BRD-K35559145_Methotrimeprazine maleat salt_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

116 genes differentially expressed following the BRD-K35559145_Methotrimeprazine maleat salt_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACPP acid phosphatase, prostate
ACSL1 acyl-CoA synthetase long-chain family member 1
AIM1 absent in melanoma 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
C5AR1 complement component 5a receptor 1
CD14 CD14 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CKAP4 cytoskeleton-associated protein 4
CLCN3 chloride channel, voltage-sensitive 3
CNPY3 canopy FGF signaling regulator 3
COG7 component of oligomeric golgi complex 7
COL1A2 collagen, type I, alpha 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSTA cystatin A (stefin A)
CTSH cathepsin H
CXCR4 chemokine (C-X-C motif) receptor 4
ELOVL5 ELOVL fatty acid elongase 5
ERAP2 endoplasmic reticulum aminopeptidase 2
EREG epiregulin
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FASTKD5 FAST kinase domains 5
FCN1 ficolin (collagen/fibrinogen domain containing) 1
G6PD glucose-6-phosphate dehydrogenase
GJA1 gap junction protein, alpha 1, 43kDa
KLK2 kallikrein-related peptidase 2
KLK3 kallikrein-related peptidase 3
KRT23 keratin 23, type I
KYNU kynureninase
LCN2 lipocalin 2
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LPAR6 lysophosphatidic acid receptor 6
LTF lactotransferrin
MAOA monoamine oxidase A
MNDA myeloid cell nuclear differentiation antigen
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MSMB microseminoprotein, beta-
NEB nebulin
NR1H2 nuclear receptor subfamily 1, group H, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
P3H2 prolyl 3-hydroxylase 2
PDE4B phosphodiesterase 4B, cAMP-specific
PDLIM5 PDZ and LIM domain 5
PGD phosphogluconate dehydrogenase
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPAP2B phosphatidic acid phosphatase type 2B
PRUNE2 prune homolog 2 (Drosophila)
PTK2 protein tyrosine kinase 2
QPCT glutaminyl-peptide cyclotransferase
RGCC regulator of cell cycle
RTN1 reticulon 1
S100A12 S100 calcium binding protein A12
S100A6 S100 calcium binding protein A6
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB1D2 secretoglobin, family 1D, member 2
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SNAP25 synaptosomal-associated protein, 25kDa
TACSTD2 tumor-associated calcium signal transducer 2
TGM2 transglutaminase 2
TLK2 tousled-like kinase 2
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPPP3 tubulin polymerization-promoting protein family member 3
VAV3 vav 3 guanine nucleotide exchange factor
WNT5A wingless-type MMTV integration site family, member 5A
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
ACACB acetyl-CoA carboxylase beta
ACAT1 acetyl-CoA acetyltransferase 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ASPN asporin
BANP BTG3 associated nuclear protein
BZW1 basic leucine zipper and W2 domains 1
C8ORF4 chromosome 8 open reading frame 4
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHIC2 cysteine-rich hydrophobic domain 2
CNOT7 CCR4-NOT transcription complex, subunit 7
CPT1A carnitine palmitoyltransferase 1A (liver)
DKK3 dickkopf WNT signaling pathway inhibitor 3
FABP1 fatty acid binding protein 1, liver
FRZB frizzled-related protein
GPM6B glycoprotein M6B
HOXA5 homeobox A5
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYPLA1 lysophospholipase I
MXRA7 matrix-remodelling associated 7
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PLS3 plastin 3
PROM1 prominin 1
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
QDPR quinoid dihydropteridine reductase
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RPL37A ribosomal protein L37a
RPS11 ribosomal protein S11
SCG5 secretogranin V
SPINK1 serine peptidase inhibitor, Kazal type 1
SULF1 sulfatase 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM97 transmembrane protein 97
TOX thymocyte selection-associated high mobility group box
TSPAN3 tetraspanin 3