BRD-K33379087_tivantinib_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

161 genes differentially expressed following the BRD-K33379087_tivantinib_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
ACTC1 actin, alpha, cardiac muscle 1
AIM1 absent in melanoma 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARL4A ADP-ribosylation factor-like 4A
AXIN1 axin 1
CD8A CD8a molecule
COLEC12 collectin sub-family member 12
CPVL carboxypeptidase, vitellogenic-like
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CSRP2 cysteine and glycine-rich protein 2
CST7 cystatin F (leukocystatin)
CTGF connective tissue growth factor
CTSG cathepsin G
CTSW cathepsin W
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
EGR1 early growth response 1
F13A1 coagulation factor XIII, A1 polypeptide
FAM69A family with sequence similarity 69, member A
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GLIPR1 GLI pathogenesis-related 1
GOLGA8A golgin A8 family, member A
H3F3B H3 histone, family 3B (H3.3B)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
IFI30 interferon, gamma-inducible protein 30
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KIAA0226L KIAA0226-like
KIF20A kinesin family member 20A
KRT18 keratin 18, type I
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MTA1 metastasis associated 1
NMU neuromedin U
NNMT nicotinamide N-methyltransferase
PALLD palladin, cytoskeletal associated protein
PCCA propionyl CoA carboxylase, alpha polypeptide
PCDH9 protocadherin 9
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDCD2 programmed cell death 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLCL2 phospholipase C-like 2
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRR7 proline rich 7 (synaptic)
RBM25 RNA binding motif protein 25
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SNX1 sorting nexin 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
TARP TCR gamma alternate reading frame protein
TCL1A T-cell leukemia/lymphoma 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TRAC T cell receptor alpha constant
TUBB2A tubulin, beta 2A class IIa
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
AHNAK2 AHNAK nucleoprotein 2
AHR aryl hydrocarbon receptor
AKR1C3 aldo-keto reductase family 1, member C3
ARMCX3 armadillo repeat containing, X-linked 3
ASCL1 achaete-scute family bHLH transcription factor 1
ASPN asporin
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BACE2 beta-site APP-cleaving enzyme 2
BTG3 BTG family, member 3
C3 complement component 3
C8ORF4 chromosome 8 open reading frame 4
CADM1 cell adhesion molecule 1
CCDC86 coiled-coil domain containing 86
CCNE2 cyclin E2
CCNF cyclin F
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CPE carboxypeptidase E
CPNE3 copine III
CTSK cathepsin K
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DEPTOR DEP domain containing MTOR-interacting protein
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EPS8 epidermal growth factor receptor pathway substrate 8
FGG fibrinogen gamma chain
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FMO5 flavin containing monooxygenase 5
GEM GTP binding protein overexpressed in skeletal muscle
GINS1 GINS complex subunit 1 (Psf1 homolog)
GNPDA1 glucosamine-6-phosphate deaminase 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
HES1 hes family bHLH transcription factor 1
HLF hepatic leukemia factor
HPGDS hematopoietic prostaglandin D synthase
HSPA1A heat shock 70kDa protein 1A
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGF1R insulin-like growth factor 1 receptor
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MBP myelin basic protein
MN1 meningioma (disrupted in balanced translocation) 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NCAM1 neural cell adhesion molecule 1
NEBL nebulette
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NET1 neuroepithelial cell transforming 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NR1H2 nuclear receptor subfamily 1, group H, member 2
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
NXN nucleoredoxin
OLFML2A olfactomedin-like 2A
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PBX1 pre-B-cell leukemia homeobox 1
PDGFRL platelet-derived growth factor receptor-like
PPIF peptidylprolyl isomerase F
RET ret proto-oncogene
RNASE4 ribonuclease, RNase A family, 4
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SHB Src homology 2 domain containing adaptor protein B
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SOX9 SRY (sex determining region Y)-box 9
SRSF1 serine/arginine-rich splicing factor 1
SSPN sarcospan
SST somatostatin
STAT1 signal transducer and activator of transcription 1, 91kDa
TFPI2 tissue factor pathway inhibitor 2
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TXNDC9 thioredoxin domain containing 9
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCAM1 vascular cell adhesion molecule 1
VIM vimentin
XBP1 X-box binding protein 1
YME1L1 YME1-like 1 ATPase
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZWINT ZW10 interacting kinetochore protein