BRD-K36737713_AG 957_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

156 genes differentially expressed following the BRD-K36737713_AG 957_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABHD4 abhydrolase domain containing 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALAS1 5'-aminolevulinate synthase 1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANPEP alanyl (membrane) aminopeptidase
BAG3 BCL2-associated athanogene 3
BLVRB biliverdin reductase B
CBR1 carbonyl reductase 1
CBR3 carbonyl reductase 3
CCR1 chemokine (C-C motif) receptor 1
CD9 CD9 molecule
CES1 carboxylesterase 1
CST1 cystatin SN
CTSL cathepsin L
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DST dystonin
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FABP4 fatty acid binding protein 4, adipocyte
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GALC galactosylceramidase
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GLA galactosidase, alpha
GLRX glutaredoxin (thioltransferase)
GPC1 glypican 1
GPX2 glutathione peroxidase 2
GUSBP11 glucuronidase, beta pseudogene 11
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
IKZF1 IKAROS family zinc finger 1 (Ikaros)
JMJD6 jumonji domain containing 6
KYNU kynureninase
LTF lactotransferrin
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP3 matrix metallopeptidase 3
NAMPT nicotinamide phosphoribosyltransferase
NEBL nebulette
NEFL neurofilament, light polypeptide
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
PGD phosphogluconate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIR pirin (iron-binding nuclear protein)
PPAP2B phosphatidic acid phosphatase type 2B
PRNP prion protein
RAB9A RAB9A, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RGCC regulator of cell cycle
SAT1 spermidine/spermine N1-acetyltransferase 1
SFN stratifin
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
SQSTM1 sequestosome 1
SRGN serglycin
STX1A syntaxin 1A (brain)
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
UPP1 uridine phosphorylase 1

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALCAM activated leukocyte cell adhesion molecule
APOA1 apolipoprotein A-I
ASCL1 achaete-scute family bHLH transcription factor 1
BICC1 BicC family RNA binding protein 1
C3 complement component 3
CALD1 caldesmon 1
CFB complement factor B
CLDN1 claudin 1
CLDN18 claudin 18
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CRIP1 cysteine-rich protein 1 (intestinal)
CRIP2 cysteine-rich protein 2
CXCL2 chemokine (C-X-C motif) ligand 2
DDIT4 DNA-damage-inducible transcript 4
DHFR dihydrofolate reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DMD dystrophin
DPYSL2 dihydropyrimidinase-like 2
DTX4 deltex 4, E3 ubiquitin ligase
EIF5A eukaryotic translation initiation factor 5A
ERGIC2 ERGIC and golgi 2
FGFR3 fibroblast growth factor receptor 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GBP1 guanylate binding protein 1, interferon-inducible
GLS glutaminase
H1F0 H1 histone family, member 0
H1FX H1 histone family, member X
IFITM1 interferon induced transmembrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOC100505650 uncharacterized LOC100505650
LOX lysyl oxidase
LY6E lymphocyte antigen 6 complex, locus E
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MCM4 minichromosome maintenance complex component 4
NNMT nicotinamide N-methyltransferase
NREP neuronal regeneration related protein
NTM neurotrimin
PEG10 paternally expressed 10
PHGDH phosphoglycerate dehydrogenase
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PNMA2 paraneoplastic Ma antigen 2
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PRKCZ protein kinase C, zeta
PTGIS prostaglandin I2 (prostacyclin) synthase
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RBP1 retinol binding protein 1, cellular
SCEL sciellin
SCGB2A1 secretoglobin, family 2A, member 1
SOX11 SRY (sex determining region Y)-box 11
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
SPTBN1 spectrin, beta, non-erythrocytic 1
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TLE4 transducin-like enhancer of split 4
TMEM45A transmembrane protein 45A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS3 tensin 3
TPM1 tropomyosin 1 (alpha)
TRIM22 tripartite motif containing 22
TSC22D3 TSC22 domain family, member 3
TYMS thymidylate synthetase
TYRP1 tyrosinase-related protein 1
VCAN versican