BRD-K36740062_GSK-1070916_HA1E_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

218 genes differentially expressed following the BRD-K36740062_GSK-1070916_HA1E_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
AREG amphiregulin
ASMTL acetylserotonin O-methyltransferase-like
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BAD BCL2-associated agonist of cell death
BPHL biphenyl hydrolase-like (serine hydrolase)
BSG basigin (Ok blood group)
BTG2 BTG family, member 2
C9ORF16 chromosome 9 open reading frame 16
CASP1 caspase 1, apoptosis-related cysteine peptidase
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CES1 carboxylesterase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COLEC12 collectin sub-family member 12
CPD carboxypeptidase D
CREG1 cellular repressor of E1A-stimulated genes 1
CTSA cathepsin A
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
EIF4B eukaryotic translation initiation factor 4B
EMP2 epithelial membrane protein 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EXPH5 exophilin 5
FBLN1 fibulin 1
FBN2 fibrillin 2
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
FTH1 ferritin, heavy polypeptide 1
GAGE3 G antigen 3
GBAP1 glucosidase, beta, acid pseudogene 1
GLDC glycine dehydrogenase (decarboxylating)
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
GPX4 glutathione peroxidase 4
H1F0 H1 histone family, member 0
H1FX H1 histone family, member X
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP5 insulin-like growth factor binding protein 5
IL1R1 interleukin 1 receptor, type I
INSIG1 insulin induced gene 1
KLHL24 kelch-like family member 24
LMO3 LIM domain only 3 (rhombotin-like 2)
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MTUS1 microtubule associated tumor suppressor 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NQO1 NAD(P)H dehydrogenase, quinone 1
NUPR1 nuclear protein, transcriptional regulator, 1
OSR2 odd-skipped related transciption factor 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDH9 protocadherin 9
PEG10 paternally expressed 10
PHGDH phosphoglycerate dehydrogenase
PLA2G16 phospholipase A2, group XVI
PPL periplakin
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTEN phosphatase and tensin homolog
PTN pleiotrophin
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS2 regulator of G-protein signaling 2
RTN3 reticulon 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TKT transketolase
TM7SF2 transmembrane 7 superfamily member 2
TM9SF3 transmembrane 9 superfamily member 3
TPBG trophoblast glycoprotein
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
WLS wntless Wnt ligand secretion mediator
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACTA1 actin, alpha 1, skeletal muscle
ACTN1 actinin, alpha 1
ADAM12 ADAM metallopeptidase domain 12
AK4 adenylate kinase 4
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA3 annexin A3
AXL AXL receptor tyrosine kinase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BACE2 beta-site APP-cleaving enzyme 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CCL2 chemokine (C-C motif) ligand 2
CD58 CD58 molecule
CD59 CD59 molecule, complement regulatory protein
CD69 CD69 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CFLAR CASP8 and FADD-like apoptosis regulator
CNN3 calponin 3, acidic
COL5A1 collagen, type V, alpha 1
CTGF connective tissue growth factor
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
CYCS cytochrome c, somatic
CYTL1 cytokine-like 1
DHRS7 dehydrogenase/reductase (SDR family) member 7
DLK1 delta-like 1 homolog (Drosophila)
DSC2 desmocollin 2
EDN1 endothelin 1
EIF5 eukaryotic translation initiation factor 5
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHB2 EPH receptor B2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
GBE1 glucan (1,4-alpha-), branching enzyme 1
GBP1 guanylate binding protein 1, interferon-inducible
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLIPR1 GLI pathogenesis-related 1
GTF3A general transcription factor IIIA
GZMK granzyme K (granzyme 3; tryptase II)
HBEGF heparin-binding EGF-like growth factor
HOMER2 homer scaffolding protein 2
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IL32 interleukin 32
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KRT10 keratin 10, type I
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
LOX lysyl oxidase
LRRC59 leucine rich repeat containing 59
LTBP2 latent transforming growth factor beta binding protein 2
LXN latexin
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MARCKS myristoylated alanine-rich protein kinase C substrate
MBNL2 muscleblind-like splicing regulator 2
MDFIC MyoD family inhibitor domain containing
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MOK MOK protein kinase
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBPC1 myosin binding protein C, slow type
NET1 neuroepithelial cell transforming 1
NKX3-1 NK3 homeobox 1
NME1 NME/NM23 nucleoside diphosphate kinase 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PADI2 peptidyl arginine deiminase, type II
PDGFC platelet derived growth factor C
PGK1 phosphoglycerate kinase 1
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAGL1 pleiomorphic adenoma gene-like 1
PLBD1 phospholipase B domain containing 1
PON2 paraoxonase 2
PRDX4 peroxiredoxin 4
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PYCR1 pyrroline-5-carboxylate reductase 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RGS4 regulator of G-protein signaling 4
RHOB ras homolog family member B
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S100A2 S100 calcium binding protein A2
SACS sacsin molecular chaperone
SEC61G Sec61 gamma subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC22A3 solute carrier family 22 (organic cation transporter), member 3
SMYD2 SET and MYND domain containing 2
SOX9 SRY (sex determining region Y)-box 9
SPHK1 sphingosine kinase 1
SRGN serglycin
STK17A serine/threonine kinase 17a
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TMEM47 transmembrane protein 47
TNC tenascin C
TPI1 triosephosphate isomerase 1
TPM1 tropomyosin 1 (alpha)
TPM4 tropomyosin 4
TRAF5 TNF receptor-associated factor 5
TRIB2 tribbles pseudokinase 2
TSPAN13 tetraspanin 13
TSPO translocator protein (18kDa)
TXNDC9 thioredoxin domain containing 9
VDAC1 voltage-dependent anion channel 1
VLDLR very low density lipoprotein receptor
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
WDR7 WD repeat domain 7
WSB2 WD repeat and SOCS box containing 2
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZNF274 zinc finger protein 274