BRD-K34581968_BMS-536924_SKMEL28_6.0_h_11.1_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

144 genes differentially expressed following the BRD-K34581968_BMS-536924_SKMEL28_6.0_h_11.1_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACKR3 atypical chemokine receptor 3
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANXA4 annexin A4
APP amyloid beta (A4) precursor protein
ASS1 argininosuccinate synthase 1
BMP2 bone morphogenetic protein 2
C10ORF10 chromosome 10 open reading frame 10
CA1 carbonic anhydrase I
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CHEK1 checkpoint kinase 1
CKB creatine kinase, brain
CLEC2B C-type lectin domain family 2, member B
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EXPH5 exophilin 5
EXT1 exostosin glycosyltransferase 1
FAM69A family with sequence similarity 69, member A
FHL1 four and a half LIM domains 1
GJA1 gap junction protein, alpha 1, 43kDa
IFNAR1 interferon (alpha, beta and omega) receptor 1
INSR insulin receptor
JAG1 jagged 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
MTSS1 metastasis suppressor 1
NEB nebulin
NNMT nicotinamide N-methyltransferase
NPTX2 neuronal pentraxin II
NUPR1 nuclear protein, transcriptional regulator, 1
NVL nuclear VCP-like
PAPD7 PAP associated domain containing 7
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX1 pre-B-cell leukemia homeobox 1
PCP4 Purkinje cell protein 4
PLEKHA5 pleckstrin homology domain containing, family A member 5
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RGCC regulator of cell cycle
RPL37A ribosomal protein L37a
RTN2 reticulon 2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SEPP1 selenoprotein P, plasma, 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SIK1 salt-inducible kinase 1
SLC38A1 solute carrier family 38, member 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SPON1 spondin 1, extracellular matrix protein
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRGN serglycin
STON1 stonin 1
SULF1 sulfatase 1
TLR4 toll-like receptor 4
TNS3 tensin 3
VCAM1 vascular cell adhesion molecule 1
VNN1 vanin 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

decreased expression

Symbol Name
ACAA1 acetyl-CoA acyltransferase 1
ACSL1 acyl-CoA synthetase long-chain family member 1
ADCY1 adenylate cyclase 1 (brain)
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
C8ORF4 chromosome 8 open reading frame 4
CHI3L2 chitinase 3-like 2
CHL1 cell adhesion molecule L1-like
CHPT1 choline phosphotransferase 1
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP6 dual specificity phosphatase 6
EGR3 early growth response 3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
F3 coagulation factor III (thromboplastin, tissue factor)
FAM129A family with sequence similarity 129, member A
FCMR Fc fragment of IgM receptor
FLNA filamin A, alpha
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GATA3 GATA binding protein 3
GDF15 growth differentiation factor 15
GNAS GNAS complex locus
H1F0 H1 histone family, member 0
HES1 hes family bHLH transcription factor 1
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOMER2 homer scaffolding protein 2
HOXC6 homeobox C6
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ITGA6 integrin, alpha 6
KLK10 kallikrein-related peptidase 10
KLK6 kallikrein-related peptidase 6
LDLR low density lipoprotein receptor
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LTF lactotransferrin
MARCKSL1 MARCKS-like 1
MKNK2 MAP kinase interacting serine/threonine kinase 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MPP1 membrane protein, palmitoylated 1, 55kDa
NFIB nuclear factor I/B
NPY neuropeptide Y
NRN1 neuritin 1
NUP98 nucleoporin 98kDa
PCDH9 protocadherin 9
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTX3 pentraxin 3, long
RALB v-ral simian leukemia viral oncogene homolog B
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBMS1 RNA binding motif, single stranded interacting protein 1
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
S100A10 S100 calcium binding protein A10
S100B S100 calcium binding protein B
SELL selectin L
SFRP1 secreted frizzled-related protein 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLPI secretory leukocyte peptidase inhibitor
SMC1A structural maintenance of chromosomes 1A
SRPX sushi-repeat containing protein, X-linked
STK39 serine threonine kinase 39
TACSTD2 tumor-associated calcium signal transducer 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNC tenascin C
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRBC1 T cell receptor beta constant 1
TRIM2 tripartite motif containing 2
TSPAN8 tetraspanin 8
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)