BRD-K33379087_tivantinib_HT29_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-K33379087_tivantinib_HT29_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADIRF adipogenesis regulatory factor
AHI1 Abelson helper integration site 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANPEP alanyl (membrane) aminopeptidase
APOD apolipoprotein D
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC109B coiled-coil domain containing 109B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CP ceruloplasmin (ferroxidase)
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR24 24-dehydrocholesterol reductase
DLC1 DLC1 Rho GTPase activating protein
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
FAM46A family with sequence similarity 46, member A
FOSL1 FOS-like antigen 1
FST follistatin
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HP haptoglobin
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
INPP5F inositol polyphosphate-5-phosphatase F
IRS1 insulin receptor substrate 1
KCNK1 potassium channel, two pore domain subfamily K, member 1
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KRT18 keratin 18, type I
KYNU kynureninase
LTF lactotransferrin
MPP1 membrane protein, palmitoylated 1, 55kDa
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1M metallothionein 1M
NELL2 NEL-like 2 (chicken)
NTS neurotensin
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDZD8 PDZ domain containing 8
PODXL podocalyxin-like
RAB31 RAB31, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100A12 S100 calcium binding protein A12
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SNX10 sorting nexin 10
SYNJ2 synaptojanin 2
TPBG trophoblast glycoprotein
TRIB2 tribbles pseudokinase 2
UROD uroporphyrinogen decarboxylase
USP22 ubiquitin specific peptidase 22
VDAC1 voltage-dependent anion channel 1
VSNL1 visinin-like 1

decreased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CD24 CD24 molecule
CDK1 cyclin-dependent kinase 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CRABP1 cellular retinoic acid binding protein 1
CRIP1 cysteine-rich protein 1 (intestinal)
CTSZ cathepsin Z
CXCL10 chemokine (C-X-C motif) ligand 10
DCN decorin
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
DUSP6 dual specificity phosphatase 6
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
F12 coagulation factor XII (Hageman factor)
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GNAS GNAS complex locus
GPX3 glutathione peroxidase 3
HBB hemoglobin, beta
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
IFI44L interferon-induced protein 44-like
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ISG20 interferon stimulated exonuclease gene 20kDa
KIAA0101 KIAA0101
KRT19 keratin 19, type I
MELK maternal embryonic leucine zipper kinase
MSH6 mutS homolog 6
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MXI1 MAX interactor 1, dimerization protein
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUSAP1 nucleolar and spindle associated protein 1
PEG10 paternally expressed 10
PRKCD protein kinase C, delta
PSPH phosphoserine phosphatase
RAB2A RAB2A, member RAS oncogene family
RGS2 regulator of G-protein signaling 2
RNMT RNA (guanine-7-) methyltransferase
RRM2 ribonucleotide reductase M2
SH3YL1 SH3 and SYLF domain containing 1
SOX4 SRY (sex determining region Y)-box 4
TM4SF1 transmembrane 4 L six family member 1
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TNS3 tensin 3
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TPD52 tumor protein D52
TRIB1 tribbles pseudokinase 1
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCAM1 vascular cell adhesion molecule 1
VIM vimentin
WEE1 WEE1 G2 checkpoint kinase
XIST X inactive specific transcript (non-protein coding)