BRD-K36740062_GSK-1070916_HT29_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

161 genes differentially expressed following the BRD-K36740062_GSK-1070916_HT29_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANKRD10 ankyrin repeat domain 10
ARMCX1 armadillo repeat containing, X-linked 1
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ASPH aspartate beta-hydroxylase
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C14ORF132 chromosome 14 open reading frame 132
CALML5 calmodulin-like 5
CAPG capping protein (actin filament), gelsolin-like
CCNG2 cyclin G2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLCN3 chloride channel, voltage-sensitive 3
COL15A1 collagen, type XV, alpha 1
CTGF connective tissue growth factor
CTSA cathepsin A
DDIT3 DNA-damage-inducible transcript 3
DEGS1 delta(4)-desaturase, sphingolipid 1
DUSP1 dual specificity phosphatase 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
F13A1 coagulation factor XIII, A1 polypeptide
FAM50A family with sequence similarity 50, member A
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOXN3 forkhead box N3
FOXO4 forkhead box O4
FZD7 frizzled class receptor 7
GLRX glutaredoxin (thioltransferase)
GNB5 guanine nucleotide binding protein (G protein), beta 5
GPRC5B G protein-coupled receptor, class C, group 5, member B
GRN granulin
GSN gelsolin
GSTM3 glutathione S-transferase mu 3 (brain)
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
JUND jun D proto-oncogene
KIAA1033 KIAA1033
KLF4 Kruppel-like factor 4 (gut)
LGMN legumain
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
MVP major vault protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
PHGDH phosphoglycerate dehydrogenase
PHYH phytanoyl-CoA 2-hydroxylase
PLAU plasminogen activator, urokinase
PNKP polynucleotide kinase 3'-phosphatase
PODXL podocalyxin-like
PROM1 prominin 1
PRSS23 protease, serine, 23
PSPH phosphoserine phosphatase
RRAGD Ras-related GTP binding D
RSRP1 arginine/serine-rich protein 1
RUNX1 runt-related transcription factor 1
SCAND1 SCAN domain containing 1
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFXN3 sideroflexin 3
SORBS3 sorbin and SH3 domain containing 3
SQSTM1 sequestosome 1
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TM7SF2 transmembrane 7 superfamily member 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPP1 tripeptidyl peptidase I
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VWA5A von Willebrand factor A domain containing 5A
ZFYVE26 zinc finger, FYVE domain containing 26
ZMAT3 zinc finger, matrin-type 3
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AADAC arylacetamide deacetylase
APOH apolipoprotein H (beta-2-glycoprotein I)
ATP13A3 ATPase type 13A3
BOP1 block of proliferation 1
BTG3 BTG family, member 3
CCNA2 cyclin A2
CD320 CD320 molecule
CD48 CD48 molecule
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CKS1B CDC28 protein kinase regulatory subunit 1B
CLC Charcot-Leyden crystal galectin
CPA3 carboxypeptidase A3 (mast cell)
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTPS1 CTP synthase 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYCS cytochrome c, somatic
DPH2 DPH2 homolog (S. cerevisiae)
EREG epiregulin
ESR1 estrogen receptor 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GREM1 gremlin 1, DAN family BMP antagonist
GTPBP4 GTP binding protein 4
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IGF1 insulin-like growth factor 1 (somatomedin C)
IL1RN interleukin 1 receptor antagonist
IPO5 importin 5
KRT13 keratin 13, type I
LDHA lactate dehydrogenase A
MAL mal, T-cell differentiation protein
MCM3 minichromosome maintenance complex component 3
MRPL3 mitochondrial ribosomal protein L3
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV3 neuron navigator 3
NME1 NME/NM23 nucleoside diphosphate kinase 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOLC1 nucleolar and coiled-body phosphoprotein 1
ODC1 ornithine decarboxylase 1
PDLIM1 PDZ and LIM domain 1
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PGK1 phosphoglycerate kinase 1
PID1 phosphotyrosine interaction domain containing 1
PLAC8 placenta-specific 8
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PON2 paraoxonase 2
PON3 paraoxonase 3
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RPIA ribose 5-phosphate isomerase A
RRM1 ribonucleotide reductase M1
SERBP1 SERPINE1 mRNA binding protein 1
SLC35F2 solute carrier family 35, member F2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SNRPA1 small nuclear ribonucleoprotein polypeptide A'
SPON1 spondin 1, extracellular matrix protein
SPRR3 small proline-rich protein 3
SRGN serglycin
STEAP1 six transmembrane epithelial antigen of the prostate 1
TCP1 t-complex 1
TFRC transferrin receptor
TSPAN4 tetraspanin 4
UBE2C ubiquitin-conjugating enzyme E2C
YME1L1 YME1-like 1 ATPase