BRD-K36772364_8-{[2-oxo-2-(1-pyrrolidinyl)ethyl]thio}quinoline_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

111 genes differentially expressed following the BRD-K36772364_8-{[2-oxo-2-(1-pyrrolidinyl)ethyl]thio}quinoline_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALOX5 arachidonate 5-lipoxygenase
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
AUTS2 autism susceptibility candidate 2
C5AR1 complement component 5a receptor 1
CD163 CD163 molecule
CD52 CD52 molecule
CDA cytidine deaminase
CEMIP cell migration inducing protein, hyaluronan binding
CFD complement factor D (adipsin)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLU clusterin
COL5A1 collagen, type V, alpha 1
COTL1 coactosin-like F-actin binding protein 1
CTSB cathepsin B
CTSS cathepsin S
CXCL8 chemokine (C-X-C motif) ligand 8
CYTIP cytohesin 1 interacting protein
DDHD2 DDHD domain containing 2
DDIT4 DNA-damage-inducible transcript 4
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
ELANE elastase, neutrophil expressed
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FTH1 ferritin, heavy polypeptide 1
HIST1H2AC histone cluster 1, H2ac
HMOX1 heme oxygenase 1
HP haptoglobin
IL1R1 interleukin 1 receptor, type I
INSIG1 insulin induced gene 1
KLF4 Kruppel-like factor 4 (gut)
LBH limb bud and heart development
LCN2 lipocalin 2
LEF1 lymphoid enhancer-binding factor 1
LPIN2 lipin 2
LSM1 LSM1, U6 small nuclear RNA associated
LY75 lymphocyte antigen 75
MCOLN1 mucolipin 1
NEFH neurofilament, heavy polypeptide
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLAUR plasminogen activator, urokinase receptor
PRKCB protein kinase C, beta
PSAT1 phosphoserine aminotransferase 1
RBP4 retinol binding protein 4, plasma
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RGCC regulator of cell cycle
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELENBP1 selenium binding protein 1
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLPI secretory leukocyte peptidase inhibitor
SNAI2 snail family zinc finger 2
TREM1 triggering receptor expressed on myeloid cells 1
TXNIP thioredoxin interacting protein
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
XYLT1 xylosyltransferase I
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ARMCX1 armadillo repeat containing, X-linked 1
CCDC86 coiled-coil domain containing 86
CD58 CD58 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CPE carboxypeptidase E
CXADR coxsackie virus and adenovirus receptor
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
FHL1 four and a half LIM domains 1
FZD6 frizzled class receptor 6
GATA3 GATA binding protein 3
GOLGA8H golgin A8 family, member H
GRB7 growth factor receptor-bound protein 7
GREM1 gremlin 1, DAN family BMP antagonist
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HES1 hes family bHLH transcription factor 1
MTUS1 microtubule associated tumor suppressor 1
MYBPC1 myosin binding protein C, slow type
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
NFIB nuclear factor I/B
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NPY1R neuropeptide Y receptor Y1
OXA1L oxidase (cytochrome c) assembly 1-like
PCCB propionyl CoA carboxylase, beta polypeptide
PDLIM3 PDZ and LIM domain 3
PGAP3 post-GPI attachment to proteins 3
PLN phospholamban
POSTN periostin, osteoblast specific factor
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PWP1 PWP1 homolog (S. cerevisiae)
RALGDS ral guanine nucleotide dissociation stimulator
RFTN1 raftlin, lipid raft linker 1
RGS5 regulator of G-protein signaling 5
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
TFF1 trefoil factor 1
THAP11 THAP domain containing 11
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TJP2 tight junction protein 2
TSPAN7 tetraspanin 7
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF512B zinc finger protein 512B