BRD-K36740062_GSK-1070916_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

95 genes differentially expressed following the BRD-K36740062_GSK-1070916_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP12 A kinase (PRKA) anchor protein 12
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
BLVRB biliverdin reductase B
BZW2 basic leucine zipper and W2 domains 2
CENPE centromere protein E, 312kDa
CLGN calmegin
CRISP3 cysteine-rich secretory protein 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCR4 chemokine (C-X-C motif) receptor 4
DEFB1 defensin, beta 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
HMG20B high mobility group 20B
HMOX1 heme oxygenase 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KRT15 keratin 15, type I
LCN2 lipocalin 2
MSMB microseminoprotein, beta-
PHGDH phosphoglycerate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
RGCC regulator of cell cycle
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SIK1 salt-inducible kinase 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
TMSB15A thymosin beta 15a
TSC22D3 TSC22 domain family, member 3
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
ADCK3 aarF domain containing kinase 3
AK4 adenylate kinase 4
AMIGO2 adhesion molecule with Ig-like domain 2
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BEX1 brain expressed, X-linked 1
CCL2 chemokine (C-C motif) ligand 2
CCND2 cyclin D2
CD200 CD200 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHN1 chimerin 1
CHN2 chimerin 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
CPE carboxypeptidase E
CXADR coxsackie virus and adenovirus receptor
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP6 dual specificity phosphatase 6
EMP3 epithelial membrane protein 3
ENO1 enolase 1, (alpha)
FAM162A family with sequence similarity 162, member A
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FOS FBJ murine osteosarcoma viral oncogene homolog
GTPBP8 GTP-binding protein 8 (putative)
HAPLN1 hyaluronan and proteoglycan link protein 1
HIST1H4C histone cluster 1, H4c
IGHM immunoglobulin heavy constant mu
ITM2A integral membrane protein 2A
JAG1 jagged 1
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
L1TD1 LINE-1 type transposase domain containing 1
LEFTY1 left-right determination factor 1
MSH6 mutS homolog 6
NELL2 NEL-like 2 (chicken)
NPTX1 neuronal pentraxin I
NUTF2 nuclear transport factor 2
PEG3 paternally expressed 3
PGAM1 phosphoglycerate mutase 1 (brain)
PID1 phosphotyrosine interaction domain containing 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POSTN periostin, osteoblast specific factor
PTMA prothymosin, alpha
QPRT quinolinate phosphoribosyltransferase
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBM34 RNA binding motif protein 34
RBP1 retinol binding protein 1, cellular
RGS5 regulator of G-protein signaling 5
RPS11 ribosomal protein S11
S100A10 S100 calcium binding protein A10
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP1 secreted frizzled-related protein 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SMYD2 SET and MYND domain containing 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TF transferrin
TGFBI transforming growth factor, beta-induced, 68kDa
TPPP3 tubulin polymerization-promoting protein family member 3
VCAN versican
VSNL1 visinin-like 1