BRD-K36363294_I-BET151_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

333 genes differentially expressed following the BRD-K36363294_I-BET151_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ALDOA aldolase A, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ASMTL acetylserotonin O-methyltransferase-like
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BAMBI BMP and activin membrane-bound inhibitor
BLNK B-cell linker
C14ORF132 chromosome 14 open reading frame 132
CA2 carbonic anhydrase II
CAV2 caveolin 2
CCDC85B coiled-coil domain containing 85B
CCDC92 coiled-coil domain containing 92
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CIRBP cold inducible RNA binding protein
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CORO1C coronin, actin binding protein, 1C
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CREG1 cellular repressor of E1A-stimulated genes 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CXCL13 chemokine (C-X-C motif) ligand 13
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAPK1 death-associated protein kinase 1
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
DST dystonin
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP14 dual specificity phosphatase 14
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
ENAH enabled homolog (Drosophila)
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
ESYT1 extended synaptotagmin-like protein 1
EZR ezrin
FADS3 fatty acid desaturase 3
FAM50A family with sequence similarity 50, member A
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
FTH1 ferritin, heavy polypeptide 1
GADD45B growth arrest and DNA-damage-inducible, beta
GDF15 growth differentiation factor 15
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GHR growth hormone receptor
GJA1 gap junction protein, alpha 1, 43kDa
GPX1 glutathione peroxidase 1
GREM1 gremlin 1, DAN family BMP antagonist
GRN granulin
GRWD1 glutamate-rich WD repeat containing 1
GSTM3 glutathione S-transferase mu 3 (brain)
H2BFS H2B histone family, member S (pseudogene)
HEPH hephaestin
HIP1R huntingtin interacting protein 1 related
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BF histone cluster 1, H2bf
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
INSR insulin receptor
JUND jun D proto-oncogene
KIAA0513 KIAA0513
KIAA1033 KIAA1033
KIF2C kinesin family member 2C
LONP2 lon peptidase 2, peroxisomal
LRP4 low density lipoprotein receptor-related protein 4
LRRC16A leucine rich repeat containing 16A
MACF1 microtubule-actin crosslinking factor 1
MAGEB2 melanoma antigen family B2
MALT1 MALT1 paracaspase
MARCKSL1 MARCKS-like 1
MEF2C myocyte enhancer factor 2C
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
MYO1B myosin IB
MYO6 myosin VI
NEBL nebulette
NPTX2 neuronal pentraxin II
NPY neuropeptide Y
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NXN nucleoredoxin
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2
PALLD palladin, cytoskeletal associated protein
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX3 pre-B-cell leukemia homeobox 3
PCDH9 protocadherin 9
PDLIM5 PDZ and LIM domain 5
PEG3 paternally expressed 3
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLCB4 phospholipase C, beta 4
PLK2 polo-like kinase 2
PNKP polynucleotide kinase 3'-phosphatase
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCZ protein kinase C, zeta
PROM1 prominin 1
PTPRD protein tyrosine phosphatase, receptor type, D
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
REEP1 receptor accessory protein 1
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC2 syndecan 2
SECISBP2L SECIS binding protein 2-like
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SF1 splicing factor 1
SIK1 salt-inducible kinase 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPATA2L spermatogenesis associated 2-like
SRSF11 serine/arginine-rich splicing factor 11
STAT1 signal transducer and activator of transcription 1, 91kDa
STX12 syntaxin 12
STXBP1 syntaxin binding protein 1
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
THBS1 thrombospondin 1
TM7SF2 transmembrane 7 superfamily member 2
TMSB15A thymosin beta 15a
TNNT1 troponin T type 1 (skeletal, slow)
TPD52L1 tumor protein D52-like 1
TSC22D2 TSC22 domain family, member 2
TUFT1 tuftelin 1
USP9X ubiquitin specific peptidase 9, X-linked
VCL vinculin
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZFP36 ZFP36 ring finger protein
ZNF131 zinc finger protein 131

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ADGRG1 adhesion G protein-coupled receptor G1
AIM1 absent in melanoma 1
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANPEP alanyl (membrane) aminopeptidase
ANXA1 annexin A1
AQP1 aquaporin 1 (Colton blood group)
