BRD-K36740062_GSK-1070916_HEPG2_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

87 genes differentially expressed following the BRD-K36740062_GSK-1070916_HEPG2_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATF3 activating transcription factor 3
BIRC3 baculoviral IAP repeat containing 3
BTG3 BTG family, member 3
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DHRS2 dehydrogenase/reductase (SDR family) member 2
FABP4 fatty acid binding protein 4, adipocyte
ICAM1 intercellular adhesion molecule 1
KAT6A K(lysine) acetyltransferase 6A
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LITAF lipopolysaccharide-induced TNF factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MMP7 matrix metallopeptidase 7
MSN moesin
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
NNMT nicotinamide N-methyltransferase
NR1D2 nuclear receptor subfamily 1, group D, member 2
RGCC regulator of cell cycle
RPS27L ribosomal protein S27-like
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SESN1 sestrin 1
SMAD3 SMAD family member 3
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SQSTM1 sequestosome 1
SRPX sushi-repeat containing protein, X-linked
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
THBS1 thrombospondin 1

decreased expression

Symbol Name
ADAM28 ADAM metallopeptidase domain 28
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
AUTS2 autism susceptibility candidate 2
CADM1 cell adhesion molecule 1
CD58 CD58 molecule
CFH complement factor H
COL15A1 collagen, type XV, alpha 1
CTSH cathepsin H
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
DMD dystrophin
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
F13A1 coagulation factor XIII, A1 polypeptide
GBP1 guanylate binding protein 1, interferon-inducible
GRHPR glyoxylate reductase/hydroxypyruvate reductase
GRWD1 glutamate-rich WD repeat containing 1
H2AFX H2A histone family, member X
HOPX HOP homeobox
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IPO13 importin 13
ITM2A integral membrane protein 2A
KLF4 Kruppel-like factor 4 (gut)
LMO4 LIM domain only 4
LTF lactotransferrin
MBNL2 muscleblind-like splicing regulator 2
MMP2 matrix metallopeptidase 2
MN1 meningioma (disrupted in balanced translocation) 1
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
NDRG1 N-myc downstream regulated 1
PCNA proliferating cell nuclear antigen
PCP4 Purkinje cell protein 4
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PXMP2 peroxisomal membrane protein 2, 22kDa
RGS13 regulator of G-protein signaling 13
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCRG1 stimulator of chondrogenesis 1
SHB Src homology 2 domain containing adaptor protein B
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
STAT1 signal transducer and activator of transcription 1, 91kDa
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TMEM176B transmembrane protein 176B
TMEM97 transmembrane protein 97
TNNT1 troponin T type 1 (skeletal, slow)
TPD52L1 tumor protein D52-like 1
TYMS thymidylate synthetase