BRD-K33379087_tivantinib_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-K33379087_tivantinib_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BMI1 BMI1 proto-oncogene, polycomb ring finger
CAB39 calcium binding protein 39
CCND2 cyclin D2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CREM cAMP responsive element modulator
CXCL8 chemokine (C-X-C motif) ligand 8
DACH1 dachshund family transcription factor 1
DUSP22 dual specificity phosphatase 22
DUSP6 dual specificity phosphatase 6
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAR2 fatty acyl CoA reductase 2
FOSL1 FOS-like antigen 1
GDF15 growth differentiation factor 15
H2BFS H2B histone family, member S (pseudogene)
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HPCAL1 hippocalcin-like 1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
MEF2C myocyte enhancer factor 2C
MELK maternal embryonic leucine zipper kinase
MT1M metallothionein 1M
MTSS1 metastasis suppressor 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PHLDA1 pleckstrin homology-like domain, family A, member 1
PRSS2 protease, serine, 2 (trypsin 2)
PTX3 pentraxin 3, long
RGS2 regulator of G-protein signaling 2
SCD5 stearoyl-CoA desaturase 5
SLC16A6 solute carrier family 16, member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
SYNJ2 synaptojanin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
AHNAK2 AHNAK nucleoprotein 2
AK4 adenylate kinase 4
BCHE butyrylcholinesterase
BGN biglycan
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CADM1 cell adhesion molecule 1
CALD1 caldesmon 1
CAV2 caveolin 2
CCDC92 coiled-coil domain containing 92
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CLIC3 chloride intracellular channel 3
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL1A2 collagen, type I, alpha 2
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
CTSB cathepsin B
CXCL10 chemokine (C-X-C motif) ligand 10
DEFB1 defensin, beta 1
EDN1 endothelin 1
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
EPHA3 EPH receptor A3
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGFBP1 fibroblast growth factor binding protein 1
FLNA filamin A, alpha
FN1 fibronectin 1
FZD6 frizzled class receptor 6
GBP1 guanylate binding protein 1, interferon-inducible
GPNMB glycoprotein (transmembrane) nmb
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA2 heat shock 70kDa protein 2
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
KLF10 Kruppel-like factor 10
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LST1 leukocyte specific transcript 1
LYZ lysozyme
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAOA monoamine oxidase A
MGP matrix Gla protein
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MSMO1 methylsterol monooxygenase 1
MXRA5 matrix-remodelling associated 5
MYH10 myosin, heavy chain 10, non-muscle
NR1H2 nuclear receptor subfamily 1, group H, member 2
NREP neuronal regeneration related protein
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCP4 Purkinje cell protein 4
PDLIM4 PDZ and LIM domain 4
PDZK1IP1 PDZK1 interacting protein 1
PGM1 phosphoglucomutase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRKCI protein kinase C, iota
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SMAD1 SMAD family member 1
SPON2 spondin 2, extracellular matrix protein
SQLE squalene epoxidase
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN2 transgelin 2
TARBP1 TAR (HIV-1) RNA binding protein 1
TES testin LIM domain protein
THY1 Thy-1 cell surface antigen
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNS1 tensin 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TXNIP thioredoxin interacting protein
UBE2A ubiquitin-conjugating enzyme E2A
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WFDC2 WAP four-disulfide core domain 2