BRD-K36740062_GSK-1070916_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

70 genes differentially expressed following the BRD-K36740062_GSK-1070916_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATF3 activating transcription factor 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BASP1 brain abundant, membrane attached signal protein 1
BTG2 BTG family, member 2
CCND2 cyclin D2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES2 carboxylesterase 2
DDB2 damage-specific DNA binding protein 2, 48kDa
EGR1 early growth response 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FDXR ferredoxin reductase
GAS6 growth arrest-specific 6
GDF15 growth differentiation factor 15
GREM1 gremlin 1, DAN family BMP antagonist
H2BFS H2B histone family, member S (pseudogene)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BK histone cluster 1, H2bk
KLK11 kallikrein-related peptidase 11
LGALS1 lectin, galactoside-binding, soluble, 1
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NQO1 NAD(P)H dehydrogenase, quinone 1
ODC1 ornithine decarboxylase 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
RPS27L ribosomal protein S27-like
SESN1 sestrin 1
SQSTM1 sequestosome 1
TIGAR TP53 induced glycolysis regulatory phosphatase
TOB1 transducer of ERBB2, 1
TRIM22 tripartite motif containing 22
WDTC1 WD and tetratricopeptide repeats 1
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
BACE2 beta-site APP-cleaving enzyme 2
BRCA1 breast cancer 1, early onset
C10ORF10 chromosome 10 open reading frame 10
C3 complement component 3
CDC25A cell division cycle 25A
CXCL14 chemokine (C-X-C motif) ligand 14
EPHA3 EPH receptor A3
GLUL glutamate-ammonia ligase
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
JADE2 jade family PHD finger 2
KRT23 keratin 23, type I
LMO2 LIM domain only 2 (rhombotin-like 1)
LTF lactotransferrin
LYZ lysozyme
NES nestin
PRDX2 peroxiredoxin 2
PRKACB protein kinase, cAMP-dependent, catalytic, beta
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SORBS3 sorbin and SH3 domain containing 3
TM4SF1 transmembrane 4 L six family member 1
TMEM45A transmembrane protein 45A
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPM1 tropomyosin 1 (alpha)
TSPAN13 tetraspanin 13