BRD-K36737713_AG 957_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

236 genes differentially expressed following the BRD-K36737713_AG 957_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
AMDHD2 amidohydrolase domain containing 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AVPI1 arginine vasopressin-induced 1
BAG3 BCL2-associated athanogene 3
BTG1 B-cell translocation gene 1, anti-proliferative
CA2 carbonic anhydrase II
CALCOCO2 calcium binding and coiled-coil domain 2
CCNG2 cyclin G2
CCPG1 cell cycle progression 1
CD163 CD163 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CGRRF1 cell growth regulator with ring finger domain 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHMP1B charged multivesicular body protein 1B
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CREM cAMP responsive element modulator
CTH cystathionine gamma-lyase
CYB5R1 cytochrome b5 reductase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
DYSF dysferlin
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM117A family with sequence similarity 117, member A
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FOXO4 forkhead box O4
GAGE3 G antigen 3
GARS glycyl-tRNA synthetase
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GLA galactosidase, alpha
GRN granulin
GSN gelsolin
HBB hemoglobin, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST3H2A histone cluster 3, H2a
HK1 hexokinase 1
HK2 hexokinase 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IFRD1 interferon-related developmental regulator 1
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
ISG20 interferon stimulated exonuclease gene 20kDa
JUND jun D proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KLF4 Kruppel-like factor 4 (gut)
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARS methionyl-tRNA synthetase
MCOLN1 mucolipin 1
MKNK2 MAP kinase interacting serine/threonine kinase 2
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC5B mucin 5B, oligomeric mucus/gel-forming
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NPC1 Niemann-Pick disease, type C1
NQO2 NAD(P)H dehydrogenase, quinone 2
NRBF2 nuclear receptor binding factor 2
NUPR1 nuclear protein, transcriptional regulator, 1
ODC1 ornithine decarboxylase 1
OSBPL10 oxysterol binding protein-like 10
PAX8 paired box 8
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PELI1 pellino E3 ubiquitin protein ligase 1
PLA2G16 phospholipase A2, group XVI
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POPDC3 popeye domain containing 3
POR P450 (cytochrome) oxidoreductase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RB1CC1 RB1-inducible coiled-coil 1
RBP4 retinol binding protein 4, plasma
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RIOK3 RIO kinase 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRAGD Ras-related GTP binding D
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCYL3 SCY1-like 3 (S. cerevisiae)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC16A6 solute carrier family 16, member 6
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SQSTM1 sequestosome 1
STX3 syntaxin 3
STXBP1 syntaxin binding protein 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TERF2IP telomeric repeat binding factor 2, interacting protein
TPP1 tripeptidyl peptidase I
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
TXNRD1 thioredoxin reductase 1
UGDH UDP-glucose 6-dehydrogenase
UPP1 uridine phosphorylase 1
WARS tryptophanyl-tRNA synthetase
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
XPOT exportin, tRNA
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ABR active BCR-related
ADD3 adducin 3 (gamma)
ALCAM activated leukocyte cell adhesion molecule
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BHLHE40 basic helix-loop-helix family, member e40
C1ORF116 chromosome 1 open reading frame 116
C3 complement component 3
C8ORF4 chromosome 8 open reading frame 4
CALD1 caldesmon 1
CASP7 caspase 7, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CD59 CD59 molecule, complement regulatory protein
CTPS1 CTP synthase 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL5 chemokine (C-X-C motif) ligand 5
CYTH1 cytohesin 1
DDHD2 DDHD domain containing 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
EDN1 endothelin 1
EGF epidermal growth factor
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ERAP2 endoplasmic reticulum aminopeptidase 2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FGFR3 fibroblast growth factor receptor 3
GBP1 guanylate binding protein 1, interferon-inducible
GLIPR1 GLI pathogenesis-related 1
GRAMD1C GRAM domain containing 1C
GREM1 gremlin 1, DAN family BMP antagonist
GRWD1 glutamate-rich WD repeat containing 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HOXA10 homeobox A10
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI16 interferon, gamma-inducible protein 16
IGFBP3 insulin-like growth factor binding protein 3
IL7R interleukin 7 receptor
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
JUN jun proto-oncogene
KLHL9 kelch-like family member 9
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAGED1 melanoma antigen family D1
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM3 minichromosome maintenance complex component 3
MMP7 matrix metallopeptidase 7
MSH6 mutS homolog 6
NBN nibrin
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NREP neuronal regeneration related protein
NUAK1 NUAK family, SNF1-like kinase, 1
NUSAP1 nucleolar and spindle associated protein 1
OXTR oxytocin receptor
P3H2 prolyl 3-hydroxylase 2
PDLIM5 PDZ and LIM domain 5
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PNN pinin, desmosome associated protein
PPIF peptidylprolyl isomerase F
PRKCH protein kinase C, eta
PRSS23 protease, serine, 23
PSCA prostate stem cell antigen
PSD3 pleckstrin and Sec7 domain containing 3
RHOBTB3 Rho-related BTB domain containing 3
RIN2 Ras and Rab interactor 2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SMAD1 SMAD family member 1
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SRSF1 serine/arginine-rich splicing factor 1
TARP TCR gamma alternate reading frame protein
TBC1D2B TBC1 domain family, member 2B
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNS1 tensin 1
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM4 tropomyosin 4
TRIM14 tripartite motif containing 14
TSPAN8 tetraspanin 8
UBE2C ubiquitin-conjugating enzyme E2C
UBE2E1 ubiquitin-conjugating enzyme E2E 1
USP1 ubiquitin specific peptidase 1
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF22 zinc finger protein 22