BRD-K36740062_GSK-1070916_PC3_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

249 genes differentially expressed following the BRD-K36740062_GSK-1070916_PC3_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACLY ATP citrate lyase
ACTG2 actin, gamma 2, smooth muscle, enteric
ALDOC aldolase C, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
AREG amphiregulin
ASMTL acetylserotonin O-methyltransferase-like
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BASP1 brain abundant, membrane attached signal protein 1
BIRC3 baculoviral IAP repeat containing 3
BZW2 basic leucine zipper and W2 domains 2
CA2 carbonic anhydrase II
CAST calpastatin
CCDC92 coiled-coil domain containing 92
CCNG2 cyclin G2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHGB chromogranin B
CHMP6 charged multivesicular body protein 6
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDND1 claudin domain containing 1
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CYB5A cytochrome b5 type A (microsomal)
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYR61 cysteine-rich, angiogenic inducer, 61
EFNB2 ephrin-B2
EZR ezrin
FABP6 fatty acid binding protein 6, ileal
FADS1 fatty acid desaturase 1
FAM134B family with sequence similarity 134, member B
FAM50A family with sequence similarity 50, member A
FASN fatty acid synthase
FGFR2 fibroblast growth factor receptor 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
G6PD glucose-6-phosphate dehydrogenase
GDF15 growth differentiation factor 15
GRN granulin
H2BFS H2B histone family, member S (pseudogene)
HCP5 HLA complex P5 (non-protein coding)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPCAL1 hippocalcin-like 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDI1 isopentenyl-diphosphate delta isomerase 1
IDS iduronate 2-sulfatase
IFI30 interferon, gamma-inducible protein 30
IFI6 interferon, alpha-inducible protein 6
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
ITM2C integral membrane protein 2C
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLHL24 kelch-like family member 24
KLHL9 kelch-like family member 9
L1CAM L1 cell adhesion molecule
LAMP2 lysosomal-associated membrane protein 2
LDLR low density lipoprotein receptor
LMO3 LIM domain only 3 (rhombotin-like 2)
LRP2 low density lipoprotein receptor-related protein 2
LXN latexin
LY75 lymphocyte antigen 75
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MBOAT7 membrane bound O-acyltransferase domain containing 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MMP12 matrix metallopeptidase 12
MSMO1 methylsterol monooxygenase 1
MYO6 myosin VI
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NPC1 Niemann-Pick disease, type C1
NPIPB3 nuclear pore complex interacting protein family, member B3
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPR1 nuclear protein, transcriptional regulator, 1
OSBPL10 oxysterol binding protein-like 10
PALLD palladin, cytoskeletal associated protein
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PARM1 prostate androgen-regulated mucin-like protein 1
PFKP phosphofructokinase, platelet
PHGDH phosphoglycerate dehydrogenase
PHLDA2 pleckstrin homology-like domain, family A, member 2
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTPN11 protein tyrosine phosphatase, non-receptor type 11
QPCT glutaminyl-peptide cyclotransferase
RABAC1 Rab acceptor 1 (prenylated)
RGS2 regulator of G-protein signaling 2
RTN2 reticulon 2
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SQSTM1 sequestosome 1
STK26 serine/threonine protein kinase 26
SYBU syntabulin (syntaxin-interacting)
SYT1 synaptotagmin I
TARBP1 TAR (HIV-1) RNA binding protein 1
TFEC transcription factor EC
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TMSB15A thymosin beta 15a
TOX3 TOX high mobility group box family member 3
TPD52 tumor protein D52
TPD52L1 tumor protein D52-like 1
TPP1 tripeptidyl peptidase I
TRIM2 tripartite motif containing 2
TSPAN13 tetraspanin 13
TUBA1A tubulin, alpha 1a
TUBB2B tubulin, beta 2B class IIb
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ACSL5 acyl-CoA synthetase long-chain family member 5
ADAM12 ADAM metallopeptidase domain 12
AFP alpha-fetoprotein
AHSG alpha-2-HS-glycoprotein
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALB albumin
AMBP alpha-1-microglobulin/bikunin precursor
ANO1 anoctamin 1, calcium activated chloride channel
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA1 annexin A1
APOA2 apolipoprotein A-II
APOB apolipoprotein B
APOH apolipoprotein H (beta-2-glycoprotein I)
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C3 complement component 3
C4BPA complement component 4 binding protein, alpha
CA12 carbonic anhydrase XII
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD36 CD36 molecule (thrombospondin receptor)
CD93 CD93 molecule
CDK1 cyclin-dependent kinase 1
CETN3 centrin, EF-hand protein, 3
CLDN10 claudin 10
CLEC2B C-type lectin domain family 2, member B
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL5A1 collagen, type V, alpha 1
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COPS7A COP9 signalosome subunit 7A
CORO1A coronin, actin binding protein, 1A
CX3CR1 chemokine (C-X3-C motif) receptor 1
DEFB1 defensin, beta 1
DLK1 delta-like 1 homolog (Drosophila)
DUSP2 dual specificity phosphatase 2
EGFR epidermal growth factor receptor
EREG epiregulin
FAM3C family with sequence similarity 3, member C
FAP fibroblast activation protein, alpha
FLG filaggrin
HDGFRP3 hepatoma-derived growth factor, related protein 3
HLF hepatic leukemia factor
HNMT histamine N-methyltransferase
HP haptoglobin
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI16 interferon, gamma-inducible protein 16
IFI44 interferon-induced protein 44
IFRD2 interferon-related developmental regulator 2
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP3 insulin-like growth factor binding protein 3
IL1R1 interleukin 1 receptor, type I
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
JADE2 jade family PHD finger 2
KIAA0101 KIAA0101
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLK6 kallikrein-related peptidase 6
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LEF1 lymphoid enhancer-binding factor 1
LOR loricrin
LPL lipoprotein lipase
LRRC17 leucine rich repeat containing 17
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MARCKS myristoylated alanine-rich protein kinase C substrate
MELK maternal embryonic leucine zipper kinase
MGST2 microsomal glutathione S-transferase 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MPZL2 myelin protein zero-like 2
MUC16 mucin 16, cell surface associated
NID1 nidogen 1
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
ORM1 orosomucoid 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PDLIM1 PDZ and LIM domain 1
PLAC8 placenta-specific 8
PLBD1 phospholipase B domain containing 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PRKCD protein kinase C, delta
PTX3 pentraxin 3, long
QKI QKI, KH domain containing, RNA binding
RBP4 retinol binding protein 4, plasma
RFTN1 raftlin, lipid raft linker 1
S100A2 S100 calcium binding protein A2
S100A4 S100 calcium binding protein A4
SAMD9 sterile alpha motif domain containing 9
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC43A3 solute carrier family 43, member 3
SLPI secretory leukocyte peptidase inhibitor
SMAD1 SMAD family member 1
SNAI2 snail family zinc finger 2
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPRR1B small proline-rich protein 1B
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TF transferrin
THBS2 thrombospondin 2
TMEM50A transmembrane protein 50A
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNPO1 transportin 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TXNL4B thioredoxin-like 4B
TYRP1 tyrosinase-related protein 1
UBE2E3 ubiquitin-conjugating enzyme E2E 3
VGLL4 vestigial-like family member 4
ZBTB38 zinc finger and BTB domain containing 38
ZFP36L2 ZFP36 ring finger protein-like 2