BRD-K36055864_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-K36055864_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AQP1 aquaporin 1 (Colton blood group)
AQP3 aquaporin 3 (Gill blood group)
ARID4B AT rich interactive domain 4B (RBP1-like)
BRD4 bromodomain containing 4
BTG3 BTG family, member 3
CA2 carbonic anhydrase II
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CHIC2 cysteine-rich hydrophobic domain 2
CLIC4 chloride intracellular channel 4
CLU clusterin
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP6 dual specificity phosphatase 6
EFNA1 ephrin-A1
EGR1 early growth response 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FGG fibrinogen gamma chain
FNDC3B fibronectin type III domain containing 3B
FOXO1 forkhead box O1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
H1F0 H1 histone family, member 0
HES1 hes family bHLH transcription factor 1
HHEX hematopoietically expressed homeobox
HIST1H4C histone cluster 1, H4c
HOXA5 homeobox A5
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IKZF1 IKAROS family zinc finger 1 (Ikaros)
INHBA inhibin, beta A
INHBB inhibin, beta B
INPP1 inositol polyphosphate-1-phosphatase
JUN jun proto-oncogene
KDM5B lysine (K)-specific demethylase 5B
KLF10 Kruppel-like factor 10
LGALS8 lectin, galactoside-binding, soluble, 8
MED13 mediator complex subunit 13
MMP9 matrix metallopeptidase 9
MTUS1 microtubule associated tumor suppressor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NRIP1 nuclear receptor interacting protein 1
PDE8B phosphodiesterase 8B
PLK2 polo-like kinase 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLVAP plasmalemma vesicle associated protein
PLXNC1 plexin C1
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRRC2C proline-rich coiled-coil 2C
QKI QKI, KH domain containing, RNA binding
RDX radixin
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RYBP RING1 and YY1 binding protein
S100A8 S100 calcium binding protein A8
SCAF11 SR-related CTD-associated factor 11
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP1 secreted frizzled-related protein 1
SMAD3 SMAD family member 3
SON SON DNA binding protein
SOX4 SRY (sex determining region Y)-box 4
SRP72 signal recognition particle 72kDa
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TXNIP thioredoxin interacting protein
UBXN4 UBX domain protein 4
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
AIM1 absent in melanoma 1
ANPEP alanyl (membrane) aminopeptidase
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
C6ORF62 chromosome 6 open reading frame 62
CANT1 calcium activated nucleotidase 1
CCNG1 cyclin G1
CDC25B cell division cycle 25B
CSK c-src tyrosine kinase
CSTA cystatin A (stefin A)
DCN decorin
DEGS1 delta(4)-desaturase, sphingolipid 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF5 eukaryotic translation initiation factor 5
FAM102A family with sequence similarity 102, member A
FAM57A family with sequence similarity 57, member A
GDE1 glycerophosphodiester phosphodiesterase 1
GLRB glycine receptor, beta
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GSTP1 glutathione S-transferase pi 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSPA8 heat shock 70kDa protein 8
IGKV4-1 immunoglobulin kappa variable 4-1
IGLV2-23 immunoglobulin lambda variable 2-23
MAGED1 melanoma antigen family D1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MME membrane metallo-endopeptidase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
OLFM4 olfactomedin 4
PGK1 phosphoglycerate kinase 1
PIR pirin (iron-binding nuclear protein)
PKM pyruvate kinase, muscle
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRPF4 pre-mRNA processing factor 4
PRUNE2 prune homolog 2 (Drosophila)
PSAT1 phosphoserine aminotransferase 1
RAP2A RAP2A, member of RAS oncogene family
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SRPX sushi-repeat containing protein, X-linked
STC1 stanniocalcin 1
SYBU syntabulin (syntaxin-interacting)
TMC5 transmembrane channel-like 5
TMEM97 transmembrane protein 97
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5
TXN thioredoxin
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VDAC1 voltage-dependent anion channel 1