BRD-K35716340_-666_HEPG2_6.0_h_12.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

89 genes differentially expressed following the BRD-K35716340_-666_HEPG2_6.0_h_12.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM10 ADAM metallopeptidase domain 10
AIM1 absent in melanoma 1
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALOX5 arachidonate 5-lipoxygenase
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
CA12 carbonic anhydrase XII
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
CPB1 carboxypeptidase B1 (tissue)
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL10 chemokine (C-X-C motif) ligand 10
CYB5R2 cytochrome b5 reductase 2
DCN decorin
DHRS2 dehydrogenase/reductase (SDR family) member 2
FABP7 fatty acid binding protein 7, brain
GNAS GNAS complex locus
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRB14 growth factor receptor-bound protein 14
HBB hemoglobin, beta
IFNAR1 interferon (alpha, beta and omega) receptor 1
IRF6 interferon regulatory factor 6
KRT15 keratin 15, type I
LIMCH1 LIM and calponin homology domains 1
LYZ lysozyme
MMP7 matrix metallopeptidase 7
NMU neuromedin U
NOX4 NADPH oxidase 4
NT5DC2 5'-nucleotidase domain containing 2
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9
PCLO piccolo presynaptic cytomatrix protein
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RFTN1 raftlin, lipid raft linker 1
S100A8 S100 calcium binding protein A8
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFRP1 secreted frizzled-related protein 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SORBS2 sorbin and SH3 domain containing 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TOP2A topoisomerase (DNA) II alpha 170kDa
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIM2 tripartite motif containing 2
TSPAN12 tetraspanin 12
ZNF185 zinc finger protein 185 (LIM domain)

decreased expression

Symbol Name
ASMTL acetylserotonin O-methyltransferase-like
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
CAV1 caveolin 1, caveolae protein, 22kDa
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHN1 chimerin 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FN1 fibronectin 1
GAS1 growth arrest-specific 1
GPM6B glycoprotein M6B
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
ITM2A integral membrane protein 2A
JMJD6 jumonji domain containing 6
KIAA0125 KIAA0125
LAPTM4B lysosomal protein transmembrane 4 beta
LYPLA1 lysophospholipase I
MXRA5 matrix-remodelling associated 5
OXA1L oxidase (cytochrome c) assembly 1-like
PDLIM1 PDZ and LIM domain 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLS3 plastin 3
PSPH phosphoserine phosphatase
PXDN peroxidasin
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
SEPP1 selenoprotein P, plasma, 1
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC35B1 solute carrier family 35, member B1
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TLR4 toll-like receptor 4
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOB1 transducer of ERBB2, 1
TPM4 tropomyosin 4
TSPAN3 tetraspanin 3
TUBB6 tubulin, beta 6 class V
ZFP36L1 ZFP36 ring finger protein-like 1