BRD-K36363294_I-BET151_HT29_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

128 genes differentially expressed following the BRD-K36363294_I-BET151_HT29_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ASMTL acetylserotonin O-methyltransferase-like
CCDC85B coiled-coil domain containing 85B
CCDC92 coiled-coil domain containing 92
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CPNE3 copine III
CTSB cathepsin B
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP10 dual specificity phosphatase 10
EDNRB endothelin receptor type B
EFNB2 ephrin-B2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3
FAM50A family with sequence similarity 50, member A
FUCA1 fucosidase, alpha-L- 1, tissue
FZD7 frizzled class receptor 7
GOLGA8H golgin A8 family, member H
GPNMB glycoprotein (transmembrane) nmb
GPX1 glutathione peroxidase 1
GRN granulin
GSN gelsolin
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HOOK2 hook microtubule-tethering protein 2
HSPA1A heat shock 70kDa protein 1A
INSIG1 insulin induced gene 1
IQGAP1 IQ motif containing GTPase activating protein 1
JAG1 jagged 1
KAZN kazrin, periplakin interacting protein
KDM5D lysine (K)-specific demethylase 5D
KRT5 keratin 5, type II
LGALS1 lectin, galactoside-binding, soluble, 1
LGMN legumain
MACF1 microtubule-actin crosslinking factor 1
MAST2 microtubule associated serine/threonine kinase 2
MTSS1 metastasis suppressor 1
MVP major vault protein
MXRA7 matrix-remodelling associated 7
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
MYLK myosin light chain kinase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NOTCH2NL notch 2 N-terminal like
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PALLD palladin, cytoskeletal associated protein
PNKP polynucleotide kinase 3'-phosphatase
RPS4Y1 ribosomal protein S4, Y-linked 1
SCAND1 SCAN domain containing 1
SCPEP1 serine carboxypeptidase 1
SIRT3 sirtuin 3
SLC16A6 solute carrier family 16, member 6
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SQSTM1 sequestosome 1
STXBP1 syntaxin binding protein 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TANK TRAF family member-associated NFKB activator
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM7SF2 transmembrane 7 superfamily member 2
TMEM2 transmembrane protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPP1 tripeptidyl peptidase I
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
ADGRG1 adhesion G protein-coupled receptor G1
ANXA1 annexin A1
AQP3 aquaporin 3 (Gill blood group)
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BCHE butyrylcholinesterase
CALB1 calbindin 1, 28kDa
CCDC86 coiled-coil domain containing 86
CRYZ crystallin, zeta (quinone reductase)
DPH2 DPH2 homolog (S. cerevisiae)
DUSP2 dual specificity phosphatase 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FSCN1 fascin actin-bundling protein 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IARS isoleucyl-tRNA synthetase
IFRD2 interferon-related developmental regulator 2
IGF1 insulin-like growth factor 1 (somatomedin C)
IPO5 importin 5
JADE2 jade family PHD finger 2
MAL mal, T-cell differentiation protein
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MRPL3 mitochondrial ribosomal protein L3
MSH6 mutS homolog 6
MSLN mesothelin
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
NMI N-myc (and STAT) interactor
NOP16 NOP16 nucleolar protein
NR1H2 nuclear receptor subfamily 1, group H, member 2
P3H2 prolyl 3-hydroxylase 2
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PDLIM1 PDZ and LIM domain 1
PFKP phosphofructokinase, platelet
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLBD1 phospholipase B domain containing 1
PXMP2 peroxisomal membrane protein 2, 22kDa
PYCR1 pyrroline-5-carboxylate reductase 1
RPP40 ribonuclease P/MRP 40kDa subunit
SET SET nuclear proto-oncogene
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC35F2 solute carrier family 35, member F2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPRY2 sprouty homolog 2 (Drosophila)
SRM spermidine synthase
SRP72 signal recognition particle 72kDa
STEAP3 STEAP family member 3, metalloreductase
TAGLN2 transgelin 2
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TRBC1 T cell receptor beta constant 1
TRIM14 tripartite motif containing 14
TSPAN8 tetraspanin 8
XIST X inactive specific transcript (non-protein coding)