BRD-K33379087_tivantinib_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

174 genes differentially expressed following the BRD-K33379087_tivantinib_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADRB2 adrenoceptor beta 2, surface
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BTG2 BTG family, member 2
CCND2 cyclin D2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHIC2 cysteine-rich hydrophobic domain 2
CNOT4 CCR4-NOT transcription complex, subunit 4
COBL cordon-bleu WH2 repeat protein
COPS7A COP9 signalosome subunit 7A
CXCL13 chemokine (C-X-C motif) ligand 13
CYR61 cysteine-rich, angiogenic inducer, 61
DACH1 dachshund family transcription factor 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DUSP14 dual specificity phosphatase 14
DUSP5 dual specificity phosphatase 5
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ELANE elastase, neutrophil expressed
ESR1 estrogen receptor 1
FAM46A family with sequence similarity 46, member A
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXD1 forkhead box D1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BI histone cluster 1, H2bi
HIST1H2BK histone cluster 1, H2bk
HIST1H4H histone cluster 1, H4h
HMOX1 heme oxygenase 1
IER3 immediate early response 3
IER5 immediate early response 5
JUN jun proto-oncogene
KLF10 Kruppel-like factor 10
LGALS3 lectin, galactoside-binding, soluble, 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEB2 melanoma antigen family B2
MCL1 myeloid cell leukemia 1
MIR22HG MIR22 host gene
MMP9 matrix metallopeptidase 9
MT1E metallothionein 1E
MT1M metallothionein 1M
MT1X metallothionein 1X
MTSS1 metastasis suppressor 1
NCAM1 neural cell adhesion molecule 1
NFE2L2 nuclear factor, erythroid 2-like 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPR1 nuclear protein, transcriptional regulator, 1
PDGFC platelet derived growth factor C
PDLIM1 PDZ and LIM domain 1
PEG3 paternally expressed 3
PER2 period circadian clock 2
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PROM1 prominin 1
PTN pleiotrophin
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAP2B RAP2B, member of RAS oncogene family
RPS11 ribosomal protein S11
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SATB2 SATB homeobox 2
SESN1 sestrin 1
SFRP4 secreted frizzled-related protein 4
SIK3 SIK family kinase 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SSX1 synovial sarcoma, X breakpoint 1
STAR steroidogenic acute regulatory protein
TCF4 transcription factor 4
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM110 transmembrane protein 110
TMEM158 transmembrane protein 158 (gene/pseudogene)
VAMP8 vesicle-associated membrane protein 8
VDAC1 voltage-dependent anion channel 1
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZCCHC2 zinc finger, CCHC domain containing 2
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADD3 adducin 3 (gamma)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASPH aspartate beta-hydroxylase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BASP1 brain abundant, membrane attached signal protein 1
BIN1 bridging integrator 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CAV1 caveolin 1, caveolae protein, 22kDa
CCND1 cyclin D1
CD59 CD59 molecule, complement regulatory protein
CDK1 cyclin-dependent kinase 1
CEMIP cell migration inducing protein, hyaluronan binding
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A3 collagen, type VI, alpha 3
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL5 chemokine (C-X-C motif) ligand 5
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
ERBB3 erb-b2 receptor tyrosine kinase 3
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FSTL1 follistatin-like 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
HLA-B major histocompatibility complex, class I, B
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HMGA2 high mobility group AT-hook 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFNGR1 interferon gamma receptor 1
IFRD2 interferon-related developmental regulator 2
IGFBP4 insulin-like growth factor binding protein 4
KIAA0101 KIAA0101
KIF11 kinesin family member 11
L1CAM L1 cell adhesion molecule
LPAR1 lysophosphatidic acid receptor 1
LTB lymphotoxin beta (TNF superfamily, member 3)
MAP2K6 mitogen-activated protein kinase kinase 6
MARCKSL1 MARCKS-like 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NME4 NME/NM23 nucleoside diphosphate kinase 4
NUSAP1 nucleolar and spindle associated protein 1
PBK PDZ binding kinase
PGM1 phosphoglucomutase 1
PLP1 proteolipid protein 1
PNMA2 paraneoplastic Ma antigen 2
QDPR quinoid dihydropteridine reductase
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RGS5 regulator of G-protein signaling 5
S100A7 S100 calcium binding protein A7
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SOX11 SRY (sex determining region Y)-box 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TBC1D16 TBC1 domain family, member 16
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI2 tissue factor pathway inhibitor 2
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN6 tetraspanin 6
TUBB2B tubulin, beta 2B class IIb
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WNT5A wingless-type MMTV integration site family, member 5A
WWTR1 WW domain containing transcription regulator 1
ZNF395 zinc finger protein 395
ZNF589 zinc finger protein 589