BRD-K33720394_(S)-1,1-dimethyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid JAS07_00S_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

249 genes differentially expressed following the BRD-K33720394_(S)-1,1-dimethyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid JAS07_00S_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ALDOC aldolase C, fructose-bisphosphate
ANOS1 anosmin 1
ARHGAP29 Rho GTPase activating protein 29
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BSG basigin (Ok blood group)
BZW2 basic leucine zipper and W2 domains 2
C10ORF10 chromosome 10 open reading frame 10
C1QB complement component 1, q subcomponent, B chain
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CD36 CD36 molecule (thrombospondin receptor)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD69 CD69 molecule
CD9 CD9 molecule
CD99 CD99 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEMIP cell migration inducing protein, hyaluronan binding
CERS6 ceramide synthase 6
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COLEC12 collectin sub-family member 12
CORO1A coronin, actin binding protein, 1A
CTSA cathepsin A
CYB5R1 cytochrome b5 reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAPK1 death-associated protein kinase 1
DCN decorin
DCXR dicarbonyl/L-xylulose reductase
DUSP14 dual specificity phosphatase 14
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNB2 ephrin-B2
ELOVL5 ELOVL fatty acid elongase 5
EPAS1 endothelial PAS domain protein 1
FAM117A family with sequence similarity 117, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FN1 fibronectin 1
FOXN3 forkhead box N3
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
GAS1 growth arrest-specific 1
GLS glutaminase
GPX3 glutathione peroxidase 3
GRN granulin
GSDMB gasdermin B
GSTA4 glutathione S-transferase alpha 4
HEBP1 heme binding protein 1
HECA headcase homolog (Drosophila)
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPA1A heat shock 70kDa protein 1A
ICAM1 intercellular adhesion molecule 1
IFT20 intraflagellar transport 20
IQCG IQ motif containing G
IQGAP2 IQ motif containing GTPase activating protein 2
IRF7 interferon regulatory factor 7
ITM2A integral membrane protein 2A
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
LAMP2 lysosomal-associated membrane protein 2
LAPTM5 lysosomal protein transmembrane 5
LIMA1 LIM domain and actin binding 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOB monoamine oxidase B
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MAPT microtubule-associated protein tau
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
MBNL2 muscleblind-like splicing regulator 2
MCOLN1 mucolipin 1
MLF1 myeloid leukemia factor 1
MNDA myeloid cell nuclear differentiation antigen
MOSPD1 motile sperm domain containing 1
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NGRN neugrin, neurite outgrowth associated
NID2 nidogen 2 (osteonidogen)
NOSIP nitric oxide synthase interacting protein
NPC1 Niemann-Pick disease, type C1
NXN nucleoredoxin
OPN3 opsin 3
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PLA2G15 phospholipase A2, group XV
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRDM2 PR domain containing 2, with ZNF domain
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRUNE2 prune homolog 2 (Drosophila)
PSPH phosphoserine phosphatase
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PXDN peroxidasin
RAD9A RAD9 homolog A (S. pombe)
REEP1 receptor accessory protein 1
RETSAT retinol saturase (all-trans-retinol 13,14-reductase)
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIMS3 regulating synaptic membrane exocytosis 3
RRAGC Ras-related GTP binding C
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SARAF store-operated calcium entry-associated regulatory factor
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SELL selectin L
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SKAP2 src kinase associated phosphoprotein 2
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC46A3 solute carrier family 46, member 3
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SNN stannin
SORT1 sortilin 1
SOX11 SRY (sex determining region Y)-box 11
SPTSSA serine palmitoyltransferase, small subunit A
SRPX sushi-repeat containing protein, X-linked
STAR steroidogenic acute regulatory protein
TBC1D4 TBC1 domain family, member 4
TBPL1 TBP-like 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TM7SF2 transmembrane 7 superfamily member 2
TMSB15A thymosin beta 15a
TPP1 tripeptidyl peptidase I
TPST2 tyrosylprotein sulfotransferase 2
TSPAN13 tetraspanin 13
TSPAN31 tetraspanin 31
TSPAN7 tetraspanin 7
TTC39A tetratricopeptide repeat domain 39A
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WDTC1 WD and tetratricopeptide repeats 1
WFS1 Wolfram syndrome 1 (wolframin)
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZBTB18 zinc finger and BTB domain containing 18
ZNF451 zinc finger protein 451
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ATP13A3 ATPase type 13A3
BEX1 brain expressed, X-linked 1
BHMT betaine--homocysteine S-methyltransferase
CA12 carbonic anhydrase XII
CAPN2 calpain 2, (m/II) large subunit
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND1 cyclin D1
CKAP4 cytoskeleton-associated protein 4
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DIO2 deiodinase, iodothyronine, type II
DKK1 dickkopf WNT signaling pathway inhibitor 1
DRAM1 DNA-damage regulated autophagy modulator 1
EDN1 endothelin 1
EMP3 epithelial membrane protein 3
EPN2 epsin 2
EREG epiregulin
ESR1 estrogen receptor 1
FAM57A family with sequence similarity 57, member A
FBXL12 F-box and leucine-rich repeat protein 12
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GLI2 GLI family zinc finger 2
GPR171 G protein-coupled receptor 171
GPX2 glutathione peroxidase 2
GRWD1 glutamate-rich WD repeat containing 1
GSTO1 glutathione S-transferase omega 1
HDGF hepatoma-derived growth factor
HDGFRP3 hepatoma-derived growth factor, related protein 3
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HOXA10 homeobox A10
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGHMBP2 immunoglobulin mu binding protein 2
IL7R interleukin 7 receptor
IRS1 insulin receptor substrate 1
JADE2 jade family PHD finger 2
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KEAP1 kelch-like ECH-associated protein 1
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAPK6 mitogen-activated protein kinase 6
MECOM MDS1 and EVI1 complex locus
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
MRPL15 mitochondrial ribosomal protein L15
MYOF myoferlin
N4BP2L2 NEDD4 binding protein 2-like 2
NBN nibrin
NFE2L2 nuclear factor, erythroid 2-like 2
NRIP1 nuclear receptor interacting protein 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
PARP2 poly (ADP-ribose) polymerase 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIR pirin (iron-binding nuclear protein)
PLK1 polo-like kinase 1
PLS1 plastin 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSCA prostate stem cell antigen
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PWP1 PWP1 homolog (S. cerevisiae)
RPIA ribose 5-phosphate isomerase A
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RTP4 receptor (chemosensory) transporter protein 4
S100P S100 calcium binding protein P
SALL1 spalt-like transcription factor 1
SFRP1 secreted frizzled-related protein 1
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SMAD3 SMAD family member 3
SORBS3 sorbin and SH3 domain containing 3
SORD sorbitol dehydrogenase
SPRY2 sprouty homolog 2 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCERG1 transcription elongation regulator 1
TFF1 trefoil factor 1
TIMELESS timeless circadian clock
TSKU tsukushi, small leucine rich proteoglycan
TUSC3 tumor suppressor candidate 3
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UPK1B uroplakin 1B
WNT5A wingless-type MMTV integration site family, member 5A