BRD-K36772364_8-{[2-oxo-2-(1-pyrrolidinyl)ethyl]thio}quinoline_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

53 genes differentially expressed following the BRD-K36772364_8-{[2-oxo-2-(1-pyrrolidinyl)ethyl]thio}quinoline_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADIRF adipogenesis regulatory factor
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
BGN biglycan
CA12 carbonic anhydrase XII
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L2 chitinase 3-like 2
CPT1A carnitine palmitoyltransferase 1A (liver)
DCN decorin
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSP desmoplakin
G0S2 G0/G1 switch 2
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HMOX1 heme oxygenase 1
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
MAPT microtubule-associated protein tau
PIR pirin (iron-binding nuclear protein)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLIN2 perilipin 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
RBP4 retinol binding protein 4, plasma
SQSTM1 sequestosome 1
TSPYL5 TSPY-like 5
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ASPH aspartate beta-hydroxylase
CCNB2 cyclin B2
CXADR coxsackie virus and adenovirus receptor
FGF13 fibroblast growth factor 13
FST follistatin
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GTPBP8 GTP-binding protein 8 (putative)
HMG20B high mobility group 20B
LY6E lymphocyte antigen 6 complex, locus E
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
NR2F1 nuclear receptor subfamily 2, group F, member 1
NREP neuronal regeneration related protein
PDHX pyruvate dehydrogenase complex, component X
PLAT plasminogen activator, tissue
PLEKHA5 pleckstrin homology domain containing, family A member 5
PSPH phosphoserine phosphatase
PUF60 poly-U binding splicing factor 60KDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STOM stomatin
TMEM2 transmembrane protein 2
YBX3 Y box binding protein 3