BRD-K33720394_(S)-1,1-dimethyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid JAS07_00S_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

214 genes differentially expressed following the BRD-K33720394_(S)-1,1-dimethyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid JAS07_00S_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACOT7 acyl-CoA thioesterase 7
AFF1 AF4/FMR2 family, member 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDOC aldolase C, fructose-bisphosphate
ANK2 ankyrin 2, neuronal
ANOS1 anosmin 1
ATG2A autophagy related 2A
ATG5 autophagy related 5
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
BIK BCL2-interacting killer (apoptosis-inducing)
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BSG basigin (Ok blood group)
BST2 bone marrow stromal cell antigen 2
C1QTNF3 C1q and tumor necrosis factor related protein 3
C7 complement component 7
CALCOCO2 calcium binding and coiled-coil domain 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCL20 chemokine (C-C motif) ligand 20
CCL5 chemokine (C-C motif) ligand 5
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CEMIP cell migration inducing protein, hyaluronan binding
CHEK2 checkpoint kinase 2
CIB1 calcium and integrin binding 1 (calmyrin)
CKB creatine kinase, brain
CORO1A coronin, actin binding protein, 1A
CP ceruloplasmin (ferroxidase)
CPM carboxypeptidase M
CTH cystathionine gamma-lyase
DAPK1 death-associated protein kinase 1
DES desmin
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPYSL2 dihydropyrimidinase-like 2
DUSP5 dual specificity phosphatase 5
EPAS1 endothelial PAS domain protein 1
FABP3 fatty acid binding protein 3, muscle and heart
FADS1 fatty acid desaturase 1
FAM107A family with sequence similarity 107, member A
FAM46A family with sequence similarity 46, member A
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO4 forkhead box O4
GADD45B growth arrest and DNA-damage-inducible, beta
GLRX glutaredoxin (thioltransferase)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPM6A glycoprotein M6A
GRK5 G protein-coupled receptor kinase 5
GSTP1 glutathione S-transferase pi 1
HN1 hematological and neurological expressed 1
HNMT histamine N-methyltransferase
HRSP12 heat-responsive protein 12
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INSIG1 insulin induced gene 1
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA1033 KIAA1033
LDHB lactate dehydrogenase B
LEFTY1 left-right determination factor 1
LGALS1 lectin, galactoside-binding, soluble, 1
LGMN legumain
LIPA lipase A, lysosomal acid, cholesterol esterase
LPIN1 lipin 1
LPIN2 lipin 2
LRRC17 leucine rich repeat containing 17
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLF1 myeloid leukemia factor 1
NBL1 neuroblastoma 1, DAN family BMP antagonist
NCAM1 neural cell adhesion molecule 1
NOSIP nitric oxide synthase interacting protein
NPC1 Niemann-Pick disease, type C1
OLFML3 olfactomedin-like 3
PBX3 pre-B-cell leukemia homeobox 3
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCCA propionyl CoA carboxylase, alpha polypeptide
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PLA2G15 phospholipase A2, group XV
PLD3 phospholipase D family, member 3
PNMA2 paraneoplastic Ma antigen 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRAF2 PRA1 domain family, member 2
PRSS3 protease, serine, 3
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAD9A RAD9 homolog A (S. pombe)
REEP1 receptor accessory protein 1
RNASET2 ribonuclease T2
RNF167 ring finger protein 167
RNMT RNA (guanine-7-) methyltransferase
SCPEP1 serine carboxypeptidase 1
SKAP2 src kinase associated phosphoprotein 2
SKP1 S-phase kinase-associated protein 1
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SNAP23 synaptosomal-associated protein, 23kDa
SORBS1 sorbin and SH3 domain containing 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRGN serglycin
SRPX sushi-repeat containing protein, X-linked
SST somatostatin
STOM stomatin
STX1A syntaxin 1A (brain)
STXBP1 syntaxin binding protein 1
SYNM synemin, intermediate filament protein
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TRAK2 trafficking protein, kinesin binding 2
TSPAN3 tetraspanin 3
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCL vinculin
VIM vimentin
WIPI1 WD repeat domain, phosphoinositide interacting 1
WWTR1 WW domain containing transcription regulator 1
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ALCAM activated leukocyte cell adhesion molecule
AQP9 aquaporin 9
ARID1A AT rich interactive domain 1A (SWI-like)
ATF5 activating transcription factor 5
AUTS2 autism susceptibility candidate 2
BCL6 B-cell CLL/lymphoma 6
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CCND1 cyclin D1
CD24 CD24 molecule
CD58 CD58 molecule
CFLAR CASP8 and FADD-like apoptosis regulator
CKAP4 cytoskeleton-associated protein 4
COMT catechol-O-methyltransferase
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
DCK deoxycytidine kinase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DST dystonin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF4B eukaryotic translation initiation factor 4B
EIF5A eukaryotic translation initiation factor 5A
EPCAM epithelial cell adhesion molecule
EREG epiregulin
ESR1 estrogen receptor 1
FAM57A family with sequence similarity 57, member A
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA3 GATA binding protein 3
GLUL glutamate-ammonia ligase
GREM1 gremlin 1, DAN family BMP antagonist
HDGF hepatoma-derived growth factor
HIRA histone cell cycle regulator
IGF1R insulin-like growth factor 1 receptor
IGFBP7 insulin-like growth factor binding protein 7
IL27RA interleukin 27 receptor, alpha
JADE2 jade family PHD finger 2
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KEAP1 kelch-like ECH-associated protein 1
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT19 keratin 19, type I
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
LTF lactotransferrin
MECOM MDS1 and EVI1 complex locus
MLPH melanophilin
MSL1 male-specific lethal 1 homolog (Drosophila)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFE2L2 nuclear factor, erythroid 2-like 2
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
PARP2 poly (ADP-ribose) polymerase 2
PDGFA platelet-derived growth factor alpha polypeptide
PDZK1 PDZ domain containing 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK2 polo-like kinase 2
POSTN periostin, osteoblast specific factor
PPAP2B phosphatidic acid phosphatase type 2B
PRR7 proline rich 7 (synaptic)
RAB25 RAB25, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
RGCC regulator of cell cycle
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP1 secreted frizzled-related protein 1
SH3BP4 SH3-domain binding protein 4
SMYD2 SET and MYND domain containing 2
SPAG7 sperm associated antigen 7
SPON2 spondin 2, extracellular matrix protein
SPRY2 sprouty homolog 2 (Drosophila)
STC2 stanniocalcin 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TBX2 T-box 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGIF1 TGFB-induced factor homeobox 1
THBS1 thrombospondin 1
TSKU tsukushi, small leucine rich proteoglycan
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VCAN versican
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFP36L2 ZFP36 ring finger protein-like 2
ZHX2 zinc fingers and homeoboxes 2