BRD-K36363294_I-BET151_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

144 genes differentially expressed following the BRD-K36363294_I-BET151_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
AHNAK2 AHNAK nucleoprotein 2
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALCAM activated leukocyte cell adhesion molecule
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANXA3 annexin A3
ASMTL acetylserotonin O-methyltransferase-like
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C9ORF16 chromosome 9 open reading frame 16
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAPG capping protein (actin filament), gelsolin-like
CCNG2 cyclin G2
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD99 CD99 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CH25H cholesterol 25-hydroxylase
CLIC3 chloride intracellular channel 3
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CPA3 carboxypeptidase A3 (mast cell)
CYBA cytochrome b-245, alpha polypeptide
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP1 dual specificity phosphatase 1
EFNB2 ephrin-B2
ENAH enabled homolog (Drosophila)
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPHA3 EPH receptor A3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETV1 ets variant 1
EZR ezrin
F3 coagulation factor III (thromboplastin, tissue factor)
FLRT2 fibronectin leucine rich transmembrane protein 2
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GJA1 gap junction protein, alpha 1, 43kDa
GM2A GM2 ganglioside activator
GPATCH8 G patch domain containing 8
GPX2 glutathione peroxidase 2
GREM1 gremlin 1, DAN family BMP antagonist
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HSPA1A heat shock 70kDa protein 1A
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
JAK1 Janus kinase 1
LCN2 lipocalin 2
LIMCH1 LIM and calponin homology domains 1
MMP1 matrix metallopeptidase 1
MYO6 myosin VI
NDNF neuron-derived neurotrophic factor
NEBL nebulette
NQO1 NAD(P)H dehydrogenase, quinone 1
PCDH9 protocadherin 9
PELI2 pellino E3 ubiquitin protein ligase family member 2
PLS1 plastin 1
PNKP polynucleotide kinase 3'-phosphatase
PTPRD protein tyrosine phosphatase, receptor type, D
RPS4Y1 ribosomal protein S4, Y-linked 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC16A6 solute carrier family 16, member 6
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SQSTM1 sequestosome 1
STXBP1 syntaxin binding protein 1
TM7SF2 transmembrane 7 superfamily member 2
TMEM47 transmembrane protein 47
TTC39A tetratricopeptide repeat domain 39A
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAT1 vesicle amine transport 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
WLS wntless Wnt ligand secretion mediator
ZFP36 ZFP36 ring finger protein
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
ATP13A3 ATPase type 13A3
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BST2 bone marrow stromal cell antigen 2
CA12 carbonic anhydrase XII
CCDC86 coiled-coil domain containing 86
CCL20 chemokine (C-C motif) ligand 20
CCNA2 cyclin A2
CD163 CD163 molecule
CHEK1 checkpoint kinase 1
COL3A1 collagen, type III, alpha 1
COL4A2 collagen, type IV, alpha 2
CXCL14 chemokine (C-X-C motif) ligand 14
DHRS3 dehydrogenase/reductase (SDR family) member 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
EMX2 empty spiracles homeobox 2
ESR1 estrogen receptor 1
FAM216A family with sequence similarity 216, member A
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
FXYD5 FXYD domain containing ion transport regulator 5
GBP2 guanylate binding protein 2, interferon-inducible
GRWD1 glutamate-rich WD repeat containing 1
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HOXA10 homeobox A10
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL2RB interleukin 2 receptor, beta
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5
JADE2 jade family PHD finger 2
KRT18 keratin 18, type I
KRT5 keratin 5, type II
LTF lactotransferrin
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MECOM MDS1 and EVI1 complex locus
MOK MOK protein kinase
MT1E metallothionein 1E
NOP16 NOP16 nucleolar protein
PBK PDZ binding kinase
PCOLCE procollagen C-endopeptidase enhancer
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTX3 pentraxin 3, long
PYCR1 pyrroline-5-carboxylate reductase 1
RAB13 RAB13, member RAS oncogene family
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RFC3 replication factor C (activator 1) 3, 38kDa
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFRP1 secreted frizzled-related protein 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SNX10 sorting nexin 10
SORBS2 sorbin and SH3 domain containing 2
SORBS3 sorbin and SH3 domain containing 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TMPRSS3 transmembrane protease, serine 3