BRD-K33272502_DG-041_VCAP_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

227 genes differentially expressed following the BRD-K33272502_DG-041_VCAP_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACKR3 atypical chemokine receptor 3
ACOX2 acyl-CoA oxidase 2, branched chain
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADM adrenomedullin
AGTR1 angiotensin II receptor, type 1
AHNAK AHNAK nucleoprotein
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALB albumin
ALCAM activated leukocyte cell adhesion molecule
ANXA1 annexin A1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BASP1 brain abundant, membrane attached signal protein 1
BIK BCL2-interacting killer (apoptosis-inducing)
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF48 chromosome 6 open reading frame 48
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCPG1 cell cycle progression 1
CDK14 cyclin-dependent kinase 14
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHRDL1 chordin-like 1
CLIC4 chloride intracellular channel 4
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COG5 component of oligomeric golgi complex 5
CRABP2 cellular retinoic acid binding protein 2
CSTA cystatin A (stefin A)
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSP desmoplakin
DST dystonin
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPRS glutamyl-prolyl-tRNA synthetase
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FAM13A family with sequence similarity 13, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGF13 fibroblast growth factor 13
FHL1 four and a half LIM domains 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GHR growth hormone receptor
GRB10 growth factor receptor-bound protein 10
GTPBP2 GTP binding protein 2
GUSBP3 glucuronidase, beta pseudogene 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
IARS isoleucyl-tRNA synthetase
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFRD1 interferon-related developmental regulator 1
IGFBP3 insulin-like growth factor binding protein 3
INHBB inhibin, beta B
INHBE inhibin, beta E
INSIG1 insulin induced gene 1
INSIG2 insulin induced gene 2
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
JCHAIN joining chain of multimeric IgA and IgM
KLF4 Kruppel-like factor 4 (gut)
KRT14 keratin 14, type I
KRT7 keratin 7, type II
KRT81 keratin 81, type II
LDLR low density lipoprotein receptor
LGMN legumain
LINC00341 long intergenic non-protein coding RNA 341
LOX lysyl oxidase
LRRC8D leucine rich repeat containing 8 family, member D
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP1B microtubule-associated protein 1B
MARCKS myristoylated alanine-rich protein kinase C substrate
MARS methionyl-tRNA synthetase
MBNL2 muscleblind-like splicing regulator 2
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MXI1 MAX interactor 1, dimerization protein
MYO1B myosin IB
NCK2 NCK adaptor protein 2
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NRN1 neuritin 1
NUPR1 nuclear protein, transcriptional regulator, 1
OXTR oxytocin receptor
PDGFA platelet-derived growth factor alpha polypeptide
PHGDH phosphoglycerate dehydrogenase
PLSCR3 phospholipid scramblase 3
PPAP2A phosphatidic acid phosphatase type 2A
PSAT1 phosphoserine aminotransferase 1
PTN pleiotrophin
R3HDM2 R3H domain containing 2
RHOQ ras homolog family member Q
RTN4 reticulon 4
SARS seryl-tRNA synthetase
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPP1 selenoprotein P, plasma, 1
SGCE sarcoglycan, epsilon
SH3YL1 SH3 and SYLF domain containing 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SKAP2 src kinase associated phosphoprotein 2
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SORBS2 sorbin and SH3 domain containing 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRPX sushi-repeat containing protein, X-linked
STC2 stanniocalcin 2
TARS threonyl-tRNA synthetase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TSPAN7 tetraspanin 7
USP25 ubiquitin specific peptidase 25
VCAN versican
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ASF1B anti-silencing function 1B histone chaperone
ASRGL1 asparaginase like 1
ATAD2 ATPase family, AAA domain containing 2
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BRCA1 breast cancer 1, early onset
BZW2 basic leucine zipper and W2 domains 2
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNE2 cyclin E2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA4 cell division cycle associated 4
CENPU centromere protein U
CHEK2 checkpoint kinase 2
CLU clusterin
CYBA cytochrome b-245, alpha polypeptide
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EXO1 exonuclease 1
FANCG Fanconi anemia, complementation group G
FASTKD5 FAST kinase domains 5
FEN1 flap structure-specific endonuclease 1
FUS FUS RNA binding protein
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GMPR guanosine monophosphate reductase
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
H2BFS H2B histone family, member S (pseudogene)
HELLS helicase, lymphoid-specific
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H2BK histone cluster 1, H2bk
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HNRNPM heterogeneous nuclear ribonucleoprotein M
JADE2 jade family PHD finger 2
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LOC100505650 uncharacterized LOC100505650
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MRPL20 mitochondrial ribosomal protein L20
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NASP nuclear autoantigenic sperm protein (histone-binding)
NOP56 NOP56 ribonucleoprotein
ORC6 origin recognition complex, subunit 6
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
RFC2 replication factor C (activator 1) 2, 40kDa
RNASEH2A ribonuclease H2, subunit A
RRM2 ribonucleotide reductase M2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SDF2L1 stromal cell-derived factor 2-like 1
SFN stratifin
SHCBP1 SHC SH2-domain binding protein 1
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SOD2 superoxide dismutase 2, mitochondrial
SPC25 SPC25, NDC80 kinetochore complex component
SRSF2 serine/arginine-rich splicing factor 2
STMN1 stathmin 1
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TFPI2 tissue factor pathway inhibitor 2
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TRA2B transformer 2 beta homolog (Drosophila)
TRIP13 thyroid hormone receptor interactor 13
TUBB4B tubulin, beta 4B class IVb
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein