BRD-K37289225_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

78 genes differentially expressed following the BRD-K37289225_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACP5 acid phosphatase 5, tartrate resistant
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AQP3 aquaporin 3 (Gill blood group)
BASP1 brain abundant, membrane attached signal protein 1
CCL13 chemokine (C-C motif) ligand 13
CCNG2 cyclin G2
CHMP4A charged multivesicular body protein 4A
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CTSK cathepsin K
CXCL14 chemokine (C-X-C motif) ligand 14
DHCR24 24-dehydrocholesterol reductase
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
ECM1 extracellular matrix protein 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FST follistatin
GLS glutaminase
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
KRT17 keratin 17, type I
MCOLN1 mucolipin 1
MSMO1 methylsterol monooxygenase 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NEU1 sialidase 1 (lysosomal sialidase)
NPY1R neuropeptide Y receptor Y1
OPN3 opsin 3
PDLIM2 PDZ and LIM domain 2 (mystique)
PTGES prostaglandin E synthase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RBM3 RNA binding motif (RNP1, RRM) protein 3
RNF167 ring finger protein 167
SCD stearoyl-CoA desaturase (delta-9-desaturase)
STX1A syntaxin 1A (brain)
TFPI2 tissue factor pathway inhibitor 2
TXNDC9 thioredoxin domain containing 9
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ADRB2 adrenoceptor beta 2, surface
ANOS1 anosmin 1
CCND2 cyclin D2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
CYBB cytochrome b-245, beta polypeptide
DLK1 delta-like 1 homolog (Drosophila)
DPYSL3 dihydropyrimidinase-like 3
EIF5A eukaryotic translation initiation factor 5A
ELANE elastase, neutrophil expressed
FABP1 fatty acid binding protein 1, liver
FAM198B family with sequence similarity 198, member B
FCGBP Fc fragment of IgG binding protein
GYG1 glycogenin 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP7 insulin-like growth factor binding protein 7
ITGA6 integrin, alpha 6
ITM2A integral membrane protein 2A
KRT13 keratin 13, type I
KRT19 keratin 19, type I
KRT8 keratin 8, type II
LAPTM5 lysosomal protein transmembrane 5
LTF lactotransferrin
MAGEA3 melanoma antigen family A3
MXRA7 matrix-remodelling associated 7
PTCH1 patched 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PUF60 poly-U binding splicing factor 60KDa
PXDN peroxidasin
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPLP2 ribosomal protein, large, P2
RPS11 ribosomal protein S11
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRSF6 serine/arginine-rich splicing factor 6
TLR4 toll-like receptor 4
TNIK TRAF2 and NCK interacting kinase
TNNC1 troponin C type 1 (slow)
ZNF586 zinc finger protein 586