BRD-K36363294_I-BET151_A549_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

260 genes differentially expressed following the BRD-K36363294_I-BET151_A549_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AK1 adenylate kinase 1
ARG2 arginase 2
BLNK B-cell linker
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCDC85B coiled-coil domain containing 85B
CCDC92 coiled-coil domain containing 92
CCND1 cyclin D1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEMIP cell migration inducing protein, hyaluronan binding
CIRBP cold inducible RNA binding protein
CLIC3 chloride intracellular channel 3
CREG1 cellular repressor of E1A-stimulated genes 1
CTH cystathionine gamma-lyase
CXADR coxsackie virus and adenovirus receptor
CXCL13 chemokine (C-X-C motif) ligand 13
DAAM1 dishevelled associated activator of morphogenesis 1
DCXR dicarbonyl/L-xylulose reductase
DST dystonin
DUOX2 dual oxidase 2
DUSP14 dual specificity phosphatase 14
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3
EZR ezrin
FAM46A family with sequence similarity 46, member A
FZD7 frizzled class receptor 7
GPNMB glycoprotein (transmembrane) nmb
GSTM3 glutathione S-transferase mu 3 (brain)
H2BFS H2B histone family, member S (pseudogene)
HEBP1 heme binding protein 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HIST3H2A histone cluster 3, H2a
HK1 hexokinase 1
HK2 hexokinase 2
HSPA4L heat shock 70kDa protein 4-like
IGHM immunoglobulin heavy constant mu
IL13RA2 interleukin 13 receptor, alpha 2
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ITGA6 integrin, alpha 6
KDM1A lysine (K)-specific demethylase 1A
KRT5 keratin 5, type II
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MMP12 matrix metallopeptidase 12
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
MYLIP myosin regulatory light chain interacting protein
MYO6 myosin VI
NDRG1 N-myc downstream regulated 1
NEFH neurofilament, heavy polypeptide
NELL2 NEL-like 2 (chicken)
NPC2 Niemann-Pick disease, type C2
NXN nucleoredoxin
ODC1 ornithine decarboxylase 1
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PCYOX1 prenylcysteine oxidase 1
PLS3 plastin 3
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PRAF2 PRA1 domain family, member 2
RAB4A RAB4A, member RAS oncogene family
RCAN1 regulator of calcineurin 1
RLF rearranged L-myc fusion
RSRP1 arginine/serine-rich protein 1
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SCAND1 SCAN domain containing 1
SCGB2A2 secretoglobin, family 2A, member 2
SCPEP1 serine carboxypeptidase 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
STXBP1 syntaxin binding protein 1
SUN1 Sad1 and UNC84 domain containing 1
TFRC transferrin receptor
TIAM1 T-cell lymphoma invasion and metastasis 1
TOB1 transducer of ERBB2, 1
TPD52L1 tumor protein D52-like 1
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
ZCCHC14 zinc finger, CCHC domain containing 14

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADGRG1 adhesion G protein-coupled receptor G1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANXA1 annexin A1
AQP3 aquaporin 3 (Gill blood group)
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
ARL4C ADP-ribosylation factor-like 4C
ARMCX6 armadillo repeat containing, X-linked 6
ATF1 activating transcription factor 1
AXL AXL receptor tyrosine kinase
BAD BCL2-associated agonist of cell death
BCHE butyrylcholinesterase
BICC1 BicC family RNA binding protein 1
C1ORF106 chromosome 1 open reading frame 106
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C5 complement component 5
C8ORF4 chromosome 8 open reading frame 4
CA12 carbonic anhydrase XII
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL2 chemokine (C-C motif) ligand 2
CD99 CD99 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CFLAR CASP8 and FADD-like apoptosis regulator
CLDN10 claudin 10
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CP ceruloplasmin (ferroxidase)
CPB1 carboxypeptidase B1 (tissue)
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRYZ crystallin, zeta (quinone reductase)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL5 chemokine (C-X-C motif) ligand 5
DCTPP1 dCTP pyrophosphatase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DOK5 docking protein 5
EDN1 endothelin 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EMP3 epithelial membrane protein 3
EVI2A ecotropic viral integration site 2A
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM129A family with sequence similarity 129, member A
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FHL2 four and a half LIM domains 2
FLOT1 flotillin 1
FRZB frizzled-related protein
FXYD2 FXYD domain containing ion transport regulator 2
FXYD5 FXYD domain containing ion transport regulator 5
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GDF15 growth differentiation factor 15
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLRX glutaredoxin (thioltransferase)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GRB14 growth factor receptor-bound protein 14
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HBB hemoglobin, beta
HDGFRP3 hepatoma-derived growth factor, related protein 3
HMGA2 high mobility group AT-hook 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HOXA5 homeobox A5
HOXB2 homeobox B2
HOXB7 homeobox B7
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ICAM2 intercellular adhesion molecule 2
IFI16 interferon, gamma-inducible protein 16
IFRD2 interferon-related developmental regulator 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
ITM2A integral membrane protein 2A
JADE2 jade family PHD finger 2
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
LOC100505650 uncharacterized LOC100505650
LPGAT1 lysophosphatidylglycerol acyltransferase 1
LRRC41 leucine rich repeat containing 41
LXN latexin
LY6E lymphocyte antigen 6 complex, locus E
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MDK midkine (neurite growth-promoting factor 2)
MGLL monoglyceride lipase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MLPH melanophilin
MT1F metallothionein 1F
MUC16 mucin 16, cell surface associated
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NGRN neugrin, neurite outgrowth associated
NME4 NME/NM23 nucleoside diphosphate kinase 4
NMI N-myc (and STAT) interactor
NNMT nicotinamide N-methyltransferase
NOVA1 neuro-oncological ventral antigen 1
NPAS2 neuronal PAS domain protein 2
NPTX1 neuronal pentraxin I
NR0B1 nuclear receptor subfamily 0, group B, member 1
NRCAM neuronal cell adhesion molecule
NRP1 neuropilin 1
NTS neurotensin
NUAK1 NUAK family, SNF1-like kinase, 1
OLFML3 olfactomedin-like 3
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PAIP1 poly(A) binding protein interacting protein 1
PDE4B phosphodiesterase 4B, cAMP-specific
PDLIM2 PDZ and LIM domain 2 (mystique)
PDZK1 PDZ domain containing 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
PPARG peroxisome proliferator-activated receptor gamma
PRSS23 protease, serine, 23
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PYCR1 pyrroline-5-carboxylate reductase 1
QPRT quinolinate phosphoribosyltransferase
RAB15 RAB15, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBMS1 RNA binding motif, single stranded interacting protein 1
RBPMS RNA binding protein with multiple splicing
RDX radixin
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SGCE sarcoglycan, epsilon
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAP25 synaptosomal-associated protein, 25kDa
SNX10 sorting nexin 10
SORBS3 sorbin and SH3 domain containing 3
SPON1 spondin 1, extracellular matrix protein
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
SST somatostatin
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNPO synaptopodin
TCERG1 transcription elongation regulator 1
TF transferrin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TLE2 transducin-like enhancer of split 2
TM4SF1 transmembrane 4 L six family member 1
TNS1 tensin 1
TPM1 tropomyosin 1 (alpha)
TRAF3IP3 TRAF3 interacting protein 3
TRBC1 T cell receptor beta constant 1
UBE2E1 ubiquitin-conjugating enzyme E2E 1
VAV3 vav 3 guanine nucleotide exchange factor
VCAM1 vascular cell adhesion molecule 1
VCAN versican
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WFDC2 WAP four-disulfide core domain 2
ZMYND8 zinc finger, MYND-type containing 8