BRD-K36363294_I-BET151_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

186 genes differentially expressed following the BRD-K36363294_I-BET151_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABAT 4-aminobutyrate aminotransferase
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDOA aldolase A, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ASMTL acetylserotonin O-methyltransferase-like
BEX1 brain expressed, X-linked 1
C14ORF132 chromosome 14 open reading frame 132
CCNG2 cyclin G2
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CELF2 CUGBP, Elav-like family member 2
CIRBP cold inducible RNA binding protein
CLGN calmegin
CPNE3 copine III
CRIP2 cysteine-rich protein 2
CTSA cathepsin A
CXADR coxsackie virus and adenovirus receptor
CYFIP2 cytoplasmic FMR1 interacting protein 2
DLD dihydrolipoamide dehydrogenase
DUSP1 dual specificity phosphatase 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
GABARAPL2 GABA(A) receptor-associated protein-like 2
GALC galactosylceramidase
GDE1 glycerophosphodiester phosphodiesterase 1
GPX2 glutathione peroxidase 2
GSN gelsolin
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AG histone cluster 1, H2ag
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HK1 hexokinase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
INSM1 insulinoma-associated 1
IQGAP1 IQ motif containing GTPase activating protein 1
LAMP2 lysosomal-associated membrane protein 2
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
LXN latexin
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MYO6 myosin VI
NEBL nebulette
NQO1 NAD(P)H dehydrogenase, quinone 1
NRCAM neuronal cell adhesion molecule
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1
OSBPL10 oxysterol binding protein-like 10
OSTM1 osteopetrosis associated transmembrane protein 1
PBX3 pre-B-cell leukemia homeobox 3
PCCB propionyl CoA carboxylase, beta polypeptide
PCDH9 protocadherin 9
PCM1 pericentriolar material 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PRAF2 PRA1 domain family, member 2
RHOA ras homolog family member A
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SQSTM1 sequestosome 1
STOM stomatin
STXBP1 syntaxin binding protein 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TMEM50A transmembrane protein 50A
TMSB15A thymosin beta 15a
TPD52L1 tumor protein D52-like 1
TPP1 tripeptidyl peptidase I
TUBA1A tubulin, alpha 1a
TXNRD1 thioredoxin reductase 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
USP6NL USP6 N-terminal like
VAT1 vesicle amine transport 1

decreased expression

Symbol Name
AEBP1 AE binding protein 1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AQP3 aquaporin 3 (Gill blood group)
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
C1ORF106 chromosome 1 open reading frame 106
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C3 complement component 3
C7 complement component 7
CCNA2 cyclin A2
CCNB2 cyclin B2
CDK1 cyclin-dependent kinase 1
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL6A2 collagen, type VI, alpha 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DCN decorin
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EVI2A ecotropic viral integration site 2A
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FAS Fas cell surface death receptor
FBLN1 fibulin 1
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FHL2 four and a half LIM domains 2
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
FOXF2 forkhead box F2
G0S2 G0/G1 switch 2
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GBP2 guanylate binding protein 2, interferon-inducible
GLUL glutamate-ammonia ligase
HMGB1 high mobility group box 1
HOPX HOP homeobox
IFI16 interferon, gamma-inducible protein 16
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IPO13 importin 13
IPO5 importin 5
KRT17 keratin 17, type I
LEFTY1 left-right determination factor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOX lysyl oxidase
LPAR1 lysophosphatidic acid receptor 1
LTF lactotransferrin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MCM4 minichromosome maintenance complex component 4
MDK midkine (neurite growth-promoting factor 2)
MFAP4 microfibrillar-associated protein 4
MT1M metallothionein 1M
MYC v-myc avian myelocytomatosis viral oncogene homolog
NMI N-myc (and STAT) interactor
NR1H2 nuclear receptor subfamily 1, group H, member 2
P3H2 prolyl 3-hydroxylase 2
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCOLCE procollagen C-endopeptidase enhancer
PDE4B phosphodiesterase 4B, cAMP-specific
PLAUR plasminogen activator, urokinase receptor
PLK1 polo-like kinase 1
PLTP phospholipid transfer protein
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PYCR1 pyrroline-5-carboxylate reductase 1
RAB25 RAB25, member RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS2 regulator of G-protein signaling 2
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLPI secretory leukocyte peptidase inhibitor
SORBS3 sorbin and SH3 domain containing 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
SPRY2 sprouty homolog 2 (Drosophila)
SRSF6 serine/arginine-rich splicing factor 6
STEAP1 six transmembrane epithelial antigen of the prostate 1
STEAP3 STEAP family member 3, metalloreductase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI2 tissue factor pathway inhibitor 2
THBS4 thrombospondin 4
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM4 tropomyosin 4
TRBC1 T cell receptor beta constant 1
TSPAN8 tetraspanin 8
USP1 ubiquitin specific peptidase 1
VCAN versican
VSNL1 visinin-like 1
WNT5A wingless-type MMTV integration site family, member 5A
ZFP36L1 ZFP36 ring finger protein-like 1
ZWINT ZW10 interacting kinetochore protein