BRD-K36740062_GSK-1070916_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

80 genes differentially expressed following the BRD-K36740062_GSK-1070916_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL3 acyl-CoA synthetase long-chain family member 3
BCAT1 branched chain amino-acid transaminase 1, cytosolic
C1QB complement component 1, q subcomponent, B chain
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLGN calmegin
CLIC4 chloride intracellular channel 4
COPA coatomer protein complex, subunit alpha
CTSD cathepsin D
CXCL8 chemokine (C-X-C motif) ligand 8
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
FAM129A family with sequence similarity 129, member A
H2BFS H2B histone family, member S (pseudogene)
HIST1H2BK histone cluster 1, H2bk
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HMOX1 heme oxygenase 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
LAPTM4B lysosomal protein transmembrane 4 beta
LMO3 LIM domain only 3 (rhombotin-like 2)
MCL1 myeloid cell leukemia 1
PSAT1 phosphoserine aminotransferase 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPN12 protein tyrosine phosphatase, non-receptor type 12
SCARB2 scavenger receptor class B, member 2
SOCS2 suppressor of cytokine signaling 2
SQSTM1 sequestosome 1
THBS1 thrombospondin 1
TWSG1 twisted gastrulation BMP signaling modulator 1

decreased expression

Symbol Name
ADA adenosine deaminase
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
AMD1 adenosylmethionine decarboxylase 1
CA12 carbonic anhydrase XII
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
DACT1 dishevelled-binding antagonist of beta-catenin 1
DLK1 delta-like 1 homolog (Drosophila)
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FERMT1 fermitin family member 1
FKBP11 FK506 binding protein 11, 19 kDa
GUSBP11 glucuronidase, beta pseudogene 11
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
JAM3 junctional adhesion molecule 3
JCHAIN joining chain of multimeric IgA and IgM
KRT14 keratin 14, type I
KRT19 keratin 19, type I
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LTF lactotransferrin
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MCM4 minichromosome maintenance complex component 4
MTA1 metastasis associated 1
NEBL nebulette
NOP56 NOP56 ribonucleoprotein
PCNA proliferating cell nuclear antigen
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POU2AF1 POU class 2 associating factor 1
RGS5 regulator of G-protein signaling 5
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RSL1D1 ribosomal L1 domain containing 1
S100A12 S100 calcium binding protein A12
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SNRPE small nuclear ribonucleoprotein polypeptide E
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRSF6 serine/arginine-rich splicing factor 6
STK26 serine/threonine protein kinase 26
TLR4 toll-like receptor 4
TSPAN7 tetraspanin 7
UCK2 uridine-cytidine kinase 2
VCAN versican
VSNL1 visinin-like 1