BRD-K36737713_AG 957_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

98 genes differentially expressed following the BRD-K36737713_AG 957_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANPEP alanyl (membrane) aminopeptidase
ATF4 activating transcription factor 4
CSTA cystatin A (stefin A)
DDIT4 DNA-damage-inducible transcript 4
EZR ezrin
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
IDS iduronate 2-sulfatase
KLF4 Kruppel-like factor 4 (gut)
LTF lactotransferrin
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MXI1 MAX interactor 1, dimerization protein
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
PLA2G16 phospholipase A2, group XVI
PRNP prion protein
QPCT glutaminyl-peptide cyclotransferase
RGCC regulator of cell cycle
RHCG Rh family, C glycoprotein
RND3 Rho family GTPase 3
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SFN stratifin
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPRR3 small proline-rich protein 3
SQSTM1 sequestosome 1
SRGN serglycin
TRIM16 tripartite motif containing 16
TUBB2A tubulin, beta 2A class IIa
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
XIST X inactive specific transcript (non-protein coding)
ZFAND5 zinc finger, AN1-type domain 5

decreased expression

Symbol Name
ACAA1 acetyl-CoA acyltransferase 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
BDH1 3-hydroxybutyrate dehydrogenase, type 1
CALU calumenin
CCND1 cyclin D1
CKB creatine kinase, brain
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DCK deoxycytidine kinase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLC1 DLC1 Rho GTPase activating protein
EFNB2 ephrin-B2
ERBB2 erb-b2 receptor tyrosine kinase 2
EXOSC4 exosome component 4
FABP1 fatty acid binding protein 1, liver
FHL1 four and a half LIM domains 1
GFRA1 GDNF family receptor alpha 1
GPX3 glutathione peroxidase 3
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP1 insulin-like growth factor binding protein 1
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KIF14 kinesin family member 14
MARCKSL1 MARCKS-like 1
MXRA5 matrix-remodelling associated 5
NFIB nuclear factor I/B
NMU neuromedin U
PCP4 Purkinje cell protein 4
PRKCH protein kinase C, eta
PSD3 pleckstrin and Sec7 domain containing 3
PTGIS prostaglandin I2 (prostacyclin) synthase
PXMP2 peroxisomal membrane protein 2, 22kDa
RPS11 ribosomal protein S11
SCG5 secretogranin V
SORBS1 sorbin and SH3 domain containing 1
SORBS3 sorbin and SH3 domain containing 3
SORD sorbitol dehydrogenase
SRPX sushi-repeat containing protein, X-linked
TBC1D16 TBC1 domain family, member 16
TBC1D31 TBC1 domain family, member 31
TUSC3 tumor suppressor candidate 3
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)