BRD-K36737713_AG 957_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-K36737713_AG 957_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABHD4 abhydrolase domain containing 4
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANPEP alanyl (membrane) aminopeptidase
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
BMP6 bone morphogenetic protein 6
CAPN6 calpain 6
CARS cysteinyl-tRNA synthetase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC4 chloride intracellular channel 4
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EIF5 eukaryotic translation initiation factor 5
FAM134B family with sequence similarity 134, member B
FGFR1 fibroblast growth factor receptor 1
GAB2 GRB2-associated binding protein 2
GCLM glutamate-cysteine ligase, modifier subunit
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFRD1 interferon-related developmental regulator 1
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
INSIG1 insulin induced gene 1
LMO4 LIM domain only 4
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MCL1 myeloid cell leukemia 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MED1 mediator complex subunit 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NEFM neurofilament, medium polypeptide
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NNMT nicotinamide N-methyltransferase
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NRCAM neuronal cell adhesion molecule
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PELI1 pellino E3 ubiquitin protein ligase 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIR pirin (iron-binding nuclear protein)
PLIN2 perilipin 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PROM1 prominin 1
PSAT1 phosphoserine aminotransferase 1
RBM6 RNA binding motif protein 6
RGS1 regulator of G-protein signaling 1
RHOB ras homolog family member B
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM2 transmembrane protein 2
TSC22D3 TSC22 domain family, member 3
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
UGDH UDP-glucose 6-dehydrogenase
VCAM1 vascular cell adhesion molecule 1
XBP1 X-box binding protein 1
ZFAND5 zinc finger, AN1-type domain 5
ZNF638 zinc finger protein 638

decreased expression

Symbol Name
ACPP acid phosphatase, prostate
ACTG2 actin, gamma 2, smooth muscle, enteric
ADD3 adducin 3 (gamma)
AIM1 absent in melanoma 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARHGAP6 Rho GTPase activating protein 6
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
B3GNT1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL5 chemokine (C-C motif) ligand 5
CKB creatine kinase, brain
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
F3 coagulation factor III (thromboplastin, tissue factor)
GPRC5B G protein-coupled receptor, class C, group 5, member B
HOXA10 homeobox A10
KLK2 kallikrein-related peptidase 2
KLK3 kallikrein-related peptidase 3
KRT15 keratin 15, type I
LDHB lactate dehydrogenase B
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MACF1 microtubule-actin crosslinking factor 1
MATN2 matrilin 2
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NKG7 natural killer cell granule protein 7
NPDC1 neural proliferation, differentiation and control, 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NREP neuronal regeneration related protein
NT5DC2 5'-nucleotidase domain containing 2
NUP93 nucleoporin 93kDa
OBSL1 obscurin-like 1
OXTR oxytocin receptor
PEG10 paternally expressed 10
RAB40B RAB40B, member RAS oncogene family
RAB4A RAB4A, member RAS oncogene family
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RPL31 ribosomal protein L31
SCGB2A1 secretoglobin, family 2A, member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPDEF SAM pointed domain containing ETS transcription factor
SRPX sushi-repeat containing protein, X-linked
STEAP1 six transmembrane epithelial antigen of the prostate 1
TACSTD2 tumor-associated calcium signal transducer 2
TARBP1 TAR (HIV-1) RNA binding protein 1
TARP TCR gamma alternate reading frame protein
TFPI2 tissue factor pathway inhibitor 2
TSPAN5 tetraspanin 5