BRD-K33720394_(S)-1,1-dimethyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid JAS07_00S_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

204 genes differentially expressed following the BRD-K33720394_(S)-1,1-dimethyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid JAS07_00S_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABHD3 abhydrolase domain containing 3
ACOT7 acyl-CoA thioesterase 7
ADAM10 ADAM metallopeptidase domain 10
ADCY9 adenylate cyclase 9
AK1 adenylate kinase 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDOC aldolase C, fructose-bisphosphate
AMDHD2 amidohydrolase domain containing 2
ANXA5 annexin A5
ANXA6 annexin A6
ARHGAP29 Rho GTPase activating protein 29
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BAG3 BCL2-associated athanogene 3
BLVRA biliverdin reductase A
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCND3 cyclin D3
CDK2 cyclin-dependent kinase 2
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CETN2 centrin, EF-hand protein, 2
CHPT1 choline phosphotransferase 1
CIB1 calcium and integrin binding 1 (calmyrin)
CRIP1 cysteine-rich protein 1 (intestinal)
CTR9 CTR9, Paf1/RNA polymerase II complex component
CTSV cathepsin V
CYB5R1 cytochrome b5 reductase 1
DLD dihydrolipoamide dehydrogenase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EDNRB endothelin receptor type B
ENAH enabled homolog (Drosophila)
FAM117A family with sequence similarity 117, member A
FLNA filamin A, alpha
FN1 fibronectin 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO4 forkhead box O4
G6PD glucose-6-phosphate dehydrogenase
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GLRX glutaredoxin (thioltransferase)
GLS glutaminase
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
HLTF helicase-like transcription factor
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
HPCAL1 hippocalcin-like 1
HSDL2 hydroxysteroid dehydrogenase like 2
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI6 interferon, alpha-inducible protein 6
IFT20 intraflagellar transport 20
IFT57 intraflagellar transport 57
INSIG1 insulin induced gene 1
KCTD5 potassium channel tetramerization domain containing 5
LEF1 lymphoid enhancer-binding factor 1
LGMN legumain
LINC00094 long intergenic non-protein coding RNA 94
LIPA lipase A, lysosomal acid, cholesterol esterase
LPIN1 lipin 1
MAGED1 melanoma antigen family D1
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
METRN meteorin, glial cell differentiation regulator
MLF1 myeloid leukemia factor 1
MPZL1 myelin protein zero-like 1
MXRA7 matrix-remodelling associated 7
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
NEU1 sialidase 1 (lysosomal sialidase)
NOSIP nitric oxide synthase interacting protein
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
OAT ornithine aminotransferase
OPN3 opsin 3
OSBPL8 oxysterol binding protein-like 8
OSTM1 osteopetrosis associated transmembrane protein 1
PALLD palladin, cytoskeletal associated protein
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PLA2G15 phospholipase A2, group XV
PLD3 phospholipase D family, member 3
PMEL premelanosome protein
PRKCD protein kinase C, delta
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAD9A RAD9 homolog A (S. pombe)
RAP1GAP RAP1 GTPase activating protein
RB1CC1 RB1-inducible coiled-coil 1
RFK riboflavin kinase
RHOB ras homolog family member B
RIMS3 regulating synaptic membrane exocytosis 3
ROGDI rogdi homolog (Drosophila)
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RTN3 reticulon 3
RUNX3 runt-related transcription factor 3
SCPEP1 serine carboxypeptidase 1
SEPHS2 selenophosphate synthetase 2
SEPT6 septin 6
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SHANK2 SH3 and multiple ankyrin repeat domains 2
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC31A1 solute carrier family 31 (copper transporter), member 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SNAP23 synaptosomal-associated protein, 23kDa
SNN stannin
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
STX1A syntaxin 1A (brain)
STXBP1 syntaxin binding protein 1
TBPL1 TBP-like 1
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM41B transmembrane protein 41B
TOB1 transducer of ERBB2, 1
TPST2 tyrosylprotein sulfotransferase 2
TRAK2 trafficking protein, kinesin binding 2
TSPAN13 tetraspanin 13
TSPAN4 tetraspanin 4
TUBA1A tubulin, alpha 1a
TUFT1 tuftelin 1
VAMP7 vesicle-associated membrane protein 7
VAT1 vesicle amine transport 1
VIM vimentin
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ANXA10 annexin A10
ARID1A AT rich interactive domain 1A (SWI-like)
ATF5 activating transcription factor 5
BMP4 bone morphogenetic protein 4
BPTF bromodomain PHD finger transcription factor
C2CD5 C2 calcium-dependent domain containing 5
CCND2 cyclin D2
CFLAR CASP8 and FADD-like apoptosis regulator
COL4A6 collagen, type IV, alpha 6
COMT catechol-O-methyltransferase
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CTSO cathepsin O
CTSS cathepsin S
CXCL11 chemokine (C-X-C motif) ligand 11
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DENND2D DENN/MADD domain containing 2D
DPYSL3 dihydropyrimidinase-like 3
EIF4A1 eukaryotic translation initiation factor 4A1
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ERAP2 endoplasmic reticulum aminopeptidase 2
EREG epiregulin
FAM129A family with sequence similarity 129, member A
FAM57A family with sequence similarity 57, member A
FAM60A family with sequence similarity 60, member A
FANCL Fanconi anemia, complementation group L
FERMT1 fermitin family member 1
FILIP1L filamin A interacting protein 1-like
FNDC3B fibronectin type III domain containing 3B
FOSL1 FOS-like antigen 1
GPNMB glycoprotein (transmembrane) nmb
GPX2 glutathione peroxidase 2
GSAP gamma-secretase activating protein
GTPBP8 GTP-binding protein 8 (putative)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HMGB2 high mobility group box 2
IDO1 indoleamine 2,3-dioxygenase 1
JADE2 jade family PHD finger 2
KANK1 KN motif and ankyrin repeat domains 1
KEAP1 kelch-like ECH-associated protein 1
KRT13 keratin 13, type I
LTF lactotransferrin
MECOM MDS1 and EVI1 complex locus
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH11 myosin, heavy chain 11, smooth muscle
MYO5C myosin VC
NRIP1 nuclear receptor interacting protein 1
OBSL1 obscurin-like 1
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
PAX6 paired box 6
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK1 polo-like kinase 1
PLN phospholamban
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PUF60 poly-U binding splicing factor 60KDa
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPL10 ribosomal protein L10
SLC35F2 solute carrier family 35, member F2
SPARCL1 SPARC-like 1 (hevin)
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRR3 small proline-rich protein 3
SPRY2 sprouty homolog 2 (Drosophila)
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCERG1 transcription elongation regulator 1
TDO2 tryptophan 2,3-dioxygenase
UBE2E3 ubiquitin-conjugating enzyme E2E 3
VWF von Willebrand factor
XIST X inactive specific transcript (non-protein coding)
ZFP36L2 ZFP36 ring finger protein-like 2