BRD-K36740062_GSK-1070916_A549_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

57 genes differentially expressed following the BRD-K36740062_GSK-1070916_A549_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
BAX BCL2-associated X protein
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLU clusterin
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
CPE carboxypeptidase E
CSTA cystatin A (stefin A)
DDB2 damage-specific DNA binding protein 2, 48kDa
DFNA5 deafness, autosomal dominant 5
DUSP6 dual specificity phosphatase 6
FAS Fas cell surface death receptor
FBN2 fibrillin 2
GADD45A growth arrest and DNA-damage-inducible, alpha
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
MYOF myoferlin
NPEPL1 aminopeptidase-like 1
PERP PERP, TP53 apoptosis effector
PLXNB2 plexin B2
PON2 paraoxonase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RFX5 regulatory factor X, 5 (influences HLA class II expression)
SESN1 sestrin 1
SLC38A1 solute carrier family 38, member 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TP53I3 tumor protein p53 inducible protein 3
TRIM22 tripartite motif containing 22
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ASPN asporin
CCK cholecystokinin
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL14 chemokine (C-X-C motif) ligand 14
FMO2 flavin containing monooxygenase 2 (non-functional)
LPL lipoprotein lipase
MAGEB2 melanoma antigen family B2
MARCKSL1 MARCKS-like 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
PODXL podocalyxin-like
RBP1 retinol binding protein 1, cellular
TNS1 tensin 1
USP1 ubiquitin specific peptidase 1