BRD-K36740062_GSK-1070916_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

86 genes differentially expressed following the BRD-K36740062_GSK-1070916_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AIM1 absent in melanoma 1
APOD apolipoprotein D
AREG amphiregulin
BEX4 brain expressed, X-linked 4
CA2 carbonic anhydrase II
CD24 CD24 molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
CRELD2 cysteine-rich with EGF-like domains 2
DSP desmoplakin
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FCGBP Fc fragment of IgG binding protein
FXYD6 FXYD domain containing ion transport regulator 6
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GPRC5B G protein-coupled receptor, class C, group 5, member B
H2BFS H2B histone family, member S (pseudogene)
HIST1H2BK histone cluster 1, H2bk
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
KLF4 Kruppel-like factor 4 (gut)
LEF1 lymphoid enhancer-binding factor 1
LTF lactotransferrin
MAPT microtubule-associated protein tau
MATN2 matrilin 2
METTL7A methyltransferase like 7A
NRN1 neuritin 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PIH1D1 PIH1 domain containing 1
PKP2 plakophilin 2
PLBD1 phospholipase B domain containing 1
PLS1 plastin 1
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
S100A9 S100 calcium binding protein A9
SPTSSA serine palmitoyltransferase, small subunit A
TARBP1 TAR (HIV-1) RNA binding protein 1
TFF1 trefoil factor 1
TGFBR3 transforming growth factor, beta receptor III
TOB1 transducer of ERBB2, 1
TRIB2 tribbles pseudokinase 2
TUBB2A tubulin, beta 2A class IIa
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)

decreased expression

Symbol Name
APOL1 apolipoprotein L, 1
ARG2 arginase 2
C8ORF4 chromosome 8 open reading frame 4
CCL2 chemokine (C-C motif) ligand 2
CD38 CD38 molecule
CP ceruloplasmin (ferroxidase)
CTSB cathepsin B
CTSC cathepsin C
ERAP2 endoplasmic reticulum aminopeptidase 2
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GDF15 growth differentiation factor 15
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
LY6E lymphocyte antigen 6 complex, locus E
MSLN mesothelin
NDNF neuron-derived neurotrophic factor
NRCAM neuronal cell adhesion molecule
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCP4 Purkinje cell protein 4
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PRKACB protein kinase, cAMP-dependent, catalytic, beta
RHOQ ras homolog family member Q
S100A11 S100 calcium binding protein A11
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOCS2 suppressor of cytokine signaling 2
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STOM stomatin
TBX3 T-box 3
TESC tescalcin
TLE4 transducin-like enhancer of split 4
TNNC1 troponin C type 1 (slow)
VDAC1 voltage-dependent anion channel 1
VLDLR very low density lipoprotein receptor
ZNF274 zinc finger protein 274