BRD-K36737713_AG 957_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

263 genes differentially expressed following the BRD-K36737713_AG 957_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADCY2 adenylate cyclase 2 (brain)
ADM adrenomedullin
AIM2 absent in melanoma 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALAS1 5'-aminolevulinate synthase 1
AMDHD2 amidohydrolase domain containing 2
ARMCX1 armadillo repeat containing, X-linked 1
ATF3 activating transcription factor 3
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
BAMBI BMP and activin membrane-bound inhibitor
BMP2 bone morphogenetic protein 2
BMP7 bone morphogenetic protein 7
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CADM1 cell adhesion molecule 1
CAMP cathelicidin antimicrobial peptide
CCND3 cyclin D3
CD163 CD163 molecule
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD52 CD52 molecule
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CLEC2B C-type lectin domain family 2, member B
CXCR4 chemokine (C-X-C motif) receptor 4
CYB5R1 cytochrome b5 reductase 1
DDIT3 DNA-damage-inducible transcript 3
DENND1B DENN/MADD domain containing 1B
DUSP6 dual specificity phosphatase 6
EZR ezrin
FABP4 fatty acid binding protein 4, adipocyte
FCGBP Fc fragment of IgG binding protein
FRZB frizzled-related protein
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GBAP1 glucosidase, beta, acid pseudogene 1
GDF15 growth differentiation factor 15
GLA galactosidase, alpha
GPM6B glycoprotein M6B
H2BFS H2B histone family, member S (pseudogene)
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
HK2 hexokinase 2
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
IL13RA2 interleukin 13 receptor, alpha 2
IL1R2 interleukin 1 receptor, type II
INSR insulin receptor
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLHL21 kelch-like family member 21
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
KYNU kynureninase
LAMP2 lysosomal-associated membrane protein 2
LAPTM5 lysosomal protein transmembrane 5
LTB lymphotoxin beta (TNF superfamily, member 3)
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MMP9 matrix metallopeptidase 9
MUC5B mucin 5B, oligomeric mucus/gel-forming
NELL2 NEL-like 2 (chicken)
NQO1 NAD(P)H dehydrogenase, quinone 1
NRCAM neuronal cell adhesion molecule
OAT ornithine aminotransferase
PEG3 paternally expressed 3
PI3 peptidase inhibitor 3, skin-derived
PLIN2 perilipin 2
PLXNC1 plexin C1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POPDC3 popeye domain containing 3
POU2AF1 POU class 2 associating factor 1
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A
PRRC2C proline-rich coiled-coil 2C
RBBP6 retinoblastoma binding protein 6
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SCPEP1 serine carboxypeptidase 1
SEPHS2 selenophosphate synthetase 2
SLC16A6 solute carrier family 16, member 6
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
STX3 syntaxin 3
THBD thrombomodulin
TMEM30B transmembrane protein 30B
TPD52 tumor protein D52
TXNRD1 thioredoxin reductase 1
USP47 ubiquitin specific peptidase 47
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VNN1 vanin 1
VNN2 vanin 2
WDR26 WD repeat domain 26
XIST X inactive specific transcript (non-protein coding)
ZNF117 zinc finger protein 117
ZNF232 zinc finger protein 232
ZNF274 zinc finger protein 274
ZNF423 zinc finger protein 423
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACSF2 acyl-CoA synthetase family member 2
ACSL5 acyl-CoA synthetase long-chain family member 5
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADD3 adducin 3 (gamma)
AKAP7 A kinase (PRKA) anchor protein 7
ALCAM activated leukocyte cell adhesion molecule
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
AURKA aurora kinase A
BST2 bone marrow stromal cell antigen 2
CALB1 calbindin 1, 28kDa
CALD1 caldesmon 1
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CAV2 caveolin 2
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CDC25C cell division cycle 25C
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
COL1A1 collagen, type I, alpha 1
COL5A1 collagen, type V, alpha 1
CRIP2 cysteine-rich protein 2
CST3 cystatin C
CXCL12 chemokine (C-X-C motif) ligand 12
CYB5A cytochrome b5 type A (microsomal)
DCXR dicarbonyl/L-xylulose reductase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
DEFB1 defensin, beta 1
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DMD dystrophin
ECI2 enoyl-CoA delta isomerase 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGF epidermal growth factor
ENO1 enolase 1, (alpha)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHB2 EPH receptor B2
EPN2 epsin 2
FADS2 fatty acid desaturase 2
FBN1 fibrillin 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GPATCH8 G patch domain containing 8
GPSM2 G-protein signaling modulator 2
H3F3B H3 histone, family 3B (H3.3B)
HACD2 3-hydroxyacyl-CoA dehydratase 2
HAUS4 HAUS augmin-like complex, subunit 4
HMGB3 high mobility group box 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
HOPX HOP homeobox
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IL6ST interleukin 6 signal transducer
INSIG1 insulin induced gene 1
ITGB1BP1 integrin beta 1 binding protein 1
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIF20A kinesin family member 20A
KRT7 keratin 7, type II
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LAPTM4B lysosomal protein transmembrane 4 beta
LDLR low density lipoprotein receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
MAP4 microtubule-associated protein 4
MDFIC MyoD family inhibitor domain containing
MEIS1 Meis homeobox 1
MGP matrix Gla protein
MYLK myosin light chain kinase
NEK2 NIMA-related kinase 2
NNT nicotinamide nucleotide transhydrogenase
NPR3 natriuretic peptide receptor 3
NREP neuronal regeneration related protein
NUP85 nucleoporin 85kDa
P3H2 prolyl 3-hydroxylase 2
PALLD palladin, cytoskeletal associated protein
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDGFC platelet derived growth factor C
PDLIM2 PDZ and LIM domain 2 (mystique)
PFKP phosphofructokinase, platelet
PGM1 phosphoglucomutase 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLK1 polo-like kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRSS23 protease, serine, 23
PTTG1 pituitary tumor-transforming 1
PXMP2 peroxisomal membrane protein 2, 22kDa
PYCR1 pyrroline-5-carboxylate reductase 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBPMS RNA binding protein with multiple splicing
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100A10 S100 calcium binding protein A10
S100A2 S100 calcium binding protein A2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCP2 sterol carrier protein 2
SEC23A Sec23 homolog A (S. cerevisiae)
SEPT11 septin 11
SEPT8 septin 8
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SH3YL1 SH3 and SYLF domain containing 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SORBS3 sorbin and SH3 domain containing 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPC25 SPC25, NDC80 kinetochore complex component
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STMN1 stathmin 1
SUMO2 small ubiquitin-like modifier 2
SYBU syntabulin (syntaxin-interacting)
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
THY1 Thy-1 cell surface antigen
TM4SF1 transmembrane 4 L six family member 1
TMEM47 transmembrane protein 47
TNC tenascin C
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TPX2 TPX2, microtubule-associated
TTC3 tetratricopeptide repeat domain 3
TUBB tubulin, beta class I
TUSC3 tumor suppressor candidate 3
UBE2C ubiquitin-conjugating enzyme E2C
VCAN versican
WDR61 WD repeat domain 61
WFDC2 WAP four-disulfide core domain 2
XYLT1 xylosyltransferase I
ZCCHC24 zinc finger, CCHC domain containing 24