BRD-K36740062_GSK-1070916_A375_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

65 genes differentially expressed following the BRD-K36740062_GSK-1070916_A375_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
APOD apolipoprotein D
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ATF3 activating transcription factor 3
BASP1 brain abundant, membrane attached signal protein 1
BAX BCL2-associated X protein
CAV1 caveolin 1, caveolae protein, 22kDa
CCNG1 cyclin G1
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL4A5 collagen, type IV, alpha 5
CXCL13 chemokine (C-X-C motif) ligand 13
DDB2 damage-specific DNA binding protein 2, 48kDa
DUSP3 dual specificity phosphatase 3
FAS Fas cell surface death receptor
FBLN1 fibulin 1
GADD45A growth arrest and DNA-damage-inducible, alpha
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
IGF1R insulin-like growth factor 1 receptor
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
METTL7A methyltransferase like 7A
MVP major vault protein
PDLIM1 PDZ and LIM domain 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RPS27L ribosomal protein S27-like
SCG5 secretogranin V
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCUBE2 signal peptide, CUB domain, EGF-like 2
SESN1 sestrin 1
SRPX sushi-repeat containing protein, X-linked
TIGAR TP53 induced glycolysis regulatory phosphatase
TRIM22 tripartite motif containing 22
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
C10ORF10 chromosome 10 open reading frame 10
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CLPTM1 cleft lip and palate associated transmembrane protein 1
CXCL5 chemokine (C-X-C motif) ligand 5
H1F0 H1 histone family, member 0
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HOXC6 homeobox C6
MCM6 minichromosome maintenance complex component 6
MGP matrix Gla protein
MYLK myosin light chain kinase
NME4 NME/NM23 nucleoside diphosphate kinase 4
OPN3 opsin 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
RFC2 replication factor C (activator 1) 2, 40kDa
RGS5 regulator of G-protein signaling 5
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC6A14 solute carrier family 6 (amino acid transporter), member 14