BRD-K36740062_GSK-1070916_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

145 genes differentially expressed following the BRD-K36740062_GSK-1070916_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ASCL1 achaete-scute family bHLH transcription factor 1
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
AVPI1 arginine vasopressin-induced 1
BTG2 BTG family, member 2
C6ORF48 chromosome 6 open reading frame 48
CAPN3 calpain 3, (p94)
CCND2 cyclin D2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEMIP cell migration inducing protein, hyaluronan binding
CSRP1 cysteine and glycine-rich protein 1
CTSL cathepsin L
CYBA cytochrome b-245, alpha polypeptide
DDB2 damage-specific DNA binding protein 2, 48kDa
DEPTOR DEP domain containing MTOR-interacting protein
DUSP10 dual specificity phosphatase 10
DUSP4 dual specificity phosphatase 4
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
ENOSF1 enolase superfamily member 1
FAS Fas cell surface death receptor
FBN2 fibrillin 2
FDXR ferredoxin reductase
FOXJ3 forkhead box J3
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GPX2 glutathione peroxidase 2
H2BFS H2B histone family, member S (pseudogene)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HOXD1 homeobox D1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IGF1R insulin-like growth factor 1 receptor
KYNU kynureninase
LAP3 leucine aminopeptidase 3
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOC100272216 uncharacterized LOC100272216
MAN1C1 mannosidase, alpha, class 1C, member 1
MLANA melan-A
MSRB2 methionine sulfoxide reductase B2
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
NNMT nicotinamide N-methyltransferase
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
PCCB propionyl CoA carboxylase, beta polypeptide
PFKM phosphofructokinase, muscle
PRPF4 pre-mRNA processing factor 4
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAB29 RAB29, member RAS oncogene family
RALGDS ral guanine nucleotide dissociation stimulator
REEP5 receptor accessory protein 5
RFTN1 raftlin, lipid raft linker 1
RPS27L ribosomal protein S27-like
SC5D sterol-C5-desaturase
SCAND1 SCAN domain containing 1
SCCPDH saccharopine dehydrogenase (putative)
SCG5 secretogranin V
SESN1 sestrin 1
SQSTM1 sequestosome 1
TFF3 trefoil factor 3 (intestinal)
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRIM22 tripartite motif containing 22
WARS tryptophanyl-tRNA synthetase
ZMAT3 zinc finger, matrin-type 3
ZNF586 zinc finger protein 586
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA1 annexin A1
ANXA3 annexin A3
ARHGAP29 Rho GTPase activating protein 29
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BRCA1 breast cancer 1, early onset
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CCL2 chemokine (C-C motif) ligand 2
CD59 CD59 molecule, complement regulatory protein
CENPU centromere protein U
CHEK1 checkpoint kinase 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRISP3 cysteine-rich secretory protein 3
CXCL5 chemokine (C-X-C motif) ligand 5
DAXX death-domain associated protein
DCK deoxycytidine kinase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNA2 DNA replication helicase/nuclease 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSC2 desmocollin 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHA3 EPH receptor A3
GINS3 GINS complex subunit 3 (Psf3 homolog)
GLIPR1 GLI pathogenesis-related 1
GPC3 glypican 3
GPM6A glycoprotein M6A
GRWD1 glutamate-rich WD repeat containing 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL1R2 interleukin 1 receptor, type II
IQCG IQ motif containing G
JADE2 jade family PHD finger 2
KIF18B kinesin family member 18B
KRT19 keratin 19, type I
LPL lipoprotein lipase
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MCM10 minichromosome maintenance complex component 10
METRN meteorin, glial cell differentiation regulator
MGP matrix Gla protein
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NRN1 neuritin 1
PHACTR2 phosphatase and actin regulator 2
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
RAB25 RAB25, member RAS oncogene family
RAD51AP1 RAD51 associated protein 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RNASE4 ribonuclease, RNase A family, 4
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLIT2 slit homolog 2 (Drosophila)
SORBS3 sorbin and SH3 domain containing 3
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPC25 SPC25, NDC80 kinetochore complex component
STMN1 stathmin 1
TACC1 transforming, acidic coiled-coil containing protein 1
TACSTD2 tumor-associated calcium signal transducer 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TM4SF1 transmembrane 4 L six family member 1
TPM1 tropomyosin 1 (alpha)
UNG uracil-DNA glycosylase
VCAM1 vascular cell adhesion molecule 1
WASF3 WAS protein family, member 3