BRD-K36740062_GSK-1070916_MCF7_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

168 genes differentially expressed following the BRD-K36740062_GSK-1070916_MCF7_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACLY ATP citrate lyase
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AGR2 anterior gradient 2
ALDOC aldolase C, fructose-bisphosphate
AREG amphiregulin
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
BEX1 brain expressed, X-linked 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHGB chromogranin B
CIRBP cold inducible RNA binding protein
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COLEC12 collectin sub-family member 12
CTSA cathepsin A
CYR61 cysteine-rich, angiogenic inducer, 61
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP4 dual specificity phosphatase 4
ERBB2 erb-b2 receptor tyrosine kinase 2
FADS2 fatty acid desaturase 2
FAM117A family with sequence similarity 117, member A
FCGBP Fc fragment of IgG binding protein
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GNB5 guanine nucleotide binding protein (G protein), beta 5
GRN granulin
GSN gelsolin
GSTM3 glutathione S-transferase mu 3 (brain)
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL6ST interleukin 6 signal transducer
INSIG1 insulin induced gene 1
ITGA6 integrin, alpha 6
ITGB5 integrin, beta 5
LASP1 LIM and SH3 protein 1
MATN2 matrilin 2
MGP matrix Gla protein
MKRN1 makorin ring finger protein 1
MTCL1 microtubule crosslinking factor 1
MVP major vault protein
MYO6 myosin VI
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
OLFM4 olfactomedin 4
ORAI3 ORAI calcium release-activated calcium modulator 3
OSR2 odd-skipped related transciption factor 2
PCDH9 protocadherin 9
PCGF2 polycomb group ring finger 2
PEG10 paternally expressed 10
PHYH phytanoyl-CoA 2-hydroxylase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PTCH1 patched 1
QPCT glutaminyl-peptide cyclotransferase
RAP1GAP RAP1 GTPase activating protein
RNASET2 ribonuclease T2
RRAGD Ras-related GTP binding D
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEPP1 selenoprotein P, plasma, 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC22A18 solute carrier family 22, member 18
SPATA20 spermatogenesis associated 20
SQRDL sulfide quinone reductase-like (yeast)
SQSTM1 sequestosome 1
SRPX sushi-repeat containing protein, X-linked
STC1 stanniocalcin 1
STON1 stonin 1
STXBP1 syntaxin binding protein 1
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TFF1 trefoil factor 1
TGFBR3 transforming growth factor, beta receptor III
TIMP1 TIMP metallopeptidase inhibitor 1
TOMM34 translocase of outer mitochondrial membrane 34
TXNIP thioredoxin interacting protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCL vinculin
VIM vimentin
WDTC1 WD and tetratricopeptide repeats 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
WLS wntless Wnt ligand secretion mediator
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AK4 adenylate kinase 4
ATAD2 ATPase family, AAA domain containing 2
AUTS2 autism susceptibility candidate 2
BANF1 barrier to autointegration factor 1
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CHEK2 checkpoint kinase 2
CKS1B CDC28 protein kinase regulatory subunit 1B
DBF4 DBF4 zinc finger
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF5 eukaryotic translation initiation factor 5
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRWD1 glutamate-rich WD repeat containing 1
H2AFX H2A histone family, member X
HIST1H4C histone cluster 1, H4c
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM3 intercellular adhesion molecule 3
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLV3-19 immunoglobulin lambda variable 3-19
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
LHX2 LIM homeobox 2
MAL mal, T-cell differentiation protein
MCM5 minichromosome maintenance complex component 5
MELK maternal embryonic leucine zipper kinase
MREG melanoregulin
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYBPC1 myosin binding protein C, slow type
NET1 neuroepithelial cell transforming 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NUSAP1 nucleolar and spindle associated protein 1
PDLIM1 PDZ and LIM domain 1
PITX1 paired-like homeodomain 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
PXMP2 peroxisomal membrane protein 2, 22kDa
RAD51AP1 RAD51 associated protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
S100A7 S100 calcium binding protein A7
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SIVA1 SIVA1, apoptosis-inducing factor
SMC2 structural maintenance of chromosomes 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TUBB tubulin, beta class I
UBE2C ubiquitin-conjugating enzyme E2C
ZMYM2 zinc finger, MYM-type 2
ZWINT ZW10 interacting kinetochore protein