BRD-K36740062_GSK-1070916_A375_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

223 genes differentially expressed following the BRD-K36740062_GSK-1070916_A375_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACBD3 acyl-CoA binding domain containing 3
AHNAK2 AHNAK nucleoprotein 2
ANXA9 annexin A9
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BEX4 brain expressed, X-linked 4
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
BZW2 basic leucine zipper and W2 domains 2
C14ORF132 chromosome 14 open reading frame 132
CAPN3 calpain 3, (p94)
CCDC92 coiled-coil domain containing 92
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CERS6 ceramide synthase 6
CFD complement factor D (adipsin)
CHMP1B charged multivesicular body protein 1B
CLCN3 chloride channel, voltage-sensitive 3
COL4A5 collagen, type IV, alpha 5
CSNK1A1 casein kinase 1, alpha 1
CST1 cystatin SN
CTSA cathepsin A
CYB5A cytochrome b5 type A (microsomal)
CYFIP2 cytoplasmic FMR1 interacting protein 2
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DHCR24 24-dehydrocholesterol reductase
DUSP10 dual specificity phosphatase 10
EIF5A eukaryotic translation initiation factor 5A
FADS1 fatty acid desaturase 1
FAM63A family with sequence similarity 63, member A
FDXR ferredoxin reductase
FN1 fibronectin 1
GABARAP GABA(A) receptor-associated protein
GAS1 growth arrest-specific 1
GAS6 growth arrest-specific 6
GATA3 GATA binding protein 3
GDF15 growth differentiation factor 15
GDI1 GDP dissociation inhibitor 1
GHR growth hormone receptor
GPX2 glutathione peroxidase 2
GREM1 gremlin 1, DAN family BMP antagonist
H2BFS H2B histone family, member S (pseudogene)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDS iduronate 2-sulfatase
INSIG1 insulin induced gene 1
JARID2 jumonji, AT rich interactive domain 2
KRT15 keratin 15, type I
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LOC100272216 uncharacterized LOC100272216
LOC399491
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAPT microtubule-associated protein tau
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MID1IP1 MID1 interacting protein 1
MRPL40 mitochondrial ribosomal protein L40
MSMO1 methylsterol monooxygenase 1
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYO6 myosin VI
NARS asparaginyl-tRNA synthetase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NPC2 Niemann-Pick disease, type C2
NPIPB3 nuclear pore complex interacting protein family, member B3
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRCAM neuronal cell adhesion molecule
NUPR1 nuclear protein, transcriptional regulator, 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PELI2 pellino E3 ubiquitin protein ligase family member 2
PHGDH phosphoglycerate dehydrogenase
PPL periplakin
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PRAF2 PRA1 domain family, member 2
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
R3HDM2 R3H domain containing 2
RGS16 regulator of G-protein signaling 16
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS27L ribosomal protein S27-like
RPS4Y1 ribosomal protein S4, Y-linked 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SESN1 sestrin 1
SFN stratifin
SLC16A6 solute carrier family 16, member 6
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC22A18 solute carrier family 22, member 18
SPTSSA serine palmitoyltransferase, small subunit A
SQLE squalene epoxidase
SQSTM1 sequestosome 1
SREBF2 sterol regulatory element binding transcription factor 2
STK26 serine/threonine protein kinase 26
SYT17 synaptotagmin XVII
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TPP1 tripeptidyl peptidase I
TXNRD1 thioredoxin reductase 1
VAT1 vesicle amine transport 1
VWA5A von Willebrand factor A domain containing 5A
WDTC1 WD and tetratricopeptide repeats 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
WLS wntless Wnt ligand secretion mediator
YPEL5 yippee-like 5 (Drosophila)
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
AKAP7 A kinase (PRKA) anchor protein 7
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APLP2 amyloid beta (A4) precursor-like protein 2
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CCNB1 cyclin B1
CD36 CD36 molecule (thrombospondin receptor)
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPN centromere protein N
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CYTL1 cytokine-like 1
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EBNA1BP2 EBNA1 binding protein 2
ECT2 epithelial cell transforming 2
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EREG epiregulin
FAM3C family with sequence similarity 3, member C
FKBP11 FK506 binding protein 11, 19 kDa
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPR171 G protein-coupled receptor 171
GRB14 growth factor receptor-bound protein 14
GRWD1 glutamate-rich WD repeat containing 1
HIST1H4C histone cluster 1, H4c
HK1 hexokinase 1
HMGB2 high mobility group box 2
HPRT1 hypoxanthine phosphoribosyltransferase 1
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IL13RA2 interleukin 13 receptor, alpha 2
IL1R2 interleukin 1 receptor, type II
KCTD12 potassium channel tetramerization domain containing 12
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT7 keratin 7, type II
LEPR leptin receptor
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MTERF3 mitochondrial transcription termination factor 3
NEFL neurofilament, light polypeptide
NELL2 NEL-like 2 (chicken)
NOL11 nucleolar protein 11
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON3 paraoxonase 3
POSTN periostin, osteoblast specific factor
PRKCH protein kinase C, eta
PRMT1 protein arginine methyltransferase 1
PSD3 pleckstrin and Sec7 domain containing 3
PTX3 pentraxin 3, long
RACGAP1 Rac GTPase activating protein 1
RBM47 RNA binding motif protein 47
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RGS4 regulator of G-protein signaling 4
RPS11 ribosomal protein S11
SDC2 syndecan 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMC4 structural maintenance of chromosomes 4
SNRPA1 small nuclear ribonucleoprotein polypeptide A'
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SORBS3 sorbin and SH3 domain containing 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRP72 signal recognition particle 72kDa
SRSF1 serine/arginine-rich splicing factor 1
STK17A serine/threonine kinase 17a
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TMPO thymopoietin
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIP13 thyroid hormone receptor interactor 13
UBE2C ubiquitin-conjugating enzyme E2C
UNG uracil-DNA glycosylase
WT1 Wilms tumor 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZNF22 zinc finger protein 22