia inhibitory factor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LMNB2 lamin B2
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM7 minichromosome maintenance complex component 7
MCUR1 mitochondrial calcium uniporter regulator 1
MGLL monoglyceride lipase
MKI67 marker of proliferation Ki-67
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYO10 myosin X
NCAPG non-SMC condensin I complex, subunit G
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NET1 neuroepithelial cell transforming 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NOP56 NOP56 ribonucleoprotein
NRGN neurogranin (protein kinase C substrate, RC3)
NT5E 5'-nucleotidase, ecto (CD73)
PA2G4 proliferation-associated 2G4, 38kDa
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PFKP phosphofructokinase, platelet
PGC progastricsin (pepsinogen C)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPARG peroxisome proliferator-activated receptor gamma
PPAT phosphoribosyl pyrophosphate amidotransferase
RACGAP1 Rac GTPase activating protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A9 S100 calcium binding protein A9
SEH1L SEH1-like (S. cerevisiae)
SFN stratifin
SHCBP1 SHC SH2-domain binding protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC43A3 solute carrier family 43, member 3
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMAGP small cell adhesion glycoprotein
SMC4 structural maintenance of chromosomes 4
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SPC25 SPC25, NDC80 kinetochore complex component
SPRR3 small proline-rich protein 3
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRM spermidine synthase
SRSF7 serine/arginine-rich splicing factor 7
STX1A syntaxin 1A (brain)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TCL1A T-cell leukemia/lymphoma 1A
TIPIN TIMELESS interacting protein
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TMPO thymopoietin
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TSPAN8 tetraspanin 8
TUBB tubulin, beta class I
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UCK2 uridine-cytidine kinase 2
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein