BRD-K37687095_AZD-8330_A375_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

103 genes differentially expressed following the BRD-K37687095_AZD-8330_A375_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
AKR1C3 aldo-keto reductase family 1, member C3
AMPH amphiphysin
ANXA4 annexin A4
ASS1 argininosuccinate synthase 1
BST2 bone marrow stromal cell antigen 2
C1R complement component 1, r subcomponent
C1RL complement component 1, r subcomponent-like
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCNF cyclin F
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFB complement factor B
CHN1 chimerin 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
DARS aspartyl-tRNA synthetase
DENND2D DENN/MADD domain containing 2D
EDN1 endothelin 1
EVI2A ecotropic viral integration site 2A
GPNMB glycoprotein (transmembrane) nmb
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HNMT histamine N-methyltransferase
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFITM1 interferon induced transmembrane protein 1
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
LY6E lymphocyte antigen 6 complex, locus E
LYPD1 LY6/PLAUR domain containing 1
MDK midkine (neurite growth-promoting factor 2)
MSLN mesothelin
MX2 MX dynamin-like GTPase 2
NMU neuromedin U
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PDGFC platelet derived growth factor C
PF4 platelet factor 4
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PRUNE2 prune homolog 2 (Drosophila)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTN pleiotrophin
RSAD2 radical S-adenosyl methionine domain containing 2
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SNN stannin
SOX2 SRY (sex determining region Y)-box 2
SPP1 secreted phosphoprotein 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TNS3 tensin 3
TRIM22 tripartite motif containing 22
TST thiosulfate sulfurtransferase (rhodanese)
VCAM1 vascular cell adhesion molecule 1
VCAN versican
WT1 Wilms tumor 1

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
CCDC86 coiled-coil domain containing 86
CCND1 cyclin D1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
COL4A2 collagen, type IV, alpha 2
CREM cAMP responsive element modulator
DKK1 dickkopf WNT signaling pathway inhibitor 1
DSP desmoplakin
DUSP5 dual specificity phosphatase 5
ELL2 elongation factor, RNA polymerase II, 2
ENO1 enolase 1, (alpha)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GAL galanin/GMAP prepropeptide
HES1 hes family bHLH transcription factor 1
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
ITGA6 integrin, alpha 6
KRT18 keratin 18, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LTF lactotransferrin
MAP2K3 mitogen-activated protein kinase kinase 3
MMP1 matrix metallopeptidase 1
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1X metallothionein 1X
NFIB nuclear factor I/B
PERP PERP, TP53 apoptosis effector
PHLDA2 pleckstrin homology-like domain, family A, member 2
S100A2 S100 calcium binding protein A2
SCML1 sex comb on midleg-like 1 (Drosophila)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SLCO4A1 solute carrier organic anion transporter family, member 4A1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX1A syntaxin 1A (brain)
TMEM2 transmembrane protein 2
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1