BRD-K36772364_8-{[2-oxo-2-(1-pyrrolidinyl)ethyl]thio}quinoline_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

59 genes differentially expressed following the BRD-K36772364_8-{[2-oxo-2-(1-pyrrolidinyl)ethyl]thio}quinoline_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG2 adhesion G protein-coupled receptor G2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
APOD apolipoprotein D
BAG3 BCL2-associated athanogene 3
CASP2 caspase 2, apoptosis-related cysteine peptidase
CAST calpastatin
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD163 CD163 molecule
CDC20 cell division cycle 20
CLIC5 chloride intracellular channel 5
CTGF connective tissue growth factor
CXCL12 chemokine (C-X-C motif) ligand 12
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ETV5 ets variant 5
GLUL glutamate-ammonia ligase
HBB hemoglobin, beta
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IFI27 interferon, alpha-inducible protein 27
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP4 insulin-like growth factor binding protein 4
MARCKS myristoylated alanine-rich protein kinase C substrate
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRN1 neuritin 1
ODC1 ornithine decarboxylase 1
OSBPL10 oxysterol binding protein-like 10
PAX5 paired box 5
PCOLCE2 procollagen C-endopeptidase enhancer 2
PLAU plasminogen activator, urokinase
SEPP1 selenoprotein P, plasma, 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFTPC surfactant protein C
TMEM176B transmembrane protein 176B

decreased expression

Symbol Name
APMAP adipocyte plasma membrane associated protein
CD24 CD24 molecule
GLIPR1 GLI pathogenesis-related 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HMG20B high mobility group 20B
HOPX HOP homeobox
IRF8 interferon regulatory factor 8
KIF5C kinesin family member 5C
KLK8 kallikrein-related peptidase 8
LCN2 lipocalin 2
PBX3 pre-B-cell leukemia homeobox 3
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPRC protein tyrosine phosphatase, receptor type, C
RALGDS ral guanine nucleotide dissociation stimulator
RGS1 regulator of G-protein signaling 1
SOX4 SRY (sex determining region Y)-box 4
SST somatostatin
TSPAN12 tetraspanin 12
XIST X inactive specific transcript (non-protein coding)