BRD-K36740062_GSK-1070916_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

72 genes differentially expressed following the BRD-K36740062_GSK-1070916_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
C6ORF48 chromosome 6 open reading frame 48
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFD complement factor D (adipsin)
COL15A1 collagen, type XV, alpha 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
F13A1 coagulation factor XIII, A1 polypeptide
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GREB1 growth regulation by estrogen in breast cancer 1
HBD hemoglobin, delta
IFI44L interferon-induced protein 44-like
IGF1R insulin-like growth factor 1 receptor
IL6ST interleukin 6 signal transducer
KRT13 keratin 13, type I
LINC00341 long intergenic non-protein coding RNA 341
MME membrane metallo-endopeptidase
MX1 MX dynamin-like GTPase 1
NID1 nidogen 1
NRIP1 nuclear receptor interacting protein 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PPARG peroxisome proliferator-activated receptor gamma
S100P S100 calcium binding protein P
SERINC3 serine incorporator 3
SERINC5 serine incorporator 5
SLC16A6 solute carrier family 16, member 6
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SPTSSA serine palmitoyltransferase, small subunit A
STC1 stanniocalcin 1
TBC1D4 TBC1 domain family, member 4
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TXNIP thioredoxin interacting protein
YBX3 Y box binding protein 3
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
AUTS2 autism susceptibility candidate 2
BHLHE41 basic helix-loop-helix family, member e41
BIRC5 baculoviral IAP repeat containing 5
C2CD5 C2 calcium-dependent domain containing 5
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
GAL galanin/GMAP prepropeptide
GAS1 growth arrest-specific 1
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HSPA2 heat shock 70kDa protein 2
HSPH1 heat shock 105kDa/110kDa protein 1
IGHM immunoglobulin heavy constant mu
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KLK10 kallikrein-related peptidase 10
MMP9 matrix metallopeptidase 9
MN1 meningioma (disrupted in balanced translocation) 1
PDLIM1 PDZ and LIM domain 1
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
RBP1 retinol binding protein 1, cellular
RHOB ras homolog family member B
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLPI secretory leukocyte peptidase inhibitor
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
VNN1 vanin 1