BRD-K33720394_(S)-1,1-dimethyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid JAS07_00S_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

161 genes differentially expressed following the BRD-K33720394_(S)-1,1-dimethyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid JAS07_00S_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ACTG2 actin, gamma 2, smooth muscle, enteric
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALOX5 arachidonate 5-lipoxygenase
ARHGAP29 Rho GTPase activating protein 29
ARID5B AT rich interactive domain 5B (MRF1-like)
ASRGL1 asparaginase like 1
ASS1 argininosuccinate synthase 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BST2 bone marrow stromal cell antigen 2
BZW2 basic leucine zipper and W2 domains 2
C14ORF132 chromosome 14 open reading frame 132
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CFD complement factor D (adipsin)
CORO1A coronin, actin binding protein, 1A
CPD carboxypeptidase D
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYB5R1 cytochrome b5 reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DES desmin
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSTN destrin (actin depolymerizing factor)
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFHD1 EF-hand domain family, member D1
EIF5A eukaryotic translation initiation factor 5A
F2RL1 coagulation factor II (thrombin) receptor-like 1
FOLR1 folate receptor 1 (adult)
FOXO4 forkhead box O4
G0S2 G0/G1 switch 2
G6PD glucose-6-phosphate dehydrogenase
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPX3 glutathione peroxidase 3
GSN gelsolin
HEBP1 heme binding protein 1
HOOK2 hook microtubule-tethering protein 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
IFI6 interferon, alpha-inducible protein 6
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ISG15 ISG15 ubiquitin-like modifier
KIAA0226L KIAA0226-like
LIPA lipase A, lysosomal acid, cholesterol esterase
LPIN1 lipin 1
MAN2B1 mannosidase, alpha, class 2B, member 1
MAOB monoamine oxidase B
MAP1B microtubule-associated protein 1B
MGP matrix Gla protein
MGST3 microsomal glutathione S-transferase 3
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MLF1 myeloid leukemia factor 1
MMD monocyte to macrophage differentiation-associated
MTUS1 microtubule associated tumor suppressor 1
MVP major vault protein
MX1 MX dynamin-like GTPase 1
NIT1 nitrilase 1
NME7 NME/NM23 family member 7
NTS neurotensin
OPN3 opsin 3
PLA2G15 phospholipase A2, group XV
PLA2G16 phospholipase A2, group XVI
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGDS prostaglandin D2 synthase 21kDa (brain)
RTN3 reticulon 3
SCPEP1 serine carboxypeptidase 1
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC46A3 solute carrier family 46, member 3
SORBS1 sorbin and SH3 domain containing 1
SSBP2 single-stranded DNA binding protein 2
SST somatostatin
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STX1A syntaxin 1A (brain)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM7SF2 transmembrane 7 superfamily member 2
TMSB15A thymosin beta 15a
TPM2 tropomyosin 2 (beta)
TSPAN13 tetraspanin 13
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WDTC1 WD and tetratricopeptide repeats 1
ZBTB18 zinc finger and BTB domain containing 18
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
AKAP8 A kinase (PRKA) anchor protein 8
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
CA2 carbonic anhydrase II
CBFB core-binding factor, beta subunit
CCND1 cyclin D1
CCND2 cyclin D2
COL5A2 collagen, type V, alpha 2
COMT catechol-O-methyltransferase
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
ELANE elastase, neutrophil expressed
EMG1 EMG1 N1-specific pseudouridine methyltransferase
FAM57A family with sequence similarity 57, member A
FKBP11 FK506 binding protein 11, 19 kDa
FXYD3 FXYD domain containing ion transport regulator 3
GSAP gamma-secretase activating protein
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HMGA2 high mobility group AT-hook 2
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
KIF18B kinesin family member 18B
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
MCM5 minichromosome maintenance complex component 5
MFAP5 microfibrillar associated protein 5
MOK MOK protein kinase
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NIP7 NIP7, nucleolar pre-rRNA processing protein
NOP2 NOP2 nucleolar protein
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
PMM2 phosphomannomutase 2
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RGS1 regulator of G-protein signaling 1
RRM2 ribonucleotide reductase M2
RSL1D1 ribosomal L1 domain containing 1
SCRN1 secernin 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
THBS1 thrombospondin 1
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
TYMS thymidylate synthetase
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VCAN versican
ZHX2 zinc fingers and homeoboxes 2
ZNF512B zinc finger protein 512B