BRD-K36740062_GSK-1070916_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

60 genes differentially expressed following the BRD-K36740062_GSK-1070916_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
BST2 bone marrow stromal cell antigen 2
COTL1 coactosin-like F-actin binding protein 1
HDGFRP3 hepatoma-derived growth factor, related protein 3
KRT7 keratin 7, type II
MT1F metallothionein 1F
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MYO6 myosin VI
S100A11 S100 calcium binding protein A11
SESN1 sestrin 1
SQSTM1 sequestosome 1
TACSTD2 tumor-associated calcium signal transducer 2
TIMP1 TIMP metallopeptidase inhibitor 1
TM4SF1 transmembrane 4 L six family member 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VDAC1 voltage-dependent anion channel 1
VGLL4 vestigial-like family member 4

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BEX1 brain expressed, X-linked 1
CA1 carbonic anhydrase I
CA12 carbonic anhydrase XII
CCL20 chemokine (C-C motif) ligand 20
CCNA2 cyclin A2
CD36 CD36 molecule (thrombospondin receptor)
CEMIP cell migration inducing protein, hyaluronan binding
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
CXCL12 chemokine (C-X-C motif) ligand 12
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EGR3 early growth response 3
GBP1 guanylate binding protein 1, interferon-inducible
HBB hemoglobin, beta
HMGB2 high mobility group box 2
IGFBP5 insulin-like growth factor binding protein 5
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0226L KIAA0226-like
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LPPR4 lipid phosphate phosphatase-related protein type 4
LYZ lysozyme
MN1 meningioma (disrupted in balanced translocation) 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POSTN periostin, osteoblast specific factor
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRC1 protein regulator of cytokinesis 1
PTGER3 prostaglandin E receptor 3 (subtype EP3)
REG3A regenerating islet-derived 3 alpha
RGS5 regulator of G-protein signaling 5
SCG2 secretogranin II
SDC2 syndecan 2
SELENBP1 selenium binding protein 1
TNC tenascin C
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
VEGFA vascular endothelial growth factor A