AQP3 aquaporin 3 (Gill blood group)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
BPIFA1 BPI fold containing family A, member 1
C1ORF106 chromosome 1 open reading frame 106
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C3 complement component 3
CA12 carbonic anhydrase XII
CALML3 calmodulin-like 3
CCND2 cyclin D2
CDCA3 cell division cycle associated 3
CDK4 cyclin-dependent kinase 4
CFI complement factor I
CHEK1 checkpoint kinase 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC2B C-type lectin domain family 2, member B
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COPS7A COP9 signalosome subunit 7A
CRABP2 cellular retinoic acid binding protein 2
CSTA cystatin A (stefin A)
CXCL14 chemokine (C-X-C motif) ligand 14
DHRS3 dehydrogenase/reductase (SDR family) member 3
DPYD dihydropyrimidine dehydrogenase
DPYSL3 dihydropyrimidinase-like 3
EPCAM epithelial cell adhesion molecule
ESR1 estrogen receptor 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FGFBP1 fibroblast growth factor binding protein 1
FOXM1 forkhead box M1
FST follistatin
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GGCT gamma-glutamylcyclotransferase
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GLUL glutamate-ammonia ligase
GPR171 G protein-coupled receptor 171
GUSBP11 glucuronidase, beta pseudogene 11
GYPC glycophorin C (Gerbich blood group)
HIRA histone cell cycle regulator
HMGA2 high mobility group AT-hook 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOPX HOP homeobox
HOXB2 homeobox B2
HSPB1 heat shock 27kDa protein 1
ICAM3 intercellular adhesion molecule 3
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI16 interferon, gamma-inducible protein 16
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IGFBP6 insulin-like growth factor binding protein 6
IGFBP7 insulin-like growth factor binding protein 7
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL1 immunoglobulin lambda-like polypeptide 1
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
ITM2A integral membrane protein 2A
JADE2 jade family PHD finger 2
JCHAIN joining chain of multimeric IgA and IgM
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT19 keratin 19, type I
KRT5 keratin 5, type II
LAMA3 laminin, alpha 3
LEF1 lymphoid enhancer-binding factor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMNB1 lamin B1
LMO4 LIM domain only 4
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
LPAR1 lysophosphatidic acid receptor 1
LRRC17 leucine rich repeat containing 17
MAPK13 mitogen-activated protein kinase 13
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MDK midkine (neurite growth-promoting factor 2)
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MPZL2 myelin protein zero-like 2
MRC2 mannose receptor, C type 2
NDC80 NDC80 kinetochore complex component
NES nestin
NET1 neuroepithelial cell transforming 1
NMI N-myc (and STAT) interactor
NMU neuromedin U
NREP neuronal regeneration related protein
NRP1 neuropilin 1
NT5E 5'-nucleotidase, ecto (CD73)
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
PCOLCE procollagen C-endopeptidase enhancer
PDAP1 PDGFA associated protein 1
PDGFD platelet derived growth factor D
PDGFRL platelet-derived growth factor receptor-like
PDIA3 protein disulfide isomerase family A, member 3
PDLIM1 PDZ and LIM domain 1
PIP prolactin-induced protein
PLBD1 phospholipase B domain containing 1
PLTP phospholipid transfer protein
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
PYCR1 pyrroline-5-carboxylate reductase 1
RAB25 RAB25, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
RAD51AP1 RAD51 associated protein 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
S100A2 S100 calcium binding protein A2
S100A4 S100 calcium binding protein A4
S100A6 S100 calcium binding protein A6
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SMAGP small cell adhesion glycoprotein
SORBS3 sorbin and SH3 domain containing 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
SPINK5 serine peptidase inhibitor, Kazal type 5
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TAGLN2 transgelin 2
TF transferrin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS2 thrombospondin 2
TM4SF1 transmembrane 4 L six family member 1
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMEM97 transmembrane protein 97
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TOP2A topoisomerase (DNA) II alpha 170kDa
TPBG trophoblast glycoprotein
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRBC1 T cell receptor beta constant 1
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIM14 tripartite motif containing 14
TYRP1 tyrosinase-related protein 1
VCAN versican
VGLL4 vestigial-like family member 4
ZFP36L1 ZFP36 ring finger protein-like 1
ZHX2 zinc fingers and homeoboxes 2
ZNF22 zinc finger protein 22