BRD-K36740062_GSK-1070916_A549_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

58 genes differentially expressed following the BRD-K36740062_GSK-1070916_A549_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ANXA4 annexin A4
AREG amphiregulin
BAX BCL2-associated X protein
BTG2 BTG family, member 2
CCND2 cyclin D2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLCA2 chloride channel accessory 2
COL4A5 collagen, type IV, alpha 5
CREG1 cellular repressor of E1A-stimulated genes 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DDB2 damage-specific DNA binding protein 2, 48kDa
DFNA5 deafness, autosomal dominant 5
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
GADD45A growth arrest and DNA-damage-inducible, alpha
LDOC1 leucine zipper, down-regulated in cancer 1
NEBL nebulette
NEU1 sialidase 1 (lysosomal sialidase)
ORAI3 ORAI calcium release-activated calcium modulator 3
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SCPEP1 serine carboxypeptidase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SMAD3 SMAD family member 3
SPATA20 spermatogenesis associated 20
TFF1 trefoil factor 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TP53I3 tumor protein p53 inducible protein 3
TRIM22 tripartite motif containing 22
TSPAN4 tetraspanin 4
ZMAT3 zinc finger, matrin-type 3
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AEBP1 AE binding protein 1
AKAP12 A kinase (PRKA) anchor protein 12
BRCA1 breast cancer 1, early onset
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CHEK1 checkpoint kinase 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A2 collagen, type VI, alpha 2
CXCL14 chemokine (C-X-C motif) ligand 14
DSCC1 DNA replication and sister chromatid cohesion 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
KIF18B kinesin family member 18B
MT1M metallothionein 1M
PCSK1 proprotein convertase subtilisin/kexin type 1
PLTP phospholipid transfer protein
RBP1 retinol binding protein 1, cellular
UNG uracil-DNA glycosylase
USP1 ubiquitin specific peptidase 1
VTCN1 V-set domain containing T cell activation inhibitor 1