BRD-K36740062_GSK-1070916_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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87 genes differentially expressed following the BRD-K36740062_GSK-1070916_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADIRF adipogenesis regulatory factor
ALOX15B arachidonate 15-lipoxygenase, type B
AMIGO2 adhesion molecule with Ig-like domain 2
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BASP1 brain abundant, membrane attached signal protein 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC92 coiled-coil domain containing 92
CCNG2 cyclin G2
CIRBP cold inducible RNA binding protein
CLDN3 claudin 3
CRYAB crystallin, alpha B
CTBS chitobiase, di-N-acetyl-
CXCL13 chemokine (C-X-C motif) ligand 13
EIF5A eukaryotic translation initiation factor 5A
EPN2 epsin 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FRZB frizzled-related protein
GNMT glycine N-methyltransferase
GPM6A glycoprotein M6A
GRN granulin
HEATR1 HEAT repeat containing 1
HIST1H2BD histone cluster 1, H2bd
LGALS2 lectin, galactoside-binding, soluble, 2
LOC100505650 uncharacterized LOC100505650
MT1F metallothionein 1F
NLGN4X neuroligin 4, X-linked
NRCAM neuronal cell adhesion molecule
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PHLDA2 pleckstrin homology-like domain, family A, member 2
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPA1 pyrophosphatase (inorganic) 1
RAB29 RAB29, member RAS oncogene family
RTN1 reticulon 1
SLC38A1 solute carrier family 38, member 1
TARBP1 TAR (HIV-1) RNA binding protein 1
TRIP6 thyroid hormone receptor interactor 6
TUSC3 tumor suppressor candidate 3
VDAC1 voltage-dependent anion channel 1
XYLT1 xylosyltransferase I
ZIC1 Zic family member 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALB albumin
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ASPN asporin
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BTBD3 BTB (POZ) domain containing 3
C8ORF4 chromosome 8 open reading frame 4
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CDK4 cyclin-dependent kinase 4
CXCL8 chemokine (C-X-C motif) ligand 8
DLK1 delta-like 1 homolog (Drosophila)
FAM129A family with sequence similarity 129, member A
FGG fibrinogen gamma chain
GCH1 GTP cyclohydrolase 1
GLI2 GLI family zinc finger 2
GPRC5A G protein-coupled receptor, class C, group 5, member A
H1F0 H1 histone family, member 0
HOPX HOP homeobox
HP haptoglobin
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFI16 interferon, gamma-inducible protein 16
LAPTM4B lysosomal protein transmembrane 4 beta
LUM lumican
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MGP matrix Gla protein
MTUS1 microtubule associated tumor suppressor 1
MXRA5 matrix-remodelling associated 5
NSDHL NAD(P) dependent steroid dehydrogenase-like
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PDLIM1 PDZ and LIM domain 1
POSTN periostin, osteoblast specific factor
PTGES prostaglandin E synthase
RAD23B RAD23 homolog B (S. cerevisiae)
RBP1 retinol binding protein 1, cellular
SEPP1 selenoprotein P, plasma, 1
SFRP1 secreted frizzled-related protein 1
SMAD1 SMAD family member 1
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SMCO4 single-pass membrane protein with coiled-coil domains 4
TMEM123 transmembrane protein 123
UBE2E3 ubiquitin-conjugating enzyme E2E 3