BRD-K37393297_1-(3,4-Dihydroxy-phenyl)-2-(4,6-dimethyl-pyrimidin-2-ylsulfanyl)-ethanone_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

126 genes differentially expressed following the BRD-K37393297_1-(3,4-Dihydroxy-phenyl)-2-(4,6-dimethyl-pyrimidin-2-ylsulfanyl)-ethanone_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AMIGO2 adhesion molecule with Ig-like domain 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BEX4 brain expressed, X-linked 4
C1QB complement component 1, q subcomponent, B chain
C1R complement component 1, r subcomponent
C3ORF14 chromosome 3 open reading frame 14
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CD163 CD163 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHMP4A charged multivesicular body protein 4A
CLU clusterin
CNIH4 cornichon family AMPA receptor auxiliary protein 4
CP ceruloplasmin (ferroxidase)
CPE carboxypeptidase E
CTGF connective tissue growth factor
CXCL14 chemokine (C-X-C motif) ligand 14
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DPYSL2 dihydropyrimidinase-like 2
DUSP1 dual specificity phosphatase 1
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
ETV5 ets variant 5
FOLR1 folate receptor 1 (adult)
FSD1 fibronectin type III and SPRY domain containing 1
GAS1 growth arrest-specific 1
HBEGF heparin-binding EGF-like growth factor
HDAC9 histone deacetylase 9
HIST1H2AC histone cluster 1, H2ac
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDO1 indoleamine 2,3-dioxygenase 1
IL32 interleukin 32
KCNK3 potassium channel, two pore domain subfamily K, member 3
LAPTM4B lysosomal protein transmembrane 4 beta
LMO3 LIM domain only 3 (rhombotin-like 2)
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MAT2A methionine adenosyltransferase II, alpha
MCOLN1 mucolipin 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NRCAM neuronal cell adhesion molecule
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCSK1 proprotein convertase subtilisin/kexin type 1
PDPN podoplanin
PDZD2 PDZ domain containing 2
PI3 peptidase inhibitor 3, skin-derived
PNMA2 paraneoplastic Ma antigen 2
PRKCI protein kinase C, iota
PXDN peroxidasin
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RND3 Rho family GTPase 3
RYBP RING1 and YY1 binding protein
S100A8 S100 calcium binding protein A8
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLPI secretory leukocyte peptidase inhibitor
SNX7 sorting nexin 7
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SQSTM1 sequestosome 1
STAB1 stabilin 1
TCF4 transcription factor 4
TM4SF1 transmembrane 4 L six family member 1
TSPAN13 tetraspanin 13
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WT1 Wilms tumor 1

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABHD2 abhydrolase domain containing 2
ACSL1 acyl-CoA synthetase long-chain family member 1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
C2CD2 C2 calcium-dependent domain containing 2
CASP2 caspase 2, apoptosis-related cysteine peptidase
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CYBA cytochrome b-245, alpha polypeptide
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DMD dystrophin
DSP desmoplakin
EI24 etoposide induced 2.4
EPHA3 EPH receptor A3
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FXYD3 FXYD domain containing ion transport regulator 3
GLUD1 glutamate dehydrogenase 1
HMG20B high mobility group 20B
HOXC6 homeobox C6
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KLK11 kallikrein-related peptidase 11
LDHB lactate dehydrogenase B
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAMLD1 mastermind-like domain containing 1
MBP myelin basic protein
MGP matrix Gla protein
MSMB microseminoprotein, beta-
NAV3 neuron navigator 3
NME4 NME/NM23 nucleoside diphosphate kinase 4
PEBP1 phosphatidylethanolamine binding protein 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRAME preferentially expressed antigen in melanoma
PRKCA protein kinase C, alpha
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
SELL selectin L
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SMS spermine synthase
SORD sorbitol dehydrogenase
TACSTD2 tumor-associated calcium signal transducer 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TGFBR3 transforming growth factor, beta receptor III
TLR4 toll-like receptor 4
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
ZNF106 zinc finger protein 106